ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2017-4-42-60ssmu-1023Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESРегуляция объема клеток эпителия в норме и при патологииThe regulation of epithelial cells volume in norm and pathologyПономарчукО. О.PonomarchukO. O.

биологический факультет

119991, г. Москва, Ленинские Горы, 1/12

научно-исследовательский центр 

H2X 0A9, г. Монреаль, ул. Сент-Дени, 900 

Faculty of Biology

1/12, Leninskie Gory, 119991, Moscow

900, Tour Viger, rue St-Denis, Montreal, Quebec, H2X 0A9

МаксимовГ. В.МаximovG. V.

биологический факультет

119991, г. Москва, Ленинские Горы, 1/12

Faculty of Biology

1/12, Leninskie Gory, 119991, Moscow

ОрловС. Н.ОrlovS. N.

д-р мед. наук, профессор, биологический факультет

119991, г. Москва, Ленинские Горы, 1/12

DM, Professor, Faculty of Biology

1/12, Leninskie Gory, 119991, Moscow

sergeiorlov@yandex.ruМосковский государственный университет имени М.В. Ломоносова; Научно-исследовательский центр Монреальского университетаРоссияM.V. Lomonosov Moscow State University; Centre de Recherche, Centre Hospitalier de l’Université de Montréal (CRCHUM)Russian FederationМосковский государственный университет имени М.В. ЛомоносоваРоссияM.V. Lomonosov Moscow State UniversityRussian Federation2017020120181644260Copyright © Пономарчук О.О., Максимов Г.В., Орлов С.Н., 20182018Пономарчук О.О., Максимов Г.В., Орлов С.Н.Ponomarchuk O.O., Маximov G.V., Оrlov S.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/1023

Способность регулировать объем в ответ на изменения внутриклеточной и внеклеточной осмолярности среды является одной из фундаментальных функций клеток. Изменения клеточного объема приводят к запуску множества внутриклеточных сигнальных каскадов, активирующих защитные и адаптивные механизмы. Как правило, регулирование объема происходит за счет транспорта осмолитов, результатом которого является восстановление объема внутриклеточной воды и нормализация клеточных функций. В данном обзоре показано физиологическое значение процессов регуляторного уменьшения объема и регуляторного увеличения объема в ответ на флуктуации вне- и внутриклеточной осмолярности на примере эпителиальных клеток. 

The ability to regulate volume in response to changes in intracellular and extracellular osmolarity is one of the fundamental cell functions. Cell volume changes stimulate a variety of intracellular signaling cascades that activate protective and adaptive mechanisms. In general, the regulation of volume occurs due to the transport of osmolytes, which results in the restoration of the intracellular water volume and the normalization of cellular functions. In this review we focused on the physiological significance of regulatory volume decrease (RVD) and regulatory volume increase (RVI) in response to fluctuations of extra- and intracellular osmolarity in the context of epithelial cells. 

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The authors declare that there are no conflicts of interest present.