<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ssmu</journal-id><journal-title-group><journal-title xml:lang="ru">Бюллетень сибирской медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of Siberian Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-0363</issn><issn pub-type="epub">1819-3684</issn><publisher><publisher-name>Siberian State Medical University, the Ministry of Healthcare of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20538/1682-0363-2009-1-64-70</article-id><article-id custom-type="elpub" pub-id-type="custom">ssmu-1746</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАУЧНЫЙ И УЧЕБНЫЙ ПРОЦЕСС: МЕТОДИЧЕСКИЙ СЕМИНАР</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SCIENTIFIC AND STUDYING PROCESS: METHODIC SEMINAR</subject></subj-group></article-categories><title-group><article-title>Роль апоптоза в развитии аутоиммунных заболеваний щитовидной железы</article-title><trans-title-group xml:lang="en"><trans-title>The role of apoptosis in development of autoimmune thyroid diseases</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Недосекова</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nedosekova</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант кафедры патофизиологии</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Уразова</surname><given-names>О. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Urasova</surname><given-names>O. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д р мед наук профессор кафедры патофизиологии</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кравец</surname><given-names>Е. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Kravets</surname><given-names>Ye. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д р мед наук профессор зав кафедрой эндокринологии и диабетологии</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чайковский</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Chaikovsky</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>студент VI курса педиатрического факультета</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Сибирский государственный медицинский университет</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2009</year></pub-date><pub-date pub-type="epub"><day>28</day><month>02</month><year>2009</year></pub-date><volume>8</volume><issue>1</issue><fpage>64</fpage><lpage>70</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Недосекова Ю.В., Уразова О.И., Кравец Е.Б., Чайковский А.В., 2009</copyright-statement><copyright-year>2009</copyright-year><copyright-holder xml:lang="ru">Недосекова Ю.В., Уразова О.И., Кравец Е.Б., Чайковский А.В.</copyright-holder><copyright-holder xml:lang="en">Nedosekova Y.V., Urasova O.I., Kravets Y.B., Chaikovsky A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://bulletin.ssmu.ru/jour/article/view/1746">https://bulletin.ssmu.ru/jour/article/view/1746</self-uri><abstract/><trans-abstract xml:lang="en"><p>In the review representations about a role apoptosis by autoimmune thyroid diseases, such as Graves' disease and Hashimoto's thyroiditis, the basic pathogenetic links immunological abnormalities at the these diseases have been discussed. At has been demonstrated changes in a thyroid gland, and also changes endocellular pro- and anti-apoptotic factors are shown at Hashimoto's thyroiditis and Graves' disease.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>апоптоз</kwd><kwd>болезнь Грейвса</kwd><kwd>болезнь Хасимото</kwd></kwd-group><kwd-group xml:lang="en"><kwd>apoptosis</kwd><kwd>Graves' disease</kwd><kwd>Hashimoto's thyroiditis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Абрамова Н.А., Фадеев В.В. и др. Консервативное лечение болезни Грейвса: принципы, маркеры рецидива и ремиссии//Проблемы эндокринологии. 2005. Т. 51. № 6. С. 44-49</mixed-citation><mixed-citation xml:lang="en">Абрамова Н.А., Фадеев В.