ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2017-4-86-93ssmu-1026Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESВоздействие на митогенактивируемые протеинкиназы как новое направление регуляции роста соединительной тканиInfluence on mitogen-activated protein kinases as a new direction of connective tissue growth regulationШурыгинаИ. А.ShuryginaI. A.

д-р мед. наук, профессор РАН, зам. директора по научной работе

664003, г. Иркутск, ул. Борцов Революции, 1 

DM, Professor, Deputy Director for Research

1, Bortsov Revolutsii Str., Irkutsk, 664003

irinashurygina@gmail.comШурыгинМ. Г.ShuryginM. G.

д-р мед наук, зав. отделом

научно-лабораторный отдел

664003, г. Иркутск, ул. Борцов Революции, 1 

DM, Head of Scientific and Laboratory Department

1, Bortsov Revolutsii Str., Irkutsk, 664003

ЗеленинВ. Н.ZeleninN. V.

пластический врач-хирург

664003, г. Иркутск, ул. Борцов Революции, 1 

Surgeon

1, Bortsov Revolutsii Str., Irkutsk, 664003

АюшиноваН. И.AyushinovaN. I.

врач-хирург высшей квалификационной категории

отделение гнойной хирургии № 1

664003, г. Иркутск, ул. Борцов Революции, 1 

Surgeon, Department of Purulent Surgery No. 1

1, Bortsov Revolutsii Str., Irkutsk, 664003

Иркутский научный центр хирургии и травматологии (ИНЦХТ)РоссияIrkutsk Scientific Center of Surgery and Traumatology (ISCST)Russian Federation2017020120181648693Copyright © Шурыгина И.А., Шурыгин М.Г., Зеленин В.Н., Аюшинова Н.И., 20182018Шурыгина И.А., Шурыгин М.Г., Зеленин В.Н., Аюшинова Н.И.Shurygina I.A., Shurygin M.G., Zelenin N.V., Ayushinova N.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/1026

В обзоре представлена современная классификация, функции основных групп митогенактивируемых протеинкиназ (МАРК). Приведены данные о путях их активации и функционирования. Основное внимание уделено семейству р38 МАРК. В обзоре воздействие на данные сигнальные каскады рассмотрено как перспективное направление воздействия на рост соединительной ткани. В этом аспекте обобщен мировой опыт по активации и блокаде внутриклеточных каскадов. Обобщен собственный опыт работы в данном направлении. В частности продемонстрировано, что стимуляция р38 МАРК при подавлении активности JNK каскада ведет к ускоренному образованию соединительной ткани в зоне послеоперационного хирургического рубца, доказана возможность управления ростом соединительной ткани при воздействии на МАР-киназные каскады. Пролонгированная блокада р38 МАРК снижает ширину кожного рубца и плотность коллагеновых волокон в зоне формирования послеоперационного рубца, снижает интенсивность спайкообразования в брюшной полости при травме брюшины.

Таким образом, учитывая важную роль и универсальность МАР-киназных механизмов регуляции клеточного роста и дифференцировки, перспективно изучение участия данных механизмов в универсаль- ных биологических процессах, таких как воспаление, апоптоз, регенерация, а также разработка на этой основе способов управления течением этих процессов. Использование стимуляторов и блокаторов МАР-киназных механизмов перспективно как новое направление в лечении многих заболеваний, патогенез которых связан с нарушением клеточной дифференцировки, пролиферации, избыточной выработки цитокинов, управлением ростом соединительной ткани. 

This review presents current classification, functions of main groups of mitogen-activated protein kinases (MAPK) and summarizes data on the ways of their activation and functioning, giving particular emphasis to p38 MAPK. The authors consider the influence on these signaling cascades as a promising direction for activation of connective tissue growth. This article summarizes international practices on the activation and blocking of intracellular cascades and also the authors’ own experience in this field. In particular, the article shows that p38 MAP-kinase stimulation while JNK inactivation causes accelerated formation of connective tissue in the area of postoperative surgical scar. The authors prove the opportunity to manage connective tissue growth influencing MAPK cascades – prolonged blockade of p38 МАРК reduces scar width and collagen fiber density in the area of postoperative scars and decreases intensity of adhesions in the abdominal cavity in abdominal trauma.

Therefore, considering the importance and flexibility of MAP-kinase mechanisms of cell growth regulation and differentiation, studying the use of these mechanisms in biological processes (such as inflammation, apoptosis, regeneration) and the development the methods of management of these processes show promise. Using stimulators and inhibitors of MAP-kinase mechanisms is a promising new direction in treatment of the diseases with pathogeny related to the disorder of cellular differentiation, proliferation, excessive cytokine production and regulation of connective tissue growth.

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The authors declare that there are no conflicts of interest present.