ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2018-1-130-138ssmu-1123Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL PAPERSВремя реакции в ответ на эмоциональные стимулы (включая фотопортреты с различной мимикой) в ходе фМРТ-исследования лиц с легкой и умеренной депрессией, дистимиейThe response time to emotional stimuli (including facial expressions photos) during the fMRI scanning in affective disorders: mild and moderate depression and dysthymic disorderМельниковМ. Е.Mel’nikovM. Ye.

Мельников Михаил Евгеньевич, канд. биол. наук, ст. науч. сотрудник.

 

Mel’nikov Mikhail Ye., PhD, Senior Researcher.

2/12, Timakova Str., Novosibirsk, 630117; 2, Pirogova Str., Novosibirsk, 630090.

mikhail-melnikov@mail.ruБезматерныхД. Д.BezmaternykhD. D.

Безматерных Дмитрий Дмитриевич, лаборант-исследователь;  магистрант.

 

Bezmaternykh Dmitriy D., Аssistant; Student.

2/12, Timakova Str., Novosibirsk, 630117; 2, Pirogova Str., Novosibirsk, 630090.

ПетровскийЕ. Д.PetrovskiyE. D.

Петровский Евгений Дмитриевич, лаборант-исследователь.

 

Petrovskiy Evgeniy D., Аssistant.

3a, Institutskaya Str., Novosibirsk, 630090.

КозловаЛ. И.KozlovaL. I.

Козлова Людмила Игоревна, мл. науч. сотрудник; науч. сотрудник.

Kozlova L’udmila I., Junior Researcher; Researcher.

2/12, Timakova Str., Novosibirsk, 630117; 2, Pirogova Str., Novosibirsk, 630090.

ШтаркМ. Б.ShtarkM. B.

Штарк Марк Борисович, д-р биол. наук, профессор, академик РАН, руководитель отдела;  зав. лабораторией.

 

Shtark Mark B., DM, Professor, Аcademician of RAS, Head of the Divivsion; Head of the Laboratory.

2/12, Timakova Str., Novosibirsk, 630117; 2, Pirogova Str., Novosibirsk, 630090.

СавеловА. А.SavelovA. A.

Савелов Александр Александрович, канд. физ.-мат. наук, лаборант-исследователь.

 

Savelov Alexandr A., PhD, Senior Researcher. 

3a, Institutskaya Str., Novosibirsk, 630090

ШубинаО. С.ShubinaO. S.

Шубина Ольга Сергеевна, канд. мед. наук, вед. науч. сотрудник.

 

Shubina Ol’ga S., PhD, Leading Researcher.

2/12, Timakova Str., Novosibirsk, 630117.

НатароваК. А.NatarovaK. A.

Натарова Кира Александровна, канд. мед. наук, ст. психотерапевт.

630007, г. Новосибирск, ул. Серебренниковская, 2.

Natarova Kira Alexandrovna, PhD, Senior Psychotherapis.

2, Serebrennikovskaya Str., Novosibirsk, 630007.

Научно-исследовательский институт молекулярной биологии и биофизики (НИИ МББ); Национальный исследовательский Новосибирский государственный университет (НИ НГУ).РоссияResearch Institute of Molecular Biology and Biophysics (RIMBB) ; National Research Novosibirsk State University (NR NSU).Russian FederationМеждународный томографический центр (МТЦ) Сибирского отделения (СО) Российской академии наук (РАН).РоссияInternational Tomography Center (ITC), Siberian Branch of the Russian Academy of Sciences (SB RAS).Russian FederationНаучно-исследовательский институт молекулярной биологии и биофизики (НИИ МББ) .РоссияResearch Institute of Molecular Biology and Biophysics (RIMBB) .Russian FederationМеждународный институт психологии и психотерапии (МИПП).РоссияInternational Institute of Psychology and Psychotherapy (IIPP).Russian Federation201830032018171130138Copyright © Мельников М.Е., Безматерных Д.Д., Петровский Е.Д., Козлова Л.И., Штарк М.Б., Савелов А.А., Шубина О.С., Натарова К.А., 20182018Мельников М.Е., Безматерных Д.Д., Петровский Е.Д., Козлова Л.И., Штарк М.Б., Савелов А.А., Шубина О.С., Натарова К.А.Mel’nikov M.Y., Bezmaternykh D.D., Petrovskiy E.D., Kozlova L.I., Shtark M.B., Savelov A.A., Shubina O.S., Natarova K.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/1123

Цель исследования – оценить время и содержание реакций на эмоциональные стимулы в процессе фМРТ-исследования у лиц с легким или умеренным депрессивным эпизодом или дистимией.