В. и др. Консервативное лечение болезни Грейвса: принципы, маркеры рецидива и ремиссии//Проблемы эндокринологии. 2005. Т. 51. № 6. С. 44-49</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Белушкина Н.Н., Северин С.Е. Молекулярные основы патологии апоптоза//Арх. патологии. 2001. № 1. С. 51-60</mixed-citation><mixed-citation xml:lang="en">Белушкина Н.Н., Северин С.Е. Молекулярные основы патологии апоптоза//Арх. патологии. 2001. № 1. С. 51-60</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Кандрор В.И., Крайнова С.И., Крюкова И.В. и др. Антитиреоидные антитела и аутоиммунные заболевания//Проблемы эндокринологии. 1997. № 3. С. 25-30</mixed-citation><mixed-citation xml:lang="en">Кандрор В.И., Крайнова С.И., Крюкова И.В. и др. Антитиреоидные антитела и аутоиммунные заболевания//Проблемы эндокринологии. 1997. № 3. С. 25-30</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Крайнова С.И., Крюкова И.В., Мкртумова Н.А. и др. Стимуляция роста «нормальных» тиреоцитов лимфоцитами, инфильтрирующими ткань диффузного токсического зоба//Проблемы эндокринологии. 2001. № 3. С. 3-5.</mixed-citation><mixed-citation xml:lang="en">Крайнова С.И., Крюкова И.В., Мкртумова Н.А. и др. Стимуляция роста «нормальных» тиреоцитов лимфоцитами, инфильтрирующими ткань диффузного токсического зоба//Проблемы эндокринологии. 2001. № 3. С. 3-5.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Пивень Н.В., Новиков В.В., Лухверчик Л.Н., Кузьменко-ва Е.И. Иммуноферментный анализ FAS-рецептора (CD95) у лиц с патологией щитовидной железы//Иммунопатология, аллергология, инфектология. 2001. № 3. С. 15-20</mixed-citation><mixed-citation xml:lang="en">Пивень Н.В., Новиков В.В., Лухверчик Л.Н., Кузьменко-ва Е.И. Иммуноферментный анализ FAS-рецептора (CD95) у лиц с патологией щитовидной железы//Иммунопатология, аллергология, инфектология. 2001. № 3. С. 15-20</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Самуилов В.Д., Алексин А.В., Лагунова Е.М. Программированная клеточная гибель//Биохимия. 2000. Т. 65. № 8. С. 1029-1046</mixed-citation><mixed-citation xml:lang="en">Самуилов В.Д., Алексин А.В., Лагунова Е.М. Программированная клеточная гибель//Биохимия. 2000. Т. 65. № 8. С. 1029-1046</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ярилин А.А. Природа феномена и его роль в целостном организме//Патолог. физиология. 1998. № 2. С. 38-48</mixed-citation><mixed-citation xml:lang="en">Ярилин А.А. Природа феномена и его роль в целостном организме//Патолог. физиология. 1998. № 2. С. 38-48</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ярилин А.А. Апоптоз и его место в иммунных процессах//Иммунология. 1996. № 6. С. 10-22</mixed-citation><mixed-citation xml:lang="en">Ярилин А.А. Апоптоз и его место в иммунных процессах//Иммунология. 1996. № 6. С. 10-22</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Aravid L., Dixit V.M., Koom E.V. The domains of death: evolution of the apoptosis machinery//Trends Biochem. Sci. 1999. V. 24. P. 47-53</mixed-citation><mixed-citation xml:lang="en">Aravid L., Dixit V.M., Koom E.V. The domains of death: evolution of the apoptosis machinery//Trends Biochem. Sci. 1999. V. 24. P. 47-53</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Arends M.J., Wyllie A.H. Mechanism and role in patology//Inlern. Rev. Exp. Pathol. 1991. V. 32. P. 223-254</mixed-citation><mixed-citation xml:lang="en">Arends M.J., Wyllie A.H. Mechanism and role in patology//Inlern. Rev. Exp. Pathol. 1991. V. 32. P. 223-254</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Arscott P.L., Knapp J., Rymaszewski M., Bartron J.L. et al. Fas (APO-1, CD95)-mediated apoptosis in thyroid cells is regulated by a labile protein inhibitor // Endocrinology. 1997. V. 138. P. 5019—5027.</mixed-citation><mixed-citation xml:lang="en">Arscott P.L., Knapp J., Rymaszewski M., Bartron J.L. et al. Fas (APO-1, CD95)-mediated apoptosis in thyroid cells is regulated by a labile protein inhibitor // Endocrinology. 1997. V. 138. P. 5019—5027.