ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2015-3-49-62ssmu-171Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESЭТИОПАТОГЕНЕЗ И АНАЛИЗ АНТИБИОТИКОТЕРАПИИ ПРИ СИНДРОМЕ ИЗБЫТОЧНОГО БАКТЕРИАЛЬНОГО РОСТА В ТОНКОЙ КИШКЕTHE ETHIOPATOGENESIS AND THE ANALYSIS OF AN ANTIBIOTIC TREATMENT OF A SMALL INTESTINE BACTERIAL OVERGROWTH SYNDROMEМартыновВ. Л.MartynovV. L.

Мартынов Владимир Леонидович, доктор медицинских наук, доцент, профессор кафедры «Хирургические болезни»

xirurg.net@yandex.ruХайрдиновА. Х.KhairdinovA. Kh.

Хайрдинов Артур Хасянович, врач-хирург хирургического отделения

xirurg.net@yandex.ruГородская клиническая больница № 12, Нижний НовгородРоссияCity Clinical Hospital № 12 of Nizhny Novgorod, Nizhny NovgorodRussian Federation2015280620151434962Copyright © Мартынов В.Л., Хайрдинов А.Х., 20152015Мартынов В.Л., Хайрдинов А.Х.Martynov V.L., Khairdinov A.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/171

Представлен анализ современных подходов к лечению синдрома избыточного бактериального роста в тонкой кишке (СИБР). В настоящее время СИБР является одной из важнейших проблем в гастроэнтерологии. Избыточный бактериальный рост выступает одновременно причиной и следствием многих заболеваний пищеварительной системы и внепищеварительных проявлений. Многие исследования свидетельствуют о широкой распространенности СИБР среди пациентов гастроэнтерологического профиля, однако патогенез заболевания на сегодняшний день изучен недостаточно. Тем не менее имеющиеся данные научных исследований позволяют критически относиться к предлагаемым способам диагностики и лечения.В обзорной статье приводятся сведения о физиологии микрофлоры пищеварительного тракта здорового человека. Рассматриваются механизмы противомикробной резистентности микробиоты кишечника. Выявляется связь между антибиотикассоциированной дегенерацией нормальной флоры человека и избыточным бактериальным ростом в тонкой кишке. В ходе анализа антибиотикотерапии СИБР обнаружена ее низкая эффективность, а также возможные пути хронизации и частые рецидивы болезни. Признавая многофакторность и сложность патогенеза СИБР, авторы предлагают использовать этиопатогенетические подходы для решения проблемы СИБР.

Article is attempt of the critical analysis of modern approaches to treatment of a small intestine bacterial overgrowth syndrome (SIBO). SIBO now is one of the major problems in gastroenterology. At the same time, the bacterial overgrowth is cause and consequence of many diseases of digestive system and extradigestive manifestations. Many researches testify to prevalence of SIBO in patients with digestive diseases. However, pathogenesis of a disease is studied insufficiently today. Nevertheless, the available data of scientific researches allow to belong to the offered ways of diagnostics and treatment critically.Data on physiology of microbiota of the digestive tract of the healthy person are provided in a review. Mechanisms of antimicrobic resistance of a microbiota of intestines are considered. Interrelations between an antibiotikassociated degeneration of normal flora and bacterial overgrowth are presented. The analysis of an antibiotiktherapi of SIBO indicates low efficiency and also possible ways became chronicle diseaseand frequent recurrence of an illness. The multiple-factors and complexity of pathogenesis of SIBO are leaded authors to a conclusion to use ethiopathogenesis approaches for solution of SIBO.

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The authors declare that there are no conflicts of interest present.