Материалы и методы

Материалы и методы. В исследовании приняли участие группа (21 человек) с диагностированным легким или умеренным депрессивным эпизодом или дистимией (Д) и контрольная группа (21 волонтер) (З), идентичных по полу и возрасту. В двух задачах испытуемые, находясь внутри магнитно-резонансного томографа, воспринимали изображения лиц с различной эмоциональной мимикой. В первой пробе от участников требовалось определить пол людей на портретах, во второй – переживаемые ими эмоции. В третьей задаче предъявлялись изображения, которые нужно было разделить на нравящиеся и не нравящиеся. Ответ давался нажатием одной из двух кнопок. Оценивались время реакции и содержание ответов.

Результаты

Результаты. По большинству рассчитанных параметров лица с депрессивным эпизодом не отличались от условно здоровых людей. Тем не менее в первой задаче эти испытуемые характеризовались более медленной реакцией на лица с нейтральной мимикой (З = (1 415 ± 408) мс, Д = (1 878 ± 850) мс; t = 2,25; p < 0,05) и выражением отвращения (З = (1 183 ± 310) мс, Д = (1 526 ± 646) мс; t = 2,20; p < 0,05) и большим стандартным отклонением времени реакции на черты отвращения (З = (219 ± 125) мс, Д = (675 ± 645) мс; t = 3,18; p < 0,01), радости (З = (445 ± 310) мс, Д = (836 ± 579) мс; t = 2,73; p < 0,05), удивления (З = (580 ± 438) мс, Д = (1 043 ± 785) мс; t = 2,36; p < 0,05), а также на нейтральные портреты (З = (487 ± 416) мс, Д = (895 ± 727) мс; t = 2,23; p < 0,05). Во второй задаче в группе лиц с депрессивным эпизодом большим было стандартное отклонение времени реакции для лиц с брезгливой мимикой (З = (1 506 ± 1 273) мс, Д = (2 168 ± 1 355) мс; U = 131; p < 0,05). Кроме того, эти участники несколько реже выбирали ответ «радость» для характеристики мимики лиц (З = (6,8 ± 1,1) мс, Д = (6,0 ± 0,8) мс; U = 131; p < 0,05).

Заключение

Заключение. Показаны достоверное замедление реакций лиц с легким и умеренным депрессивным эпизодом в контексте «фоновой» обработки эмоциональной экспрессии и их тенденция реже определять мимику как радостную при целенаправленном распознавании чувств других людей. Однако изучение роли этих особенностей в развитии депрессивных расстройств и как диагностических маркеров требует дальнейших исследований.

Objective

Objective. Estimation of the response time and accuracy of emotional stimuli during the fMRI task fulfillment in participants suffering from mild to moderate depressive disorder or from dysthymic disorder.

Materials and methods

Materials and methods. 21 subjects with mild to moderate depressive disorder or dysthymic disorder (D) participated, and 21 healthy volunteers (H) matched by age and sex ratio were included in the control group.  In two fMRI paradigms subjects were observing photos of the faces with different emotional expressions. The first task was to guess the gender of the people on the screen, and the second one was to recognize the emotion experienced by the person in the photo. In the third paradigm participants were sorting different images into pleasant and unpleasant. The subjects responded by pressing one of two buttons. The response time and accuracy were the subjects of analysis.

Results

Results. On the most of the computed parameters patients with depressive disorder did not differ from controls. However, in the first paradigm these subjects demonstrated slower reaction to neutral (H = (1415 ± 408) ms,  D = (1 878 ± 850) ms; t = 2.25; p < 0,05) and disgusted (H = (1 183 ± 310) ms, D = (1 526 ± 646) ms; t = 2.20; p < 0.05) expressions, and greater standard deviations of the response time to disgusted (H = (219 ± 125) ms,  D = (675 ± 645) ms; t = 3.18; p < 0,01), happy (H = (445 ± 310) ms, D = (836 ± 579) ms; t = 2.73;  p < 0.05), surprised (H = (580 ± 438) ms, D = (1 043 ± 785) ms; t = 2.36; p < 0,05), and neutral  (H = (487 ± 416) ms, D = (895 ± 727) ms; t = 2.23; p < 0.05) faces. On the second stage group of participants with depressive disorder had greater standard deviation of the response time to disgusted portraits (H = (1 506 ± 1 273) ms, D = (2 168 ± 1 355) ms; U =131; p < 0.05). Moreover, subjects diagnosed with a depressive disorder less often chose the answer “happy” (H = (6,8 ± 1,1) ms, D = (6.0 ± 0.8) ms; U = 131; p < 0.05) while guessing the emotion in the photo.