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Bellgrau D., Gold D., Selawry H. et al. A role for CD95 ligand in preventing graft rejection // Nature. 1995. V. 377. P. 630— 632.</mixed-citation><mixed-citation xml:lang="en">Bellgrau D., Gold D., Selawry H. et al. A role for CD95 ligand in preventing graft rejection // Nature. 1995. V. 377. P. 630— 632.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Bennett M.R. Apoptosis in the cardiovascular system Heart // 2002. V. 87. 5. P. 480—487.</mixed-citation><mixed-citation xml:lang="en">Bennett M.R. Apoptosis in the cardiovascular system Heart // 2002. V. 87. 5. P. 480—487.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Bermann M., Magee M., Koenig R.J. Differential autoantibody responses to thyroid peroxidase in patients with Grave’s desease and Hashimoto thyroiditis // J. of Clinical Endocrinology and Metabolism. 1993. V. 77. P. 1098—1101.</mixed-citation><mixed-citation xml:lang="en">Bermann M., Magee M., Koenig R.J. Differential autoantibody responses to thyroid peroxidase in patients with Grave’s desease and Hashimoto thyroiditis // J. of Clinical Endocrinology and Metabolism. 1993. V. 77. P. 1098—1101.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Boice L.H., Minn A.J., June C.H. et al. Growth factors can enhance lymphocyte survival without committing the cell to undergo cell division // Proc. Natl. Acad. Sci. USA. 1995. V. 92. P. 1223—1232.</mixed-citation><mixed-citation xml:lang="en">Boice L.H., Minn A.J., June C.H. et al. Growth factors can enhance lymphocyte survival without committing the cell to undergo cell division // Proc. Natl. Acad. Sci. USA. 1995. V. 92. P. 1223—1232.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Combadiere B., Reise Sousa C., Trageser C. et al. Differential TCR signaling regulates apoptosis and immunopathology during antigen responses in vivo // Immunity. 1998. V. 9. P. 305—313.</mixed-citation><mixed-citation xml:lang="en">Combadiere B., Reise Sousa C., Trageser C. et al. Differential TCR signaling regulates apoptosis and immunopathology during antigen responses in vivo // Immunity. 1998. V. 9. P. 305—313.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">De Flora A., Franco L., Guida L., Bruzzone S. et al. Ectocellular CD38-catalyzed synthesis and intracellular Ca2+-mobilizing activity of cyclic ADP-ribose // Cell Biochem. Biophys. 1998. V. 28. P. 45—62.</mixed-citation><mixed-citation xml:lang="en">De Flora A., Franco L., Guida L., Bruzzone S. et al. Ectocellular CD38-catalyzed synthesis and intracellular Ca2+-mobilizing activity of cyclic ADP-ribose // Cell Biochem. Biophys. 1998. V. 28. P. 45—62.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">De Maria R., Testi R. Fas-FasL interactions: a common pathogenetic mechanism in organ-specific autoimmunity // Immunol. Today 1998. V. 19. P. 121—125.</mixed-citation><mixed-citation xml:lang="en">De Maria R., Testi R. Fas-FasL interactions: a common pathogenetic mechanism in organ-specific autoimmunity // Immunol. Today 1998. V. 19. P. 121—125.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Fry T.J., Connick E., Falloon J. et al. A potential role for interleukin-7 in T-cell homeostasis // Blood. 2001. V. 97. P. 2983— 2990.</mixed-citation><mixed-citation xml:lang="en">Fry T.J., Connick E., Falloon J. et al. A potential role for interleukin-7 in T-cell homeostasis // Blood. 2001. V. 97. P. 2983— 2990.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Giordano C., Stassi G., De Maria R. et al. Potentional involment of Fas and its ligand in the pathogenesis of Hashimoto’s thyroiditis // Science. 1997. V. 275. P. 960—963.</mixed-citation><mixed-citation xml:lang="en">Giordano C., Stassi G., De Maria R. et al. Potentional involment of Fas and its ligand in the pathogenesis of Hashimoto’s thyroiditis // Science. 1997. V. 275. P. 960—963.