ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2014-6-165-173ssmu-175Research ArticleПРОБЛЕМЫ ФИЗИОЛОГИИPROBLEMS OF PHYSIOLOGYНАТРИЙ-КАЛИЙ-ХЛОР-КОТРАНСПОРТ В РЕГУЛЯЦИИ МИОГЕННОГО ТОНУСА СОСУДОВSODIUM-POTASSIUM-CHLORIDE COTRANSPORT IN THE REGULATION OF VASCULAR MYOGENIC TONEОрловС. Н.OrlovS. N.

Орлов Сергей Николаевич – доктор биологических наук, профессор биологического факультета

sergeinorlov@yandex.ruКольцоваС. В.KoltsovaS. V.

Кольцова Светлана Викторовна – кандидат медицинских наук, биологический факультет

sergeinorlov@yandex.ruАнфиногеноваЯ. Д.AnfinogenovaYa. D.

Анфиногенова Яна Джоновна – доктор медицинских наук 

sergeinorlov@yandex.ruКапилевичЛ. В.KapilevichL. V.

Капилевич Леонид Владимирович – доктор медицинских наук, профессор,

sergeinorlov@yandex.ruГусаковаС. В.GusakovaS. N.

Гусакова Светлана Валерьевна– доктор медицинских наук, доцент, зав. кафедрой биофизики и функциональной диагностики 

sergeinorlov@yandex.ruСмаглийЛ. В.SmagliyL. V.

Смаглий Людмила Владимировна – кандидат медицинских наук

sergeinorlov@yandex.ruБаскаковМ. Б.BaskakovM. B.

Баскаков Михаил Борисович – доктор медицинских наук, профессор

sergeinorlov@yandex.ruМедведевМ. А.MedvedevM. A.

Медведев Михаил Андреевич – заслуженный деятель науки РФ, доктор медицинских наук, профессор, академик РАН, зав. кафедрой нормальной физиологии

