ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2015-1-102-109ssmu-146Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESРОЛЬ ГЕНЕТИЧЕСКИХ ФАКТОРОВ В МЕХАНИЗМАХ РАЗВИТИЯ РЕМОДЕЛИРОВАНИЯ КОРОНАРНЫХ АРТЕРИЙ ПОСЛЕ ИМПЛАНТИРОВАНИЯ СТЕНТОВTHE ROLE OF GENETIC FACTORS IN THE MECHANISM OF CORONARY ARTERY REMODELING AFTER IMPLANTATION OF STENTSВинтизенкоС. И.VintizenkoS. I.

Винтизенко Станислав Игоревич, кандидат медицинских наук, врач-рентгенолог отделения рентгенохирургических методов диагностики и лечения

Vintizenko Stanislav I.

vvi@cardio.tsu.ruОгородоваЛ. М.OgorodovaL. M.

Огородова Людмила Михайловна, доктор медицинских наук, профессор, член-корреспондент РАМН, зав. кафедрой факультетской педиатрии СибГМУ

Ogorodova Lyudmila M.

vvi@cardio.tsu.ruРукинК. Ю.RukinK. Yu.

Рукин Константин Юрьевич, аспирант ЦНИЛ СибГМУ

Rukin Konstantin Yu.

vvi@cardio.tsu.ruПетроваИ. В.PetrovaI. V.

Петрова Ирина Валерьевна, кандидат медицинских наук, старий научный сотрудник ЦНИЛ СибГМУ

Petrova Irina V.

vvi@cardio.tsu.ruНаучно-исследовательский институт кардиологии, ТомскРоссияResearch Institute for Сardiology, TomskRussian FederationСибирский государственный медицинский университет, ТомскРоссияSiberian State Medical UniversityRussian Federation201528022015141102109Copyright © Винтизенко С.И., Огородова Л.М., Рукин К.Ю., Петрова И.В., 20152015Винтизенко С.И., Огородова Л.М., Рукин К.Ю., Петрова И.В.Vintizenko S.I., Ogorodova L.M., Rukin K.Y., Petrova I.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/146

В последнее десятилетие в мире значительно выросла частота применения эндопротезирования при лечении лиц, страдающих ишемической болезнью сердца (ИБС). Коронарная ангиопластика со стентированием значительно расширила возможности и повысила эффективность лечения ИБС. Тем не менее важным фактором, ограничивающим эффективность эндоваскулярного лечения, остается развитие рестенозастентированного участка. В статье представлен обзор наиболее изученных полиморфизмов генов системы гемостаза, системы воспаления, ренин-ангиотензиновой системы, эндотелиальной синтазы оксида азота, которые могут играть ключевую роль в развитии рестеноза в стенте. Исследования в этом направлении являются существенными и могут помочь в понимании механизмов и стратификации риска развития рестеноза после ангиопластики.

In the last 10 years the World has increased significantly the frequency of joint replacement in patients with coronary artery disease. Coronary angioplasty with stenting significantly improve the capacity and effectiveness of the treatment of coronary artery disease. However, an important factor limiting the effectiveness of endovascular treatment of restenosis remains the stented area.The article presents an overview of the most studied gene polymorphisms of hemostasis, inflammation system, the renin-angiotensin system, endothelial nitric oxide synthase, which can play a key role in the development of in-stent restenosis. Research in this area are significant and may help in understanding the mechanisms and risk stratification of restenosis after angioplasty.