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Griffith T.S., Brunner T., Fletcher S.M. et al. Fas ligand-induced apoptosis as a mechanism of immune privilege // Science. 1995. V. 270. P. 1189—1192.</mixed-citation><mixed-citation xml:lang="en">Griffith T.S., Brunner T., Fletcher S.M. et al. Fas ligand-induced apoptosis as a mechanism of immune privilege // Science. 1995. V. 270. P. 1189—1192.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Hammond L.J., Lowdell M.W., Cerrano P.G. et al. Analysis of apoptosis in relation to tissue destruction associated with Hashimoto’s autoimmune thyroiditis // J. of Pathology. 1997. V. 182. P. 138—144.</mixed-citation><mixed-citation xml:lang="en">Hammond L.J., Lowdell M.W., Cerrano P.G. et al. Analysis of apoptosis in relation to tissue destruction associated with Hashimoto’s autoimmune thyroiditis // J. of Pathology. 1997. V. 182. P. 138—144.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Hiromatsu Y., Bednarczuk T., Soyejima E. et al. Increased serum soluble Fas in patients with Graves’ disease // Thyroid. 1999. V. 9. P. 341—345.</mixed-citation><mixed-citation xml:lang="en">Hiromatsu Y., Bednarczuk T., Soyejima E. et al. Increased serum soluble Fas in patients with Graves’ disease // Thyroid. 1999. V. 9. P. 341—345.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Hiromatsu Y., Hoshino T., Yagita H. et al. Functional Fas ligand expression in thyrocytes from patients with Graves’ disease // J. Clinical Endocrinology and Metabolism. 1999. Vol. 84. P. 2896—2902.</mixed-citation><mixed-citation xml:lang="en">Hiromatsu Y., Hoshino T., Yagita H. et al. Functional Fas ligand expression in thyrocytes from patients with Graves’ disease // J. Clinical Endocrinology and Metabolism. 1999. Vol. 84. P. 2896—2902.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Ju S.T. et al. Fas (CD95)/FasL interactions required for programmed cell death after activation // Nature. 1995. V. 373. P. 444.</mixed-citation><mixed-citation xml:lang="en">Ju S.T. et al. Fas (CD95)/FasL interactions required for programmed cell death after activation // Nature. 1995. V. 373. P. 444.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Kalkeri G., Khalap N., Garry R.F. et al. Hepatits С virus protein expression induced apoptosis in HepG2 cells // Virology. 2001. V. 282. 1. P. 26—37. №</mixed-citation><mixed-citation xml:lang="en">Kalkeri G., Khalap N., Garry R.F. et al. Hepatits С virus protein expression induced apoptosis in HepG2 cells // Virology. 2001. V. 282. 1. P. 26—37. №</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Kawakami A., Eguchi K., Matsuoka N. et al. Thyroid-stimulating hormone inhibits Fas antigen-mediated apoptosis of human thyrocytes in vitro // Endocrinology. 1996. V. 137. P. 3163—3169.</mixed-citation><mixed-citation xml:lang="en">Kawakami A., Eguchi K., Matsuoka N. et al. Thyroid-stimulating hormone inhibits Fas antigen-mediated apoptosis of human thyrocytes in vitro // Endocrinology. 1996. V. 137. P. 3163—3169.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Kidd V.J. Proteolytic activities that mediate apoptosis // Annu. Rev. Physiol. 1998. V. 60. P. 533—573.</mixed-citation><mixed-citation xml:lang="en">Kidd V.J. Proteolytic activities that mediate apoptosis // Annu. Rev. Physiol. 1998. V. 60. P. 533—573.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Krammer P.H. CD95's deadly mission in the immune system // Nature. 2000. V. 407. P. 789—795.</mixed-citation><mixed-citation xml:lang="en">Krammer P.H. CD95's deadly mission in the immune system // Nature. 2000. V. 407. P. 789—795.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Lenardo M., Chan F.K.-M., Hornug F. et al. Nature T-lymphocyte apoptosis-immune regulation in a dynamic and unpredictable antigenic environment // Annu. Rev. Immunol. 1999. V. 17. P. 221— 253.</mixed-citation><mixed-citation xml:lang="en">Lenardo M., Chan F.K.