ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2017-4-7-15ssmu-1020Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESОрексинергическая система мозга и патогенетические основы нарушений цикла «сон – бодрствование» при нарколепсииOrexin system and pathogenesis of sleep-wake cycle disturbances in narcolepsyГавриловЮ. В.GavrilovYu. V.

канд. мед. наук, ст. науч. сотрудник

отдел общей патологии и патологической физиологии

197376, г. Санкт-Петербург, ул. Академика Павлова, 12 

PhD, Senior Researcher, Department of General Pathology and Pathological Physiology

12, Academician Pavlova Str., St.-Petersburg, 197376

yury_doctor@mail.ruДеревцоваК. З.DerevtsovaK. Z.

канд. биол. наук, ст. науч. сотрудник

отдел общей патологии и патологической физиологии

197376, г. Санкт-Петербург, ул. Академика Павлова, 12 

PhD, Senior Researcher, Department of General Pathology and Pathological Physiology

12, Academician Pavlova Str., St.-Petersburg, 197376

КорневаЕ. А.KornevaH. A.

академик РАН, д-р мед. наук, гл. науч. сотрудник

отдел общей патологии и патологической физиологии

197376, г. Санкт-Петербург, ул. Академика Павлова, 12 

профессор

кафедра патофизиологии

199034, г. Санкт-Петербург, Университетская наб., 7–9 

Academician of the Russian Academy Sciences, DM, Chief Senior Researcher, Department of General Pathology and Pathological Physiology

12, Academician Pavlova Str., St.-Petersburg, 197376

Professor of Pathophysiology Department

7–9, Universitetskay Nab., St.-Petersburg, 199034

Институт экспериментальной медицины (ИЭМ)РоссияInstitute of Experimental Medicine (IEM)Russian FederationИнститут экспериментальной медицины (ИЭМ); Санкт-Петербургский государственный университетРоссияInstitute of Experimental Medicine (IEM); St.-Petersburg State UniversityRussian Federation201702012018164715Copyright © Гаврилов Ю.В., Деревцова К.З., Корнева Е.А., 20182018Гаврилов Ю.В., Деревцова К.З., Корнева Е.А.Gavrilov Y.V., Derevtsova K.Z., Korneva H.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/1020

Сон является одной из важнейших витальных функций, и изучение основных механизмов, в результате которых нарушается регуляция цикла «сон – бодрствование», выступает одной из приоритетных задач современной медицинской науки. Известно, что система орексин-содержащих нейронов гипоталамуса, сигналы от которых поступают во все центры бодрствования, играет ведущую роль в инициации и поддержании этого состояния. Недостаточность функции орексинергической системы гипоталамуса приводит к нарушениям цикла «сон – бодрствование» и развитию тяжелых заболеваний – нарколепсии и катаплексии. Представленный обзор посвящен рассмотрению возможных механизмов развития патологических изменений функций орексин-содержащих нейронов гипоталамуса и заболеваний, обусловленных ими. 

Sleep is the one of the most important vital functions of the body. The study of the primary mechanisms that result in disturbance of the sleep-wake cycle is a priority of modern medical science. It is known that the orexin neurons of the hypothalamus, which send projections to all waking centers, play a leading role in initiating and maintaining this state. Insufficiency of the function of the orexinergic system of the hypothalamus leads to disturbances in the sleep-wake cycle and the development of the severe diseases of narcolepsy and cataplexy. The presented review is devoted to the investigation of possible mechanisms of development of pathological changes in the orexin-containing neurons functions and the diseases caused by them. 

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The authors declare that there are no conflicts of interest present.