рестенознегативное ремоделированиегеныишемическая болезнь сердцаrestenosisnegative remodelinggenescoronary heart diseaseReferencesБокерия Л.А., Гудкова Р.Г. и др. Болезни и врожденные аномалии системы кровообращения // Сердечно-сосу-дистая хирургия. 2005. С. 4–29.Bokeria L.A., Gudkova R.G. et al. Bolezni i vrozhdennye anomalii sistemy krovoobrascheniya [Diseases and congenital anomalies of the circulatory system]. Serdechno-sosudistaja hirurgija – Cardiovascular surgery, 2005, pp. 4–29 (in Russian).Бокерия Л.А., Алекян Б.Г. Рентгеноэндоваскулярная хирургия ишемической болезни сердца: руководство для врачей. М.: НЦССХ им. А.Н. Бакулева РАМН, 2008. 88 с.Bokeria L.A., Alekyan B.G. Rentgenoendovaskulyarnaya hirurgiya ishemicheskoy bolezni serdca: rukovodstvo dlya vrachey [Endovascular surgery of coronary heart disease: a guide for physicians]. Moscow, 2008. 88 p. (in Russian).Дашкова А.А., Чумакова Г.А. Роль полиморфизма некоторых генов системы гемостаза и фолатного цикла в возникновении рестеноза у пациентов с хронической ишемической болезнью сердца после коронарного стентирования // Вестн. Рос. гос. мед. ун-та. 2012. Спецвып. 1. С. 115–116.Dashkova A.A., Chumakova G.A. Rol' polimorfizma nekotoryh genov sistemy gemostaza i folatnogo cikla v vozniknovenii restenoza u pacientov s hronicheskoy ishemicheskoy bolezn'yu serdca posle koronarnogo stentirovaniya [The role of some genes polymorphism of the hemostatic system and folate cycle in occurrence of restenosis in patients with chronic coronary heart disease after coronary stenting]. Vestnik Rossijskogo gosudarstvennogo medicinskogo universiteta – Bulletin of Russian State Medical University, 2012, Special issue 1, pp. 115–116 (in Russian).Шувалова Ю.А., Каминный А.И., Мешков А.Н. Полиморфизмы генов ENOS и GPX-1 ассоциированы с риском развития рестеноза после стентирования коронарных ар-терий непокрытами стентами // Междунар. журн. интервенционной кардиоангиологии. 2011. Вып. 25. C. 47–50.Shuvalova Yu.A., Kaminnyj A.I., Meshkov A.N. Polimorfizmy genov ENOS i GPX-1 associirovany s riskom razvitiya restenoza posle stentirovaniya koronarnyh arteriy nepokrytami stentami [Polymorphisms in eNOS and Gpx-1 Genes are Asociated with the Risk of Restenosis after Coronary Stenting with Bare Metal Stentss]. Mezhdunarodnyi zhurnal intervencionnoy kardioangiologii – International Journal of Interventional Cardioangiology, 2011, issue 25, pp. 57–63 (in Russian).Babu B.M., Reddy B.P., Priya V.H. et al.Cytokine gene poly-morphisms in the susceptibility to acute coronary syndrome // Genet. Test. Mol. Biomarkers. 2012. V. 16 (5). P. 359–365.Babu B.M., Reddy B.P., Priya V.H. et al. Cytokine gene polymorphisms in the susceptibility to acute coronary syndrome. Genet. Test. Mol. Biomarkers, 2012, vol. 16 (5), pp. 359–365.Calvette J.J. On the structure and function of platelet integrin αIIbβ3, the fibrinogen receptor // Proc. Soc. Exp. Biol. Med. 1995. V. 208. P. 346–360.Calvette J.J. On the structure and function of platelet integrin αIIbβ3, the fibrinogen receptor. Proc. Soc. Exp. Biol. Med., 1995, vol. 208, pp. 346–360.Chandrasekar B., Tanguay J-F. Platelets and restenosis // J. Am. Coll. Cardiol. 