-M., Hornug F. et al. Nature T-lymphocyte apoptosis-immune regulation in a dynamic and unpredictable antigenic environment // Annu. Rev. Immunol. 1999. V. 17. P. 221— 253.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Lord J.D., McIntoch B.C., Greeberg Ph.D., Nelson B.H. The IL-2 receptor promotes lymphocyte proliferation and induction of the c-myc, bcl-2, and bcl-x genes through the trans-activation domain of Stat5 // J. Immynol. 2000. V. 164. P. 2533—2541.</mixed-citation><mixed-citation xml:lang="en">Lord J.D., McIntoch B.C., Greeberg Ph.D., Nelson B.H. The IL-2 receptor promotes lymphocyte proliferation and induction of the c-myc, bcl-2, and bcl-x genes through the trans-activation domain of Stat5 // J. Immynol. 2000. V. 164. P. 2533—2541.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Mei X.W. et al. Induction and detection of apoptosis in human periphery blood T-cells // J. Immunological methods. 1997. V. 206. P. 153 —162.</mixed-citation><mixed-citation xml:lang="en">Mei X.W. et al. Induction and detection of apoptosis in human periphery blood T-cells // J. Immunological methods. 1997. V. 206. P. 153 —162.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Mitsiades N., Poulaki V., Kotoula V. et al. Fas/Fas ligand up-regulation and Bcl-2 down-regulation may be significant in the pathogenesis of Hashimoto’s thyroiditis // J. Clin. Endocrinology and Metabolism. 1998. V. 83. P. 2199—2203.</mixed-citation><mixed-citation xml:lang="en">Mitsiades N., Poulaki V., Kotoula V. et al. Fas/Fas ligand up-regulation and Bcl-2 down-regulation may be significant in the pathogenesis of Hashimoto’s thyroiditis // J. Clin. Endocrinology and Metabolism. 1998. V. 83. P. 2199—2203.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Mountz J.D., Wu J., Cheng J., Zhou T. Autoimmune disease: A problem of defective apoptosis // Arthritis Rheum. 1994. V. 37. P. 1415 —1420.</mixed-citation><mixed-citation xml:lang="en">Mountz J.D., Wu J., Cheng J., Zhou T. Autoimmune disease: A problem of defective apoptosis // Arthritis Rheum. 1994. V. 37. P. 1415 —1420.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Mountz J.D., Zhang H.G., Hsu H.C. et al. Apoptosis and cell death in the endocrine system // Recent Progress in Hormone Research. 1999. V. 54. P. 235—269.</mixed-citation><mixed-citation xml:lang="en">Mountz J.D., Zhang H.G., Hsu H.C. et al. Apoptosis and cell death in the endocrine system // Recent Progress in Hormone Research. 1999. V. 54. P. 235—269.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Nishimoto I., Okamoto Т., Gramorella U., Iwatsubo T. Apoptosis in neurodegenerative disease // Adv. Pharmacol. 1997. V. 41. P. 337—369.</mixed-citation><mixed-citation xml:lang="en">Nishimoto I., Okamoto Т., Gramorella U., Iwatsubo T. Apoptosis in neurodegenerative disease // Adv. Pharmacol. 1997. V. 41. P. 337—369.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Pan H., Yin C., Dyke T. Apoptosis and cancer mechanisms // Cancer Surveys. 1997. V. 29. P. 305—327.</mixed-citation><mixed-citation xml:lang="en">Pan H., Yin C., Dyke T. Apoptosis and cancer mechanisms // Cancer Surveys. 1997. V. 29. P. 305—327.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Palazzo F.F., Ammond L.J., Goode A.W., Mirakian R. Death of the autoimmune thyrocyte: is it pushed or does it jump? // Thyroid. 2000. V. 10. P. 561—572.</mixed-citation><mixed-citation xml:lang="en">Palazzo F.F., Ammond L.J., Goode A.W., Mirakian R. Death of the autoimmune thyrocyte: is it pushed or does it jump? // Thyroid. 2000. V. 10. P. 561—572.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Paolieri F., Salmaso C., Battifora M. et al. Possible pathogenetic relevance of interleukin-1 beta in «destructive» organ-specific autoimmune disease (Hashimoto's thyroiditis) // Ann. N.Y. Acad. Sci. 1999. V. 22. 876. P. 221—228.