sergeinorlov@yandex.ruМосковский государственный университет им. М.В. Ломоносова, Москва; Национальный исследовательский Томский государственный университет, ТомскРоссияM.V. Lomonosov Moscow State University, Moscow; National Research Tomsk State University, TomskRussian FederationМосковский государственный университет им. М.В. Ломоносова, МоскваРоссияM.V. Lomonosov Moscow State University, MoscowRussian FederationСибирский государственный медицинский университет, ТомскРоссияSiberian Medical UniversityRussian FederationНациональный исследовательский Томский государственный университет, Томск; Сибирский государственный медицинский университет, ТомскРоссияNational Research Tomsk State University, Tomsk; Siberian Medical UniversityRussian Federation201428122014136165173Copyright © Орлов С.Н., Кольцова С.В., Анфиногенова Я.Д., Капилевич Л.В., Гусакова С.В., Смаглий Л.В., Баскаков М.Б., Медведев М.А., 20142014Орлов С.Н., Кольцова С.В., Анфиногенова Я.Д., Капилевич Л.В., Гусакова С.В., Смаглий Л.В., Баскаков М.Б., Медведев М.А.Orlov S.N., Koltsova S.V., Anfinogenova Y.D., Kapilevich L.V., Gusakova S.N., Smagliy L.V., Baskakov M.B., Medvedev M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/175Na+K+2Cl–-котранспортартериальная гипертензияNa+K+2Cl– cotransportarterial hypertensionReferencesHediger M.A., Romero M.F., Peng J.-B., Rolfs A., Ta-kanaga H., Bruford E.A. The ABCs of solute carriers: physiological, pathophysiological and therapeutic implications of human membrane transport protein // Pfluger Arch.- Eur. J. Physiol. 2004. № 447. P. 465–468.Hediger M.A., Romero M.F., Peng J.-B., Rolfs A., Ta-kanaga H., Bruford E.A. The ABCs of solute carriers: physiological, pathophysiological and therapeutic implications of human membrane transport protein // Pfluger Arch.- Eur. J. Physiol. 2004. № 447. P. 465–468.Gamba G. Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters // Physiol. Rev. 2005. № 85. P. 423–493.Gamba G. Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters // Physiol. Rev. 2005. № 85. P. 423–493.Orlov S.N., Mongin A.A. Salt sensing mechanisms in blood pressure regulation and hypertension // Am. J. Physiol. Heart Circ. Physiol. 2007. № 293. P. H2039–H2053.Orlov S.N., Mongin A.A. Salt sensing mechanisms in blood pressure regulation and hypertension // Am. J. Physiol. Heart Circ. Physiol. 2007. № 293. P. H2039–H2053.Markadieu N., Delpire E. Physiology and pathophysiology of SLC12A1/2 transporters // Pfluger Arch.- Eur. J. Physiol. 2014. № 466. P. 91–105.Markadieu N., Delpire E. Physiology and pathophysiology of SLC12A1/2 transporters // Pfluger Arch.- Eur. J. Physiol. 2014. № 466. P. 91–105.Lang F., Voelkl J. Theraupetic potential of serum and glucocorticoid inducible kinase inhibition // Expert Opin. Investig. Drugs. 2013. № 22. P. 701–714.Lang F., Voelkl J. Theraupetic potential of serum and glucocorticoid inducible kinase inhibition // Expert Opin. Investig. Drugs. 2013. № 22. P. 701–714.Gagnon F., Hamet P., Orlov S.N. Na+,K+ pump and Na+-coupled ion carriers in isolated mammalian kidney epithelial cells: regulation by protein kinase C // Can. J. Physiol. Pharmacol. 1999. № 77. P. 305–319.Gagnon F., Hamet P., Orlov S.N. Na+,K+ pump and Na+-coupled ion carriers in isolated mammalian kidney epithelial cells: regulation by protein kinase C // Can. J. Physiol. Pharmacol. 1999. № 77. P. 305–319.Orlov S.N., Resink T.J., Bernhardt J., Buhler F.R. Na+-K+ pump and Na+-K+ co-transport in cultured vascular smooth muscle cells from spontaneously hypertensive rats: baseline activity and regulation // J. Hypertens. 