2000. V. 35. P. 555–562.Chandrasekar B., Tanguay J-F. Platelets and restenosis. J. Am. Coll. Cardiol., 2000, vol. 35, pp. 555–562.Ding Y.A., Macintyre D.E., Kenyon C.J. et al. Potentiation of adrenaline-induced platelet aggregation by angiotensin II // Thromb. Haemost. 1985. V. 54. P. 717–720.Ding Y.A., Macintyre D.E., Kenyon C.J. et al. Potentiation of adrenalineinduced platelet aggregation by angiotensin II. Thromb. Haemost. 1985, vol. 54, pp. 717–720.Exner M., Schillinger M., Minar E. et al. Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with restenosis after percutaneous transluminal angioplasty // J. Endovasc. Ther. 2001. V. 8. P. 433–440.Exner M., Schillinger M., Minar E. et al. Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with restenosis after percutaneous transluminal angioplasty. J. Endovasc. Ther., 2001, vol. 8, pp. 433–440.Farb A., Sangiorgi G., Carter A.J. et al. Pathology of acute and chronic coronary stenting in humans // Circulation. 1999. V. 99. P. 44–52.Farb A., Sangiorgi G., Carter A.J. et al. Pathology of acute and chronic coronary stenting in humans. Circulation, 1999, vol. 99, pp. 44–52.Gao J., CuiR. Z., Liu Y., Mao Y.M., Zhou J. et al. Relationship of interleukin-10 gene polymorphism with restenosis after percutaneous coronary intervention in Chinese // Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2011. V. 28 (1). P. 42–46.Gao J., CuiR. Z., Liu Y., Mao Y.M., Zhou J. et al. Relationship of interleukin-10 gene polymorphism with restenosis after percutaneous coronary intervention in Chinese. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2011, vol. 28. (1), pp. 42–46.Gawaz M., Neumann F.J., Ott I. et al. Changes in membrane glycoproteins of circulating platelets after coronary stent im-plantation // Heart. 1996. V. 76. P. 166–172.Gawaz M., Neumann F.J., Ott I. et al. Changes in membrane glycoproteins of circulating platelets after coronary stent implantation. Heart, 1996, vol. 76, pp. 166–172.Ghazouani L., Khalifa S.B., Abboud N., Addad F. et al.-308G>A and -1031T>C tumor necrosis factor gene poly-morphisms in Tunisian patients with coronary artery disease // Clin. Chem. Lab. Med. 2009. V. 47 (10). P. 1247–1251.Ghazouani L., Khalifa S.B., Abboud N., Addad F. et al.-308G>A and -1031T>C tumor necrosis factor gene polymorphisms in Tunisian patients with coronary artery disease. Clin. Lab. Med., 2009, vol. 47. (10), pp. 1247–1251.Gomma A.H., Elrayess M.A., Knight C.J. et al. The endothe-lial nitric oxide synthase (Glu298Asp and -786T>C) gene polymorphism are associated with coronary in-stent restenosis // Eur. Heart J. 2002. V. 23. P. 1955–1962.Gomma A.H., Elrayess M.A., Knight C.J. et al. The endothelial nitric oxide synthase (Glu298Asp and -786T>C) gene polymorphism are associated with coronary in-stent restenosis. Eur. Heart J., 2002, vol. 23, pp. 1955–1962.Gulesserian T., Wenzel C., Endler G. et al. Clinical Resteno-sis after Coronary Stent Implantation Is Associated with the Heme Oxygenase-1 Gene Promoter Polymorphism and the Heme Oxygenase-1 -99G/C Variant // Clinical Chemistry. 