ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2011-4-93-98ssmu-1435Research ArticleОБЗОР ЛИТЕРАТУРЫLITERATURE REVIEWМолекулярные аспекты функционирования T-хелперов 17-го типаMolecular aspects of the T-helpers type 17 functioningКологривоваИ. В.KologrivovaI. V.

Кологривова Ирина Вячеславовна, науч. сотрудник отделения функциональной и лабораторной диагностики 

тел.: 8 (3822) 55-83-85; 8-913-105-3869

ikologrivova@gmail.comКологривоваЕ. Н.KologrivovaYe. N.

д-р мед. наук, профессор кафедры иммунологии и аллергологии

СусловаТ. Е.SuslovaT. Ye.

канд. мед. наук, вед. науч. сотрудник отделения функциональной и лабораторной диагностики

НИИ кардиологии СО РАМНRussian FederationСибирский государственный медицинский университетRussian Federation2011280820111049398Copyright © Кологривова И.В., Кологривова Е.Н., Суслова Т.Е., 20112011Кологривова И.В., Кологривова Е.Н., Суслова Т.Е.Kologrivova I.V., Kologrivova Y.N., Suslova T.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/1435

Представлены современные научные данные о функционировании Т-хелперов 17-го типа (Th17). Описывается история открытия Th17, транскрипционные факторы, а также механизмы, опосредующие стимуляцию и ингибирование дифференцировки Th17. Перечислены цитокины, продуцируемые данной лимфоцитарной субпопуляцией, и сигнальные пути, за счет которых реализуются их эффекты. Дается краткое описание физиологических процессов и заболеваний, в развитии которых доказано участие Th17.

The article presents up-to-date data on the functioning of the T-helper type 17 (Th17). History of the Th17 discovery, transcription factors, mechanisms, mediating stimulation and inhibition of the Th17 differentiation, are described. Cytokines, which are produced by this lymphoid subset, and signaling pathways, through which its effects are realized, are listed. A brief description is given of the main physiological processes and diseases, in which participation of the Th17 was described.

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The authors declare that there are no conflicts of interest present.