1992. № 10. P. 733–740.Orlov S.N., Resink T.J., Bernhardt J., Buhler F.R. Na+-K+ pump and Na+-K+ co-transport in cultured vascular smooth muscle cells from spontaneously hypertensive rats: baseline activity and regulation // J. Hypertens. 1992. № 10. P. 733–740.Smith J.B., Smith L. Na+/K+/Cl– cotransport in cultured vascular smooth muscle cells: stimulation by angiotensin II and calcium ionophores, inhibition by cyclic AMP and calmodulin antagonists // J. Membrane Biol. 1987. № 99. P. 51–63.Smith J.B., Smith L. Na+/K+/Cl– cotransport in cultured vascular smooth muscle cells: stimulation by angiotensin II and calcium ionophores, inhibition by cyclic AMP and calmodulin antagonists // J. Membrane Biol. 1987. № 99. P. 51–63.Orlov S.N., Tremblay J., Hamet P. Cell volume in vascular smooth muscle is regulated by bumetanide-sensitive ion transport // Am. J. Physiol. 1996. № 270. P. C1388–C1397.Orlov S.N., Tremblay J., Hamet P. Cell volume in vascular smooth muscle is regulated by bumetanide-sensitive ion transport // Am. J. Physiol. 1996. № 270. P. C1388–C1397.Adragna N., White R.E., Orlov S.N., Lauf P.K. K-Cl cotransport in vascular smooth muscle and erythrocytes: possible implication in vasodilation // Am. J. Physiol. 2000. № 278. P. C381–C390.Adragna N., White R.E., Orlov S.N., Lauf P.K. K-Cl cotransport in vascular smooth muscle and erythrocytes: possible implication in vasodilation // Am. J. Physiol. 2000. № 278. P. C381–C390.Gagnon F., Orlov S.N., Tremblay J., Hamet P. Complete inhibition of Na+,K+,Cl– cotransport in Madin-Darby canine kidney cells by PMA-sensitive protein kinase C // Biochim. Biophys. Acta. 1998. № 1369. P. 233–239.Gagnon F., Orlov S.N., Tremblay J., Hamet P. Complete inhibition of Na+,K+,Cl– cotransport in Madin-Darby canine kidney cells by PMA-sensitive protein kinase C // Biochim. Biophys. Acta. 1998. № 1369. P. 233–239.Gagnon F., Dulin N.O., Tremblay J., Hamet P., Orlov S.N. ATP-induced inhibition of Na+,K+,Cl– cotransport in Madin-Darby canine kidney cells: lack of involvement of known purinoceptor-coupled signaling pathways // J. Membrane Biol. 1999. № 167. P. 193–204.Gagnon F., Dulin N.O., Tremblay J., Hamet P., Orlov S.N. ATP-induced inhibition of Na+,K+,Cl– cotransport in Madin-Darby canine kidney cells: lack of involvement of known purinoceptor-coupled signaling pathways // J. Membrane Biol. 1999. № 167. P. 193–204.Orlov S.N., Dulin N.O., Gagnon F., Gekle M., Douglas J.G., Schwartz J.H., Hamet P. Purinergic regulation of Na+,K+,Cl- cotransport and MAP kinases is limited to C11-MDCK cells resembling intercalated cells from collecting ducts // J. Membrane Biol. 1999. № 172. P. 225–234.Orlov S.N., Dulin N.O., Gagnon F., Gekle M., Douglas J.G., Schwartz J.H., Hamet P. Purinergic regulation of Na+,K+,Cl- cotransport and MAP kinases is limited to C11-MDCK cells resembling intercalated cells from collecting ducts // J. Membrane Biol. 1999. № 172. P. 225–234.Lytle C., Forbush III B. The Na-K-Cl cotransport protein of shark rectal gland. II. Regulation by direct phosphoryla-tion // J. Biol. Chem. 1992. № 267. P. 25438–25443.Lytle C., Forbush III B. The Na-K-Cl cotransport protein of shark rectal gland. II. Regulation by direct phosphoryla-tion // J. Biol. Chem. 1992. № 267. P. 25438–25443.Dowd B.F., Forbush B. PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCK1) // J. Biol. Chem. 2003. № 278. P. 27347–27353.Dowd