2005. V. 51 (9). P. 1661–1665.Gulesserian T., Wenzel C., Endler G. et al. Clinical Restenosis after Coronary Stent Implantation Is Associated with the Heme Oxygenase-1 Gene Promoter Polymorphism and the Heme Oxygenase-1 -99G/C Variant. Clinical Chemistry, 2005, vol. 51 (9), pp. 1661–1665.Hertwig S., Volzke H., Robinson D.M. et al. Angiotensinogen M235T polymorphism and recurrent restenosis after repeated percutaneous transluminal coronary angioplasty // Clin. Sci. 2002. V. 103. P. 101–106.Hertwig S., Volzke H., Robinson D.M. et al. Angiotensinogen M235T polymorphism and recurrent restenosis after repeated percutaneous transluminal coronary angioplasty. Clin. Sci., 2002, vol. 103, pp. 101–106.Hibi K., Ishigami T., Tamura K. et al. Endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction // Hypertension. 1998. V. 32. P. 521–526.Hibi K., Ishigami T., Tamura K. et al. Endothelial nitric ox ide synthase gene polymorphism and acute myocardial infarction. Hypertension, 1998, vol. 32, pp. 521–526.Horibe H., Yamada Y., Ichihara S. et al. Genetic risk for restenosis after coronary ballon angioplasty // Aterosclerosis. 2004. V. 174. P. 181–187.Horibe H., Yamada Y., Ichihara S. et al. Genetic risk for restenosis after coronary ballon angioplasty. Aterosclerosis, 2004, vol. 174, pp. 181–187.Itoh H., Mukoyama M., Pratt R.E. et al. Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin II // J. Clin. Invest. 1993. V. 91. P. 2268–2274.Itoh H., Mukoyama M., Pratt R.E. et al. Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin II. J. Clin. Invest, 1993, vol. 91, pp. 2268–2274.Koch W., Tiroch K., von Beckerath N., Schömig A. et al. Tumor necrosis factor-alpha, lymphotoxin-alpha, and inter-leukin-10 gene polymorphisms and restenosis after coronary artery stenting // Cytokine. 2003. V. 24 (4). P. 161–171.Koch W., Tiroch K., von Beckerath N., Schömig A. et al. Tumor necrosis factor-alpha, lymphotoxin-alpha, and interleukin-10 gene polymorphisms and restenosis after coronary artery stenting. Cytokine, 2003, vol. 24 (4), pp. 161–171.Le Tourneau T., Van Belle E., Corseaux D. et al. Role of ni-tric oxide in restenosis after experimental balloon angioplasty in the hypercholesterolemic rabbit: effects on neointimal hyperplasia and vascular remodeling // J. Am. Coll. Cardiol. 1999. V. 33. P. 876–882.Le Tourneau T., Van Belle E., Corseaux D. et al. Role of nitric oxide in restenosis after experimental balloon angioplasty in the hypercholesterolemic rabbit: effects on neointimal hyperplasia and vascular remodeling. J. Am. Coll. Cardiol., 1999, vol. 33, рр.876–882.Li P., Gomma M.A., Palmen J., Hawe E. et al. The microsat-ellite polymorphism of heme oxygenase-1 is associated with baseline plasma IL-6 level but not with restenosis after coro-nary in-stenting // Chin. Med. J. 2005. V. 118 (18). P. 1525–1532.Li P., Gomma M.A., Palmen J., Hawe E. et al. The microsatellite polymorphism of heme oxygenase-1 is associated with baseline plasma IL-6 level but not with restenosis after coronary in-stenting. Chin. Med. J., 2005, vol. 118 (18), pp. 1525–1532.Lindpaintner K., Pfeffer M.A., Kreutz R. et al. A prospective evaluation of an angiotensin converting enzyme gene poly-morphism and the risk of ischemic heart disease // N. Engl. J. Med. 1995. V. 332. P. 706–711.Lindpaintner K., Pfeffer M.A., Kreutz R. et al. A prospective evaluation of an angiotensin converting enzyme gene polymorphism and the risk of ischemic heart disease. N. Engl. J. Med., 1995, vol. 332, рр.706–711.Mackness M.I., Arrol S., Durrington P.N. Paraoxonase pre-vents accumulation of lipoperoxides in low-density lipoprotein // FEBS Lett. 1991. V. 286. P. 152–154.Mackness M.I., Arrol S., Durrington P.N. Paraoxonase prevents accumulation of lipoperoxides in low-density lipoprotein. FEBS Lett., 1991, vol. 286, pp. 152–154.Mintz G.S., Popma J.J., Pichard A.D. et al. Arterial remodel-ing after coronary angioplasty: a serial intravascular ultra-sound study // Circulation. 