ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2011-2-26-29ssmu-1354Research ArticleЭКСПЕРИМЕНТАЛЬНЫЕ И КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯEXPERIMENTAL AND CLINICAL INVESTIGATIONSМатриксная металлопротеиназа-9, супероксиддисмутаза и перекисное окисление липидов у недоношенных новорожденных с перинатальной гипоксиейMatrix metalloproteinase 9, superoxide dismutase and lipid peroxidation in preterm newborns with perinatal hypoxiaКореновскийЮ. В.KorenovskyYu. V.

Кореновский Юрий Владимирович, канд. мед. наук, ассистент кафедры биохимии и клинической лабораторной диагностики 

тел.: (3852) 26-07-02

timidin@gmail.comЕльчаниноваС. А.ElchaninovaS. A.

д-р биол. наук, профессор, зав. кафедрой биохимии и клинической лабораторной диагностики

ФадееваН. И.FadeyevaN. I.

д-р мед. наук, профессор, зав. кафедрой акушерства и гинекологии № 1

Алтайский государственный медицинский университетRussian Federation2011280420111022629Copyright © Кореновский Ю.В., Ельчанинова С.А., Фадеева Н.И., 20112011Кореновский Ю.В., Ельчанинова С.А., Фадеева Н.И.Korenovsky Y.V., Elchaninova S.A., Fadeyeva N.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/1354

У недоношенных новорожденных перинатальная гипоксия (ПГ) ассоциируется с повышенными уровнями матриксной металлопротеиназы-9 (MMП-9), супероксиддисмутазы (СОД) и тиобарбитурат-реактивных продуктов в плазме пуповинной крови. Тяжесть ПГ по шкале Апгар коррелировала с СОД (r = –0,40; p = 0,006) и ММП-9 (r = 0,36; p = 0,023). Предполагается, что повышение СОД препятствует активации активными формами кислорода ММП-9, разрушающей коллаген базальной мембраны гематоэнцефалического барьера.

The perinatal hypoxia (PH) in preterm newborns is associated with elevated levels of matrix metalloproteinase 9 (MMP-9), superoxide dismutase (SOD) and thiobarbituric acid reactive substances in umbilical cord blood plasma. The severity of PH Apgar scores correlated with SOD (r = –0,40; p = 0,006) and MMP-9 (r = 0,36; p = 0,023). It is assumed that the SOD increase prevents the reactive oxygen species mediated activation of MMP-9, which destroy the collagen of the basement membrane of the bloodbrain barrier.

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The authors declare that there are no conflicts of interest present.