Conclusion

Conclusion. Participants diagnosed with mild to moderate depressive disorder or dysthymic disorder perform significantly slower than healthy ones during the “background” processing of the facial expressions and also tend to identify mimic as happy less often than controls while aiming to recognize the feelings of others. However, the role of these features in the progress of depressive disorders and their perspectives as diagnostic markers are subjects for further research.

депрессивный эпизодраспознавание эмоциональной мимикиэмоциональная валентность стимуловвремя реакцииэмоцииdepressive disorderdetection of the facial expressionsemotional valence of the stimulireaction timeemotionsReferencesGollan J.K., McCloskey M., Hoxha D., Coccaro E.F. How do depressed and healthy adults interpret nuanced facial expressions? Journal of Abnormal Psychology. 2010; 119 (4): 804–810. DOI: 10.1037/a0020234.Gollan J.K., McCloskey M., Hoxha D., Coccaro E.F. How do depressed and healthy adults interpret nuanced facial expressions? Journal of Abnormal Psychology. 2010; 119 (4): 804–810. DOI: 10.1037/a0020234.Biyik U. Keskin D., Oguz K. et al. Facial emotion recognition in remitted depressed women. Asian Journal of Psychiatry. 2015; 17: 111–113. DOI: 10.1016/j. ajp.2015.08.001.Biyik U. Keskin D., Oguz K. et al. Facial emotion recognition in remitted depressed women. Asian Journal of Psychiatry. 2015; 17: 111–113. DOI: 10.1016/j. ajp.2015.08.001.Peckham A.D., McHugh R.K., Otto M.W. A meta-analysis of the magnitude of biased attention in depression. Depression and Anxiety. 2010; 27 (12): 1135–1142. DOI: 10.1002/da.20755.Peckham A.D., McHugh R.K., Otto M.W. A meta-analysis of the magnitude of biased attention in depression. Depression and Anxiety. 2010; 27 (12): 1135–1142. DOI: 10.1002/da.20755.Maalouf F.T., Clark L., Tavitian L. et al. Bias to negative emotions: A depression state-dependent marker in adolescent major depressive disorder. Psychiatry Research. 2012; 198 (1): 28–33. DOI: 10.1016/j.psychres.2012.01.030.Maalouf F.T., Clark L., Tavitian L. et al. Bias to negative emotions: A depression state-dependent marker in adolescent major depressive disorder. Psychiatry Research. 2012; 198 (1): 28–33. DOI: 10.1016/j.psychres.2012.01.030.Fritzsche A., Dahme B., Gotlib I.H. et al. Specificity of cognitive biases in patients with current depression and remitted depression and in patients with asthma. Psychological Medicine. 2009; 40 (5): 815. DOI: 10.1017/s0033291709990948.Fritzsche A., Dahme B., Gotlib I.H. et al. Specificity of cognitive biases in patients with current depression and remitted depression and in patients with asthma. Psychological Medicine. 2009; 40 (5): 815. DOI: 10.1017/s0033291709990948.Milders Bell S., Platt J. et al. Stable expression recognition abnormalities in unipolar depression. Psychiatry Research. 2010; 179 (1): 38–42. DOI: 10.1016/j.psychres.2009.05.015.Milders Bell S., Platt J. et al. Stable expression recognition abnormalities in unipolar depression. Psychiatry Research. 2010; 179 (1): 38–42. DOI: 10.1016/j.psychres.2009.05.015.Cheng P., Preston S.D., Jonides J. et al. Evidence against mood-congruent attentional bias in Major Depressive Disorder. Psychiatry Research. 2015; 230 (2): 496–505. DOI: 10.1016/j.psychres.2015.09.043.Cheng P., Preston S.D., Jonides J. et al. Evidence against mood-congruent attentional bias in Major Depressive Disorder. Psychiatry Research. 2015; 230 (2): 496–505. DOI: 10.1016/j.psychres.2015.09.043.Markela-Lerenc J., Kaiser S., Gölz T. et al. Attentional Bias in Depressive Patients and the Moderating Effect of Concurrent Anxiety. Psychopathology. 2011; 44 (3): 193–200. DOI: 10.1159/000319370.Markela-Lerenc J., Kaiser S., Gölz T. et al. Attentional Bias in Depressive Patients and the Moderating Effect of Concurrent Anxiety. Psychopathology. 