1996. V. 94. P. 35–43.Mintz G.S., Popma J.J., Pichard A.D. et al. Arterial remodeling after coronary angioplasty: a serial intravascular ultrasound study. Circulation, 1996, vol. 94, pp. 35–43.Oike Y., Hata A., Ogata Y. et al. Angiotensin converting en-zyme as a genetic risk factor for coronary artery spasm. Im-plication in the pathogenesis of myocardial infarction // J. Clin. Invest. 1995. V. 96. P. 2975–2979.Oike Y., Hata A., Ogata Y. et al. Angiotensin converting enzyme as a genetic risk factor for coronary artery spasm. Implication in the pathogenesis of myocardial infarction. J. Clin. Invest, 1995, vol. 96, pp. 2975–2979.Pereira T.V., Rudnicki M., Franco R.F., Pereira A.C. et al. Effect of the G-308A polymorphism of the tumor necrosis factor alpha gene on the risk of ischemic heart disease and is-chemic stroke: a meta-analysis // Am. Heart J. 2007. V. 153. P. 821–830.Pereira TV., Rudnicki M., Franco R.F., Pereira A.C. et al. Effect of the G-308A polymorphism of the tumor necrosis factor alpha gene on the risk of ischemic heart disease and ischemic stroke: a meta-analysis. Am. Heart J., 2007, vol. 153, pp. 821–830.Prisco D., Fatini C., Battaglini B. et al. Angiotensin convert-ing enzyme DD genotype affects the changes of plasma plasminogen activator inhibitor-1 activity after primary per-cutaneous transluminal coronary angioplasty in acute myo-cardial infarction patients // Int. J. Clin. Lab. Res. 2000. V. 30. P. 179–85.Prisco D., Fatini C., Battaglini B. et al. Angiotensin converting enzyme DD genotype affects the changes of plasma plasminogen activator inhibitor-1 activity after primary percutaneous transluminal coronary angioplasty in acute myocardial infarction patients. Int. J. Clin. Lab. Res., 2000, vol. 30, pp. 179–85.Rakugi H., Jacob H.J., Krieger J.E. et al. Vascular injury in-duces angiotensinogen gene expression in the media and neointima // Circulation. 1993. V. 87. P. 283–290.Rakugi H., Jacob H.J., Krieger J.E. et al. Vascular injury induces angiotensinogen gene expression in the media and neointima. Circulation, 1993, vol. 87, pp. 283–290.Ribichini F., Ferrero V., Matullo G., Feola M. et al. Asso-ciation study of the I/D polymorphism and plasma angioten-sin-converting enzyme (ACE) as risk factors for stent reste-nosis // Clin. Sci. 2004. V. 107 (4). P. 381–389.Ribichini F., Ferrero V., Matullo G., Feola M. et al. Association study of the I/D polymorphism and plasma angiotensinconverting enzyme (ACE) as risk factors for stent restenosis. Clin. Sci., 2004, vol. 107 (4), pp. 381–389.Ryu S.K., Cho E.Y., Park H.Y., Im E.K. et al. Renin-angiotensin-aldosterone system (RAAS) gene polymorphism as a risk factor of coronary in-stent restenosis // Yonsei Med. J. 2002. V. 43. (4). P. 461–472.Ryu S.K., Cho E.Y., Park H.Y., Im E.K. et al. Reninangiotensin-aldosterone system (RAAS) gene polymorphism as a risk factor of coronary in-stent restenosis. Yonsei Med. J., 2002, vol. 43. (4), pp. 461–472.Samani N.J., Thompson J.R., O`Toole L. et al. A meta-analysis of the association of the deletion allele of the angio-tensin converting enzyme gene with myocardial infarction // Circulation. 