References

ssmu

Бюллетень сибирской медицины

Bulletin of Siberian Medicine

1682-03631819-3684

Siberian State Medical University, the Ministry of Healthcare of the Russian Federation

10.20538/1682-0363-2018-3-217-228

ssmu-1301

Research Article

ОБЗОРЫ И ЛЕКЦИИ

REVIEW AND LECTURES

Моделирование микроокружения мезенхимных стволовых клеток как перспективный подход к тканевой инженерии и регенеративной медицине (краткий обзор)

Modeling of the mesenchymal stem cell microenvironment as a prospective approach to tissue bioengineering and regenerative medicine (a short review)

https://orcid.org/0000-0003-3465-8452

Хлусов

И. А.

Khlusov

I. A.

Хлусов Игорь Альбертович - докторр медицинских наук, профессор, кафедра морфологии и общей патологии, СибГМУ; старший научный сотрудник, НИ ТГУ, Томск; профессор-исследователь, БФУ им. И. Канта.

634050, Томск, Московский тракт, 2; 634050, Томск, пр. Ленина, 36; 236041, Калининград, ул. А. Невского, 14

Khlusov Igor A. - DM, Professor, Department of Morphology and General Pathology, SSMU; NR TSU, Tomsk; Immanuel Kant BFU.

2, Mosсow Tract, Tomsk, 634050; 36, Lenina Av., Tomsk, 634050; 14, Nevskogo Str., Kaliningrad, 236041

khlusov63@mail.ru

https://orcid.org/0000-0001-5231-6910

Литвинова

Л. С.

Litvinova

L. S.

Литвинова Лариса Сергеевна - докторр медицинских наук, зав. базовой лабораторией иммунологии и клеточных биотехнологий, БФУ им. И. Канта.

236041, Калининград, ул. А. Невского, 14

Litvinova Larisa S. - DM, Head of Base Laboratory Immunology and Cell Biotechnology.

14, Nevskogo Str., Kaliningrad, 236041

https://orcid.org/0000-0001-6146-3330

Юрова

К. А.

Yurova

K. A.

Юрова Кристина Алексеевна - кандидат медицинских наук, научный сотрудник, базовая лаборатория иммунологии и клеточных биотехнологий, БФУ им. И. Канта.

236041, Калининград, ул. А. Невского, 14

Yurova Kristina A. - PhD, Researcher, Base Laboratory Immunology and Cell Biotechnology.

14, Nevskogo Str., Kaliningrad, 236041

https://orcid.org/0000-0002-8987-0664

Мелащенко

Е. С.

Melashchenko

E. S.

Мелащенко Елена Сергеевна - аспирант, лаборант, базовая лаборатория иммунологии и клеточных биотехнологий, БФУ им. И. Канта.

236041, Калининград, ул. А. Невского, 14

Melashchenko Elena S. - Laboratory Аssistant, Base Laboratory Immunology and Cell Biotechnology.

14, Nevskogo Str., Kaliningrad, 236041

https://orcid.org/0000-0002-5525-3529

Хазиахматова

О. Г.

Khaziakhmatova

O. G.

Хазиахматова Ольга Геннадьевна - кандидат биологических наук, научный сотрудник, базовая лаборатория иммунологии и клеточных биотехнологий, БФУ им. И. Канта.

236041, Калининград, ул. А. Невского, 14

Khaziakhmatova Olga G. - PhD, Researcher, Base Laboratory Immunology and Cell Biotechnology.

14, Nevskogo Str., Kaliningrad, 236041

Шуплецова

В. В.

Shupletsova

V. V.

Шуплецова Валерия Владимировна - кандидат биологических наук, научный сотрудник, базовая лаборатория иммунологии и клеточных биотехнологий.

236041, Калининград, ул. А. Невского, 14

Shupletsova Valeria V. - PhD, Researcher, Laboratory Immunology and Cell Biotechnology.