2011; 44 (3): 193–200. DOI: 10.1159/000319370.Arnone D., McKie S., Elliott R et al. Increased amygdala responses to sad but not fearful faces in major depression: relation to mood state and pharmacological treatment. American Journal of Psychiatry. 2012; 169 (8): 841–850. DOI: 10.1176/appi.ajp.2012.11121774.Arnone D., McKie S., Elliott R et al. Increased amygdala responses to sad but not fearful faces in major depression: relation to mood state and pharmacological treatment. American Journal of Psychiatry. 2012; 169 (8): 841–850. DOI: 10.1176/appi.ajp.2012.11121774.Bermpohl F., Walter M., Sajon В. et al. Attentional modulation of emotional stimulus processing in patients with major depression – alterations in prefrontal cortical regions. Neuroscience Letters. 2009; 463 (2): 108–113. DOI: 10.1016/j.neulet.2009.07.061.Bermpohl F., Walter M., Sajon В. et al. Attentional modulation of emotional stimulus processing in patients with major depression – alterations in prefrontal cortical regions. Neuroscience Letters. 2009; 463 (2): 108–113. DOI: 10.1016/j.neulet.2009.07.061.Demenescu L.R., Renken R., Kortekaas R. et al. Neural correlates of perception of emotional facial expressions in out-patients with mild-to-moderate depression and anxiety. A multicenter fMRI study. Psychological Medicine. 2011; 41 (11): 2253–2264. DOI: 10.1017/ S0033291711000596.Demenescu L.R., Renken R., Kortekaas R. et al. Neural correlates of perception of emotional facial expressions in out-patients with mild-to-moderate depression and anxiety. A multicenter fMRI study. Psychological Medicine. 2011; 41 (11): 2253–2264. DOI: 10.1017/ S0033291711000596.Greening S.G., Osuch E.A., Williamson P.C., Mitchell D.G. Emotion-related brain activity to conflicting socio-emotional cues in unmedicated depression. Journal of Affective Disorders. 2013; 150 (3): 1136–1141. DOI: 10.1016/j.jad.2013.05.053.Greening S.G., Osuch E.A., Williamson P.C., Mitchell D.G. Emotion-related brain activity to conflicting socio-emotional cues in unmedicated depression. Journal of Affective Disorders. 2013; 150 (3): 1136–1141. DOI: 10.1016/j.jad.2013.05.053.Grimm S., Boesiger P., Beck J. et al. Altered negative BOLD responses in the default-mode network during emotion processing in depressed subjects. Neuropsychopharmacology. 2009; 34 (4): 932–943. DOI: 10.1038/npp.2008.81.Grimm S., Boesiger P., Beck J. et al. Altered negative BOLD responses in the default-mode network during emotion processing in depressed subjects. Neuropsychopharmacology. 2009; 34 (4): 932–943. DOI: 10.1038/npp.2008.81.Miskowiak K.W., Glerup L., Vestbo C. et al. Different neural and cognitive response to emotional faces in healthy monozygotic twins at risk of depression. Psychological Medicine. 2015; 45 (7): 1447–1458. DOI: 10.1017/S0033291714002542.Miskowiak K.W., Glerup L., Vestbo C. et al. Different neural and cognitive response to emotional faces in healthy monozygotic twins at risk of depression. Psychological Medicine. 2015; 45 (7): 1447–1458. DOI: 10.1017/S0033291714002542.Smith R., Allen J.J., Thayer J.F., Lane R.D. Altered functional connectivity between medial prefrontal cortex and the inferior brainstem in major depression during appraisal of subjective emotional responses: A preliminary study. Biological Psychology. 2015; 108: 13–24. DOI: 10.1016/j.biopsycho.2015.03.007.Smith R., Allen J.J., Thayer J.F., Lane R.D. Altered functional connectivity between medial prefrontal cortex and the inferior brainstem in major depression during appraisal of subjective emotional responses: A preliminary study. Biological Psychology. 2015; 108: 13–24. DOI: 10.1016/j.biopsycho.2015.03.007.Surguladze S., Brammer M.J., Keedwell P. et al. A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder. Biological Psychiatry. 