B.F., Forbush B. PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCK1) // J. Biol. Chem. 2003. № 278. P. 27347–27353.Alvarez-Leefmans F.J. Intracellular chloride regulation // Cell Physiology Source Book. A molecular Approach. Academic, San Diego, CA. 2001. P. 301–318.Alvarez-Leefmans F.J. Intracellular chloride regulation // Cell Physiology Source Book. A molecular Approach. Academic, San Diego, CA. 2001. P. 301–318.Chipperfield A.R., Harper A.A. Chloride in smooth muscle // Prog. Biophys. Mol. Biol. 2001. № 74. P. 175–221.Chipperfield A.R., Harper A.A. Chloride in smooth muscle // Prog. Biophys. Mol. Biol. 2001. № 74. P. 175–221.Davis J.P.L., Chipperfield A.R., Harper A.A. Accumulation of intracellular chloride by (Na-K-Cl) cotransport in rat arterial smooth muscle is enhanced in deoxycorticosterone acetate (DOCA)/salt hypertension // J. Mol. Cell. Cardiol. 1993. № 25. P. 233–237.Davis J.P.L., Chipperfield A.R., Harper A.A. Accumulation of intracellular chloride by (Na-K-Cl) cotransport in rat arterial smooth muscle is enhanced in deoxycorticosterone acetate (DOCA)/salt hypertension // J. Mol. Cell. Cardiol. 1993. № 25. P. 233–237.Anfinogenova Y.J., Baskakov M.B., Kovalev I.V., Kilin A.A., Dulin N.O., Orlov S.N. Cell-volume-dependent vascular smooth muscle contraction: role of Na+,K+,2Cl– cotransport, intracellular Cl- and L-type Ca2+ channels // Pflügers Archiv. 2004. № 449. P. 42–55.Anfinogenova Y.J., Baskakov M.B., Kovalev I.V., Kilin A.A., Dulin N.O., Orlov S.N. Cell-volume-dependent vascular smooth muscle contraction: role of Na+,K+,2Cl– cotransport, intracellular Cl- and L-type Ca2+ channels // Pflügers Archiv. 2004. № 449. P. 42–55.Barthelmebs M., Stephan D., Fontaine C., Grima M., Imbs J.L. Vascular effects of loop diuretics: an in vivo and in vitro study in the rat // Naunyn-Schmiedebergs Arch. Pharmacol. 1994. № 349. P. 209–216.Barthelmebs M., Stephan D., Fontaine C., Grima M., Imbs J.L. Vascular effects of loop diuretics: an in vivo and in vitro study in the rat // Naunyn-Schmiedebergs Arch. Pharmacol. 1994. № 349. P. 209–216.Lavallee S.L., Iwamoto L.M., Claybaugh J.R., Dressel M.V., Sato A.K., Nakamura K.T. Furosemide-induced airway relaxation in guinea pigs: relation to Na-K-2Cl cotransporet function // Am. J. Physiol. 1997. № 273. P. L211–L216.Lavallee S.L., Iwamoto L.M., Claybaugh J.R., Dressel M.V., Sato A.K., Nakamura K.T. Furosemide-induced airway relaxation in guinea pigs: relation to Na-K-2Cl cotransporet function // Am. J. Physiol. 1997. № 273. P. L211–L216.Tian R., Aalkjaer C., Andreasen F. Mechanisms behind the relaxing effect of furosemide on the isolated rabbit ear ar-tery // Pharmacol. Toxicol. 1990. № 67. P. 406–410.Tian R., Aalkjaer C., Andreasen F. Mechanisms behind the relaxing effect of furosemide on the isolated rabbit ear ar-tery // Pharmacol. Toxicol. 1990. № 67. P. 406–410.Kovalev I.V., Baskakov M.B., Anfinogenova Y.J., Borodin Y.L., Kilin A.A., Minochenko I.L., Popov A.G., Kapilevich L.V., Medvedev M.A., Orlov S.N. Effect of Na+,K+,2Cl– cotransport inhibitor bumetanide on electrical and contractile activity of smooth muscle cells in guinea pig ureter // Bull. Exp. Biol. Med. 2003. № 136 (8). P. 145–149.Kovalev I.V., Baskakov M.B., Anfinogenova Y.J., Borodin Y.L., Kilin A.A., Minochenko I.L., Popov A.G., Kapilevich L.V., Medvedev M.A., Orlov S.N. Effect of Na+,K+,2Cl– cotransport inhibitor bumetanide on electrical and contractile activity of smooth muscle cells in guinea pig ureter // Bull. Exp. Biol. Med. 2003. № 136 (8). P. 145–149.Kovalev I.V., Baskakov M.B., Medvedev M.A., Minochenko I.L., Kilin A.A., Anfinogenova Y.J., Borodin I.V., Gusakova S.V., Popov A.G., Kapilevich L.V., Orlov S.N. Na+,K+,2Cl- cotransport and chloride permeability of the cell membrane in mezaton and histamine regulation of electrical and contractile activity in smooth muscle cells from the guinea pig ureter // Russian Physiol. J. 2008. № 93. P. 306–317.Kovalev I.V., Baskakov M.B., Medvedev M.A., Minochenko I.L., Kilin A.A., Anfinogenova Y.J., Borodin I.V., Gusakova S.V., Popov A.G., Kapilevich L.V., Orlov S.N. Na+,K+,2Cl- cotransport and chloride permeability of the cell membrane in mezaton and histamine regulation of electrical and contractile activity in smooth muscle cells from the guinea pig ureter // Russian Physiol. J. 2008. № 93. P. 306–317.Stanke-Labesque F., Craciwski J.L., Bedouch P., Chavanon O., Magne J.L., Bessard G., Devillier P. Furosemide inhibits thrombaxane A2-induced contraction in isolated human internal artery and saphenous vein // J. Cardiovasc. Pharmacol. 2000. № 35. P. 531–537.Stanke-Labesque F., Craciwski J.L., Bedouch P., Chavanon O., Magne J.L., Bessard G., Devillier P. Furosemide inhibits thrombaxane A2-induced contraction in isolated human internal artery and saphenous vein // J. Cardiovasc. Pharmacol. 2000. № 35. P. 531–537.Wang X., Breaks J., Loutzenhiser K., Loutzenhiser R. Ef-fects of inhibition of the Na+/K+/2Cl- cotransporter on myogenic and angiotensin II responses of the rat afferent arteriole // Am. J. Physiol. Renal Physiol. 2007. № 292. P. F999–F1006.Wang X., Breaks J., Loutzenhiser K., Loutzenhiser R. Ef-fects of inhibition of the Na+/K+/2Cl- cotransporter on myogenic and angiotensin II responses of the rat afferent arteriole // Am. J. Physiol. Renal Physiol. 2007. № 292. P. F999–F1006.Mozhayeva M.G., Bagrov Y.Y. The inhibitory effects of furosemide on Ca2+ influx pathways associated with oxytocin-induced contractions of rat myometrium // Gen. Physiol. Biophys. 1995. № 14. P. 427–436.Mozhayeva M.G., Bagrov Y.Y. The inhibitory effects of furosemide on Ca2+ influx pathways associated with oxytocin-induced contractions of rat myometrium // Gen. Physiol. Biophys. 1995. № 14. P. 427–436.Mozhayeva M.G., Bagrov Y.Y., Ostretsova I.B., Gillespie J.I. The effect of furosemide on oxytocin-induced contractions of the rat myometrium // Exp. Physiol. 1994. № 79. P. 661–667.Mozhayeva M.G., Bagrov Y.Y., Ostretsova I.B., Gillespie J.I. The effect of furosemide on oxytocin-induced contractions of the rat myometrium // Exp. Physiol. 1994. № 79. P. 661–667.Akar F., Skinner E., Klein J.D., Jena M., Paul R.J., O'Neill W.C. Vasoconstrictors and nitrovasodilators reciprocally regulate the Na+-K+-2Cl– cotransporter in rat aorta // Am. J. Physiol. 1999. № 276. P. C1383–C1390.Akar F., Skinner E., Klein J.D., Jena M., Paul R.J., O'Neill W.C. Vasoconstrictors and nitrovasodilators reciprocally regulate the Na+-K+-2Cl– cotransporter in rat aorta // Am. J. Physiol. 1999. № 276. P. C1383–C1390.Garg P., Martin C., Elms S.C., Gordon F.J., Wall S.M., Garland C.J., Sutliff R.L., O'Neill W.C. Effect of the Na-K-2Cl cotransporter NKCC1 on systematic blood pressure and smooth muscle tone // Am. J. Physiol. Heart Circ. Physiol. 2007. № 292. P. H2100–H2105.Garg P., Martin C., Elms S.C., Gordon F.J., Wall S.M., Garland C.J., Sutliff R.L., O'Neill W.C. Effect of the Na-K-2Cl cotransporter NKCC1 on systematic blood pressure and smooth muscle tone // Am. J. Physiol. Heart Circ. Physiol. 