1996. V. 94. P. 708–712.Samani N.J., Thompson J.R., O`Toole L. et al. A metaanalysis of the association of the deletion allele of the angiotensin converting enzyme gene with myocardial infarction. Circulation, 1996, vol. 94, pp. 708–712.Sanghera D.K., Saha N., Aston C.E., Kamboh M.I. Genetic polymorphism of paraoxonase and the risk of coronary artery disease // Arterioscler. Thromb. Vasc. Biol. 1997. V. 17. P. 1067–1073.Sanghera D.K., Saha N., Aston C.E., Kamboh M.I. Genetic polymorphism of paraoxonase and the risk of coronary artery disease. Arterioscler. Thromb. Vasc. Biol., 1997, vol. 17, pp. 1067–1073.Shi Y., NiculescuК., Wang D. et al. Increased NAD(P)H Ox-idase end Reactive Oxygen Species in Coronary Arteries Af-ter Balloon Injury // Arterioscler. Thromb. Vasc. Biol. 2001. V. 21. P. 739–745.Shi Y., Niculescu К., Wang D. et al. Increased NAD(P)H Oxidase end Reactive Oxygen Species in Coronary Arteries After Balloon Injury. Arterioscler. Thromb. Vasc. Biol., 2001, vol. 21, pp. 739–745.Suzuki T., Okumura K., Sone T. et al. The Glu298Asp poly-morphism in endothelial nitric oxide synthase gene is associ-ated with coronary in-stent restenosis // Int. J. Cardiol. 2002. V. 6. P. 71–76.Suzuki T., Okumura K., Sone T. et al. The Glu298Asp polymorphism in endothelial nitric oxide synthase gene is associated with coronary in-stent restenosis. Int. J. Cardiol., 2002, vol. 6, pp. 71–76.Toshisuke M. Heme Oxygenase and Atherosclerosis // Arterioscler. Thromb. Vasc. Biol. 2005. V. 25. P. 1786–1795.Toshisuke M. Heme Oxygenase and Atherosclerosis. Arterioscler. Thromb. Vasc. Biol., 2005, vol. 25, pp. 1786–1795.Trompet S., Jukema J.W., Sampietro M.L., Houwing-Duistermaat J.J. et al. Systematic Testing of Literature Re-ported Genetic Variation Associated with Coronary Resteno-sis: Results of the GENDER Study // Plos One. 2012. V. 7 (8).Trompet S., Jukema J. W., Sampietro M. L., HouwingDuistermaat J.J. et al. Systematic Testing of Literature Reported Genetic Variation Associated with Coronary Restenosis: Results of the GENDER Study. Plos One, 2012, vol. 7 (8).van Tiel C.M., Bonta P.I., Rittersma S.Z., Beijk M.A. et al. p27kip1– 838C>A Single Nucleotide Polymorphism Is As-sociated With Restenosis Risk After Coronary Stenting and Modulates p27kip1 Promoter Activity // Circulation. 2009. V. 120 (8). P. 669–676.van Tiel C.M., Bonta P.I., Rittersma S.Z., Beijk M.A. et al. p27kip1– 838C>A Single Nucleotide Polymorphism Is Associated With Restenosis Risk After Coronary Stenting and Modulates p27kip1 Promoter Activity. Circulation, 2009, vol. 120 (8), pp. 669–676.Verschuren J.J., Trompet S., Postmus I., Sampietro M.L. et al. Systematic testing of literature reported genetic variation associated with coronary restenosis: results of the GENDER Study // PLoS One. 2012. V. 8. P. 1–8.Verschuren J.J., Trompet S., Postmus I., Sampietro M.L. et al. Systematic testing of literature reported genetic variation associated with coronary restenosis: results of the GENDER Study. PLoS One, 2012, vol. 8, pp. 1–8.Volzke H., Grimm R., Robinson D.M. et al. Candidate genetic markers and the risk of restenosis after coronary angioplasty // Clin. Sci. (Lond). 