2005; 57 (3): 201–209. DOI: 10.1016/j. biopsych.2004.10.028.Surguladze S., Brammer M.J., Keedwell P. et al. A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder. Biological Psychiatry. 2005; 57 (3): 201–209. DOI: 10.1016/j. biopsych.2004.10.028.Degabriele R., Lagopoulos J. Delayed early face processing in bipolar disorder. NeuroReport. 2012; 23 (3): 152–156. DOI: 10.1097/wnr.0b013e32834f218c.Degabriele R., Lagopoulos J. Delayed early face processing in bipolar disorder. NeuroReport. 2012; 23 (3): 152–156. DOI: 10.1097/wnr.0b013e32834f218c.Siegle G.J., Granholm E., Ingram R.E., Matt G.E. Pupillary and reaction time measures of sustained processing of negative information in depression. Biological Psychiatry. 2001; 49 (7): 624–636. DOI: 10.1016/s00063223(00)01024-6.Siegle G.J., Granholm E., Ingram R.E., Matt G.E. Pupillary and reaction time measures of sustained processing of negative information in depression. Biological Psychiatry. 2001; 49 (7): 624–636. DOI: 10.1016/s00063223(00)01024-6.Isaac L., Vrijsen J.N., Rinck M. et al. Shorter gaze duration for happy faces in current but not remitted depression: Evidence from eye movements. Psychiatry Research. 2014; 218 (1–2): 79–86. DOI: 10.1016/j.psychres.2014.04.002.Isaac L., Vrijsen J.N., Rinck M. et al. Shorter gaze duration for happy faces in current but not remitted depression: Evidence from eye movements. Psychiatry Research. 2014; 218 (1–2): 79–86. DOI: 10.1016/j.psychres.2014.04.002.Leppänen J.M., Milders M., Bell J.S. et al. Depression biases the recognition of emotionally neutral faces. Psychiatry Research. 2004; 128 (2): 123–133. DOI: 10.1016/j. psychres.2004.05.020.Leppänen J.M., Milders M., Bell J.S. et al. Depression biases the recognition of emotionally neutral faces. Psychiatry Research. 2004; 128 (2): 123–133. DOI: 10.1016/j. psychres.2004.05.020.Maniglio R., Gusciglio F., Lofrese V. et al. Biased processing of neutral facial expressions is associated with depressive symptoms and suicide ideation in individuals at risk for major depression due to affective temperaments. Comprehensive Psychiatry. 2014; 55 (3): 518–525. DOI: 10.1016/j.comppsych.2013.10.008.Maniglio R., Gusciglio F., Lofrese V. et al. Biased processing of neutral facial expressions is associated with depressive symptoms and suicide ideation in individuals at risk for major depression due to affective temperaments. Comprehensive Psychiatry. 2014; 55 (3): 518–525. DOI: 10.1016/j.comppsych.2013.10.008.Gollan J.K., Pane H.T., McCloskey M.S., Coccaro E.F. Identifying differences in biased affective information processing in major depression. Psychiatry Research. 2008; 159 (1–2): 18–24. DOI: 10.1016/j.psychres.2007.06.011.Gollan J.K., Pane H.T., McCloskey M.S., Coccaro E.F. Identifying differences in biased affective information processing in major depression. Psychiatry Research. 2008; 159 (1–2): 18–24. DOI: 10.1016/j.psychres.2007.06.011.Bourke C., Douglas K., Porter R. Processing of facial emotion expression in major depression: a review. Australian and New Zealand Journal of Psychiatry. 2010; 44 (8): 681–696. DOI: 10.3109/00048674.2010.496359.Bourke C., Douglas K., Porter R. Processing of facial emotion expression in major depression: a review. Australian and New Zealand Journal of Psychiatry. 2010; 44 (8): 681–696. DOI: 10.3109/00048674.2010.496359.Surguladze S.A., Young A.W., Senior C. et al. Recognition Accuracy and Response Bias to Happy and Sad Facial Expressions in Patients With Major Depression. Neuropsychology. 2004; 18 (2): 212–218. DOI: 10.1037/08944105.18.2.212.Surguladze S.A., Young A.W., Senior C. et al. Recognition Accuracy and Response Bias to Happy and Sad Facial Expressions in Patients With Major Depression. Neuropsychology. 2004; 18 (2): 212–218. DOI: 10.1037/08944105.18.2.212.

The authors declare that there are no conflicts of interest present.