14, Nevskogo Str., Kaliningrad, 236041

https://orcid.org/0000-0001-9583-5358

Хлусова

М. Ю.

Khlusova

M. Yu.

Хлусова Марина Юрьевна, кандидат медицинских наук, доцент, кафедра патофизиологии, СибГМУ.

634050, Томск, Московский тракт, 2

Khlusova Marina Yu. - PhD, Аssistant Рrofessor, Department of Pathophysiology.

2, Mosсow Tract, Tomsk, 634050

Сибирский государственный медицинский университет (СибГМУ); Национальный исследовательский Томский государственный университет (НИ ТГУ); Балтийский федеральный университет имени (БФУ) И. КантаРоссияSiberian State Medical University (SSMU); National Research Tomsk State University (NR TSU); Immanuel Kant Baltic Federal University (BFU)Russian Federation

Балтийский федеральный университет имени (БФУ) И. КантаРоссияImmanuel Kant Baltic Federal University (BFU)Russian Federation

Сибирский государственный медицинский университет (СибГМУ)РоссияSiberian State Medical University (SSMU)Russian Federation

2018

29092018

173217228

2018

Хлусов И.А., Литвинова Л.С., Юрова К.А., Мелащенко Е.С., Хазиахматова О.Г., Шуплецова В.В., Хлусова М.Ю.

Khlusov I.A., Litvinova L.S., Yurova K.A., Melashchenko E.S., Khaziakhmatova O.G., Shupletsova V.V., Khlusova M.Y.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://bulletin.ssmu.ru/jour/article/view/1301

Одним из перспективных направлений являются разработка и модификация материалов для контроля жизнедеятельности мультипотентных мезенхимных стромальных клеток (ММСК), которые (ре)конструируют строму различных органов и тканей человека и животных. Тем не менее обсуждение вопроса о существовании и функционировании микроокружения ММСК только начинается. Это тормозит дальнейшее развитие клеточной биологии и тканевой инженерии. Дизайн искусственных материалов, способных к биомиметическому воспроизведению клеточного и тканевого микроокружения, основанный на идеях и элементах, заимствованных у природы, является современным направлением в развитии медицинского материаловедения и тканевой инженерии. Скеффолд-технологии – многообещающий экспериментальный подход к моделированию свойств природного микроокружения для стволовых клеток. Цель – краткий обзор ключевых элементов микротерриторий ММСК, его перспективных исследований и попыток моделирования в приложении к тканевой инженерии и регенеративной медицине.

One of the promising areas is the design and modification of materials for control over the fate of multipotent mesenchymal stromal cells (MMSCs) that will allow stroma of various human and animal organs and tissues to be constructed. However, the discussion about the existence and functioning of microenvironment for the MMSCs is just beginning to develop. The design of artificial materials that are able to reproduce biomimetically the cellular and tissue microenvironment and based on ideas and main elements borrowed from wildlife is current direction in a development of medical materials technology and tissue bioengineering. Scaffold technology is a promising experimental approach to simulate the properties of natural microenvironment of stem cells. Our aim is a short review of key elements of MMSC microterritories, its advanced investigations and the attempts of modeling in application to tissue bioengineering and regenerative medicine.

стволовые клеткимикроокружениеэкстрацеллюлярный матриксбиоматериалыкостьбиоинженерия

stem cellsmicroenvironmentextracellular matrixbiomaterialsbonebioengineering

Минобрнауки России, соглашение № 14.575.21.0164 от 26.09.17 (уникальный идентификатор RFMEFI57517Х0164) в рамках Федеральной целевой программы «Исследования и разработки по приоритетным направлениям развития научно-технологического комплекса России на 2014– 2020 годы»

Federal Target Program of the Ministry of Education and Science of the Russian Federation (agreement 14.575.21.0164, ID number RFMEFI57517X0164) “Research and innovations in priority areas of development of Russian scientific and technological complex for 2014–2020”

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The authors declare that there are no conflicts of interest present.