ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2018-1-232-238ssmu-1133Research ArticleСЛУЧАЙ ИЗ КЛИНИЧЕСКОЙ ПРАКТИКИCLINICAL CASESКлиническое наблюдение ВПЧ-позитивной опухоли молочной железыThe clinical observation of human papillomavirus positive breast tumorИбрагимоваМ. К.IbragimovaM. K.

Ибрагимова Марина Константиновна, мл. науч. сотрудник, лаборатория онковирусологии.

634050, г. Томск, пер. Кооперативный, 5 ; 634050, г. Томск, пр. Ленина, 36.

Ibragimova Marina K., Junior Researcher, Laboratory of Oncovirology, Cancer Research Institute.

 

Imk1805@yandex.ruЦыгановМ. М.TsyganovM. M.

Цыганов Матвей Михайлович, канд. биол. наук, мл. науч. сотрудник, лаборатория онковирусологии.

634050, г. Томск, пер. Кооперативный, 5 .

Tsyganov Matvey M., PhD, Junior Researcher, Laboratory of Oncovirology, Cancer Research Institute.

5, Kooperativny Str., Tomsk, 634050.

ТарабановскаяН. А.TarabanovskayaN. A.

ИМЦ РАН,  г. Томск. Тарабановская Наталья Анатольевна, канд. мед. наук, науч. сотрудник, отделение общей онкологии.

634050, г. Томск, пер. Кооперативный, 5 .

Tarabanovskaya Natalia A., PhD, Researcher,  Department of General Oncology, Cancer Research Institute.

5, Kooperativny Str., Tomsk, 634050.

ТаширеваЛ. А.TashirevaL. A.

Таширева Любовь Александровна, канд. мед. наук, ст. науч. сотрудник, отделение патологической анатомии и цитологии.

 

Tashireva Lubov A., PhD, Senior Researcher,  Department of Pathological Anatomy and Cytology, Cancer Research Institute.

5, Kooperativny Str., Tomsk, 634050.

ДерюшеваИ. В.DeryushevaI. V.

Дерюшева Ирина Валерьевна, мл. науч. сотрудник, лаборатория онковирусологии.

 

Deryusheva Irina V., Junior Researcher, Laboratory of Oncovirology, Cancer Research Institute.

5, Kooperativny Str., Tomsk, 634050.

ПерельмутерВ. М.PerelmuterV. M.

Перельмутер Владимир Михайлович, д-р мед. наук, профессор, зав. отделением патологической анатомии и цитологии.

 

Perelmuter Vladimir M., DM, Professor, Head of the Department of Pathological Anatomy and Cytology, Cancer Research Institute.

5, Kooperativny Str., Tomsk, 634050.

СлонимскаяЕ. М.SlonimskayaE. M.

Слонимская Елена Михайловна, д-р мед. наук, профессор, зав. отделением общей онкологии.

634050, г. Томск, пер. Кооперативный, 5; 634050, г. Томск, Московский тракт, 2

Slonimskaya Elena M., DM, Professor, Head of the Department of General Oncology, Cancer Research Institute.

5, Kooperativny Str., Tomsk, 634050; 2, Moskovsky Tract, Tomsk, 634050.

ЛитвяковН. В.LitviakovN. V.

Литвяков Николай Васильевич, д-р биол. наук, зав. лабораторией онковирусологии.

634050, г. Томск, пер. Кооперативный, 5 ; 634050, г. Томск, пр. Ленина, 36.

Litviakov Nikolai V., DBSc, Head of the Laboratory Oncovirology, Cancer Research Institute.

5, Kooperativny Str., Tomsk, 634050; 36, Lenina Av., Tomsk, 634050.

Научно-исследовательский институт (НИИ) онкологии, Томский национальный исследовательский медицинский центр (ТНИМЦ) Российской академии наук (РАН) ; Национальный исследовательский Томский государственный университет (НИ ТГУ).РоссияCancer Research Institute, Tomsk National Research Medical Center (TNRMC) of Russian Academy of Sciences (RAS) ; National Research Tomsk State University (NR TSU).Russian FederationНаучно-исследовательский институт (НИИ) онкологии, Томский национальный исследовательский медицинский центр (ТНИМЦ) Российской академии наук (РАН).РоссияCancer Research Institute, Tomsk National Research Medical Center (TNRMC) of Russian Academy of Sciences (RAS) .Russian FederationНаучно-исследовательский институт (НИИ) онкологии, Томский национальный исследовательский медицинский центр (ТНИМЦ) Российской академии наук (РАН); Сибирский государственный медицинский университет (СибГМУ).РоссияCancer Research Institute, Tomsk National Research Medical Center (TNRMC) of Russian Academy of Sciences (RAS); Siberian State Medical University (SSMU).Russian Federation201830032018171232238Copyright © Ибрагимова М.К., Цыганов М.М., Тарабановская Н.А., Таширева Л.А., Дерюшева И.В., Перельмутер В.М., Слонимская Е.М., Литвяков Н.В., 20182018Ибрагимова М.К., Цыганов М.М., Тарабановская Н.А., Таширева Л.А., Дерюшева И.В., Перельмутер В.М., Слонимская Е.М., Литвяков Н.В.Ibragimova M.K., Tsyganov M.M., Tarabanovskaya N.A., Tashireva L.A., Deryusheva I.V., Perelmuter V.M., Slonimskaya E.M., Litviakov N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/1133

В настоящей работе рассматривается уникальный случай ВПЧ-позитивной (тип 16) опухоли молочной железы. Наличие ВПЧ-инфекции в опухоли подтверждено двумя независимыми методами – полимеразной цепной реакции и иммуногистохимии. Показано, что при наличии неблагоприятных факторов прогноза, таких как лимфогенное метастазирование, высокий уровень экспрессии Ki67, хромотрипсис в опухоли и высокий уровень генетической нестабильности у пациентки с ВПЧ-позитивной опухолью молочной железы, возможна более чем 8-летняя безрецидивная выживаемость, что согласуется с данными по благоприятному исходу ВПЧ-позитивного рака шейки матки и гортани по сравнению с ВПЧ-негативными случаями.

In this manuscript, a unique case of HPV16-positive breast cancer is examined. The presence of HPV infection in the tumor is confirmed by two independent methods (PCR and immunohistochemistry). It is shown that in the presence of adverse factors of prognosis (lymphogenous metastasis, high level of Ki67 expression, presence of chromotrypsis in the tumor, and high level of genetic instability), a patient with a HPV-positive breast tumor has more than 8-year disease-free survival.

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The authors declare that there are no conflicts of interest present.