</mixed-citation><mixed-citation xml:lang="en">Paolieri F., Salmaso C., Battifora M. et al. Possible pathogenetic relevance of interleukin-1 beta in «destructive» organ-specific autoimmune disease (Hashimoto's thyroiditis) // Ann. N.Y. Acad. Sci. 1999. V. 22. 876. P. 221—228.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Schober S.L., Kuo C.T., Schluns K.S. et al. Expression of the transcription factor lung Krüppel-like factor is regulated by cytokines and correlates with survival of memory T cells in vitro and in vivo // J. Immunol. 1999. V. 163. P. 3662—3667.</mixed-citation><mixed-citation xml:lang="en">Schober S.L., Kuo C.T., Schluns K.S. et al. Expression of the transcription factor lung Krüppel-like factor is regulated by cytokines and correlates with survival of memory T cells in vitro and in vivo // J. Immunol. 1999. V. 163. P. 3662—3667.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Sheikh M.S., Fornace A.J. Death and decoy receptors and p53- mediated apoptosis // Leukemia. 2000. V. 14. P. 1509—1513.</mixed-citation><mixed-citation xml:lang="en">Sheikh M.S., Fornace A.J. Death and decoy receptors and p53- mediated apoptosis // Leukemia. 2000. V. 14. P. 1509—1513.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Stassi G., Di Liberto D., Todaro M. et al. Control of target cell survival in thyroid autoimmunity by T helper cytokines via regulation of apoptotic proteins // Nat. Immunol. 2000. V. 1. P. 483—488.</mixed-citation><mixed-citation xml:lang="en">Stassi G., Di Liberto D., Todaro M. et al. Control of target cell survival in thyroid autoimmunity by T helper cytokines via regulation of apoptotic proteins // Nat. Immunol. 2000. V. 1. P. 483—488.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Tanaka M., Suda Т., Haze K. et al. Fas ligand in human serum // Nat. Med. 1996. V. 2. P. 317.</mixed-citation><mixed-citation xml:lang="en">Tanaka M., Suda Т., Haze K. et al. Fas ligand in human serum // Nat. Med. 1996. V. 2. P. 317.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Tanimoto C., Hirakawa S., Kawasaki H. et al. Apoptosis in thyroid diseases: a histochemical study // Endocrine Journal. 1995. V. 42. P. 193—201.</mixed-citation><mixed-citation xml:lang="en">Tanimoto C., Hirakawa S., Kawasaki H. et al. Apoptosis in thyroid diseases: a histochemical study // Endocrine Journal. 1995. V. 42. P. 193—201.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Weetman A.P., McGregor A.M. Autoimmune thyroid disease: further developments in our understanding // Endocrine Reviews. 1994. V. 15. P. 788—830.</mixed-citation><mixed-citation xml:lang="en">Weetman A.P., McGregor A.M. Autoimmune thyroid disease: further developments in our understanding // Endocrine Reviews. 1994. V. 15. P. 788—830.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Weetman A.P., McGregor A.M. Antigen presentation in the pathogenesis of autoimmune endocrine disease // J. Autoimmun. 1995. V. 3. P. 305—312.</mixed-citation><mixed-citation xml:lang="en">Weetman A.P., McGregor A.M. Antigen presentation in the pathogenesis of autoimmune endocrine disease // J. Autoimmun. 1995. V. 3. P. 305—312.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Weetman A.P. Graves' disease // N. Engl. J. Med. 2000. V. 343. P. 1236—1248.</mixed-citation><mixed-citation xml:lang="en">Weetman A.P. Graves' disease // N. Engl. J. Med. 2000. V. 343. P. 1236—1248.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Yanagisawa J., Takahashi M., Kanki H. et al. The molecular interaction of Fas and FAP-1: a tripeptide blocker of human Fas interaction with FAP-1 promotes Fas-induced apoptosis // J. Biol. Chem. 1997. V. 272. P. 8539—8545.</mixed-citation><mixed-citation xml:lang="en">Yanagisawa J., Takahashi M., Kanki H. et al. The molecular interaction of Fas and FAP-1: a tripeptide blocker of human Fas interaction with FAP-1 promotes Fas-induced apoptosis // J. Biol. Chem. 1997. V. 272. P. 8539—8545.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
