ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2018-2-114-120ssmu-1209Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESЗначение эпидермального барьера и сенсибилизации к бытовым аллергенам на развитие атопического марша в обосновании первичной профилактикиSignificance of the epidermal barrier and sensitisation to household allergens to the development of atopic march for primary preventionВарламовЕ. Е.VarlamovE. E.

канд. мед. наук, ст. науч. сотрудник, зав. отделением аллергологии и клинической иммунологии,

125412, г. Москва, ул. Талдомская, 2

PhD, Senior Researcher, Department Allergology and Clinical Immunology,

2, Taldomskaya Str., Moscow, 125412

varlamov80@mail.ruПампураА. Н.PampuraA. N.

д-р мед. наук, зав. отделением отделения аллергологии и клинической иммунологии,

125412, г. Москва, ул. Талдомская, 2

DM, Head of the Department Allergology and Clinical Immunology,

2, Taldomskaya Str., Moscow, 125412

АсмановА. И.AsmanovA. N.

канд. мед. наук, руководитель научного отдела острой и хронической патологии уха, горла и носа,

125412, г. Москва, ул. Талдомская, 2

PhD, Head of the Department Otolaryngology,

2, Taldomskaya Str., Moscow, 125412

Научно-исследовательский клинический институт педиатрии имени академика Ю.Е. Вельтищева, РНИМУ имени Н.И. ПироговаРоссияRussian National Research Medical University named after N.I. Pirogov, Clinical Research Institute of PediatricsRussian Federation201820072018172114120Copyright © Варламов Е.Е., Пампура А.Н., Асманов А.И., 20182018Варламов Е.Е., Пампура А.Н., Асманов А.И.Varlamov E.E., Pampura A.N., Asmanov A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/1209

Атопический марш – вариант течения атопии, характеризующийся, как правило, началом атопического дерматита в раннем детском возрасте с последующим развитием других аллергических заболеваний (бронхиальной астмы, аллергического ринита) в более старшем возрасте. В качестве основных возможных предикторов атопического марша выделяют состояние эпидермального барьера и наличие сенсибилизации к ингаляционным аллергенам. В статье представлены данные о значении данных факторов в развитии атопического марша и дана информация о возможных подходах к профилактике.

Atopic march is a variant flowing of atopia that begins in early childhood as atopic dermatitis, then developinto other allergic diseases (bronchial asthma, allergic rhinitis) at an older age. The state of the epidermal barrier and sensitization to inhaled allergens are considered as predictors for the development of atopic march. Data on the importance of these factors in the development of atopic march and information about possible approaches to prevention are presented in this article.

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The authors declare that there are no conflicts of interest present.