2004. V. 106. P. 35–42.Volzke H., Grimm R., Robinson D.M. et al. Candidate genetic markers and the risk of restenosis after coronary angioplasty. Clin. Sci. (Lond), 2004, vol. 106, pp. 35–42.Volzke H., Hertwig S., Rettig R., Motz W. The angiotensino-gen gene 235T variant is associated with an increased risk of restenosis after percutaneous transluminal coronary angio-plasty // Clin. Sci. 2000. V. 99 (1). P. 19–25.Volzke H., Hertwig S., Rettig R., Motz W. The angiotensinogen gene 235T variant is associated with an increased risk of restenosis after percutaneous transluminal coronary angioplasty. Clin. Sci., 2000, vol. 99. (1), pp. 19–25.Wang S., Dai Y., Chen L., Dong Z. et al. Genetic polymor-phism of angiotensin converting enzyme and risk of coronary restenosis after percutaneous transluminal coronary an-gioplasties: evidence from 33 cohort studies // PLoS One. 2013. V. 8. P. 1.Wang S., Dai Y., Chen L., Dong Z., et al. Genetic polymorphism of angiotensin converting enzyme and risk of coronary restenosis after percutaneous transluminal coronary angioplasties: evidence from 33 cohort studies. PLoS One, 2013, vol. 8, pp. 1.Ward M.R., Jeremias A., Hibi K. et al. The influence of plaque orientation (pericardial or myocardial) on coronary arterial remodeling // Atherosclerosis. 2001. V. 154 (1). P. 179–183.Ward M.R., Jeremias A., Hibi K. et al. The influence of plaque orientation (pericardial or myocardial) on coronary arterial remodeling. Atherosclerosis, 2001, vol. 154 (1), pp. 179–183.Wijpkema J.S., Van Haelst P.L., Monraats P.S., Bruinenberg M. et al. Restenosis after percutaneous coronary intervention is associated with the angiotensin-II type-1 receptor 1166A/C polymorphism but not with polymorphisms of angiotensin-converting enzyme, angiotensin-II receptor, angiotensinogen or heme oxygenase-1 // Pharmacogenet Genomics. 2006. V. 16 (5). P. 331–337.Wijpkema J.S., Van Haelst P.L., Monraats P.S., Bruinenberg M. et al. Restenosis after percutaneous coronary intervention is associated with the angiotensin-II type-1 receptor 1166A/C polymorphism but not with polymorphisms of angiotensin-converting enzyme, angiotensin-II receptor, angiotensinogen or heme oxygenase-1. Pharmacogenet Genomics, 2006, vol. 16. (5), pp. 331–337.Yu G.I., Cho H.C., Cho Y.K., Park H.S. et al. Association of promoter region single nucleotide polymorphisms at positions -819C/T and -592C/A of interleukin 10 gene with ischemic heart disease // Inflamm. Res. 2012. V. 61 (8). P. 899–905.Yu G.I., Cho H.C., Cho Y.K., Park H.S. et al. Association of promoter region single nucleotide polymorphisms at positions -819C/T and -592C/A of interleukin 10 gene with ischemic heart disease. Inflamm. Res., 2012, vol. 61. (8), pp. 899–905.Zee RY., Fernandez-Ortiz A., Macaya C., Pintor E. et al. IL-1 cluster genes and occurrence of post-percutaneous transluminal coronary angioplasty restenosis: a prospective, angiography-based evaluation // Atherosclerosis. 2003. V. 17. (2). P. 259–264.Zee RY., Fernandez-Ortiz A., Macaya C., Pintor E. et al. IL-1 cluster genes and occurrence of post-percutaneous transluminal coronary angioplasty restenosis: a prospective, angiography-based evaluation. Atherosclerosis, 2003, vol. 17 (2), pp. 259–264.

The authors declare that there are no conflicts of interest present.