ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2010-1-76-83ssmu-1535Research ArticleОБЗОР ЛИТЕРАТУРЫLITERATURE REVIEWРоль цитокинов в патогенезе аутоиммунного диабета, вопросы иммуноинтервенцииThe role of cytokines in the pathogenesis of autoimmune diabetes, immune intervention issuesКравецЕ. Б.KravetsYe. B.

д-р мед. наук, профессор, зав. кафедрой эндокринологии и диабетологии 

СапринаТ. В.SaprinaT. V.

канд. мед. наук, доцент кафедры эндокринологии и диабетологии

ЛазаренкоФ. Э.LazarenkoF. E.

Лазаренко Феликс Эдуардович, аспирант кафедры эндокринологии и диабетологии 

тел. (382-2) 42-79-80, 8-913-851-7144, e-mail: eliksi@sibmail.com

eliksi@yandex.ruПрохоренкоТ. С.ProkhorenkoT. S.

аспирант кафедры фундаментальных основ клинической медицины

РязанцеваН. В.RyazantsevaN. V.

д-р мед. наук, профессор, зав. кафедрой фундаментальных основ клинической медицины

Сибирский государственный медицинский университетРоссия201028022010917683Copyright © Кравец Е.Б., Саприна Т.В., Лазаренко Ф.Э., Прохоренко Т.С., Рязанцева Н.В., 20102010Кравец Е.Б., Саприна Т.В., Лазаренко Ф.Э., Прохоренко Т.С., Рязанцева Н.В.Kravets Y.B., Saprina T.V., Lazarenko F.E., Prokhorenko T.S., Ryazantseva N.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/1535

Рассмотрена роль цитокинов в патогенезе аутоиммунного сахарного диабета, включая латентный аутоиммунный диабет взрослых. Обсуждаются терапевтические подходы, направленные на предупреждение снижения секреции эндогенного инсулина. Приведен обзор клинических испытаний иммуносупрессивных средств и модуляторов иммунологической толерантности при аутоиммунном сахарном диабете (типа 1А).

The review devotes to studying the role of cytokines in development of autoimmune diabetes mellitus, latent autoimmune diabetes in adults included. Therapeutic approaches to prevent the loss of endogenous insulin secretion are discussed. There is review of clinical trials of immunosuppressive agents and modulators of immune tolerance in autoimmune diabetes mellitus.

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The authors declare that there are no conflicts of interest present.