2007. № 292. P. H2100–H2105.Palacios J., Espinoza F., Munita C., Cifuentes F., Michea L. Na+-K+-2Cl– cotransporter is implicated in gender differences in the response of the rat aorta to phenylephrine // Br. J. Pharmacol. 2006. № 148. P. 964–972.Palacios J., Espinoza F., Munita C., Cifuentes F., Michea L. Na+-K+-2Cl– cotransporter is implicated in gender differences in the response of the rat aorta to phenylephrine // Br. J. Pharmacol. 2006. № 148. P. 964–972.Koltsova S.V., Maximov G.V., Kotelevtsev S.V., Lavoie J.L., Tremblay J., Grygorczyk R., Hamet P., Orlov S.N. Myogenic tome in mouse mesenteric arteries: evidence for P2Y receptor-mediated, Na+,K+,2Cl– cotransport-dependent signaling // Purinergic Signaling. 2009. № 5. P. 343–349.Koltsova S.V., Maximov G.V., Kotelevtsev S.V., Lavoie J.L., Tremblay J., Grygorczyk R., Hamet P., Orlov S.N. Myogenic tome in mouse mesenteric arteries: evidence for P2Y receptor-mediated, Na+,K+,2Cl– cotransport-dependent signaling // Purinergic Signaling. 2009. № 5. P. 343–349.Davis M.J., Hill M.A. Signaling mechanisms underlying the vascular myogenic response // Physiol. Rev. 2009. № 79. P. 387–423.Davis M.J., Hill M.A. Signaling mechanisms underlying the vascular myogenic response // Physiol. Rev. 2009. № 79. P. 387–423.Hill M.A., Davis M.J., Meininger G.A., Potocnik S.J., Mur-phy T.V. Arteriolar myogenic signaling mechanisms: impli-cations for local vascular functions // Clin. Hemorheol. Microcirc. 2006. № 34. P. 67–79.Hill M.A., Davis M.J., Meininger G.A., Potocnik S.J., Mur-phy T.V. Arteriolar myogenic signaling mechanisms: impli-cations for local vascular functions // Clin. Hemorheol. Microcirc. 2006. № 34. P. 67–79.Schubert R., Mulvany M.J. The myogenic response: estab-lished facts and attractive hypothesis // Clin. Sci. 1999. № 96. P. 313–326.Schubert R., Mulvany M.J. The myogenic response: estab-lished facts and attractive hypothesis // Clin. Sci. 1999. № 96. P. 313–326.Koltsova S.V., Kotelevtsev S.V., Tremblay J., Hamet P., Orlov S.N. Excitation-contraction coupling in resistant mesenteric arteries: evidence for NKCC1-mediated pathway // Biochem. Biophys. Res. Commun. 2009. № 379. P. 1080–1083.Koltsova S.V., Kotelevtsev S.V., Tremblay J., Hamet P., Orlov S.N. Excitation-contraction coupling in resistant mesenteric arteries: evidence for NKCC1-mediated pathway // Biochem. Biophys. Res. Commun. 2009. № 379. P. 1080–1083.Lang F., Busch G., Ritter M., Volkl H., Waldegger S., Gulbins E., Haussinger D. Functional significance of cell volume regulatory mechanisms // Physiol. Rev. 1998. № 78. P. 247–306.Lang F., Busch G., Ritter M., Volkl H., Waldegger S., Gulbins E., Haussinger D. Functional significance of cell volume regulatory mechanisms // Physiol. Rev. 1998. № 78. P. 247–306.Mongin A.A., Orlov S.N. Mechanisms of cell volume regulation and possible nature of the cell volume sensor // Pathophysiology. 2001. № 8. P. 77–88.Mongin A.A., Orlov S.N. Mechanisms of cell volume regulation and possible nature of the cell volume sensor // Pathophysiology. 2001. № 8. P. 77–88.Koltsova S.V., Akimova O.A., Orlov S.N., Dulin N.O. Both Na+/K+ pump and Na+,K+,2Cl– cotransport contribute to cell volume control in human lung fibroblasts // Бюл. сиб. медицины. 2013. vol. 12. № 4. P. 42.Koltsova S.V., Akimova O.A., Orlov S.N., Dulin N.O. Both Na+/K+ pump and Na+,K+,2Cl– cotransport contribute to cell volume control in human lung fibroblasts // Бюл. сиб. медицины. 2013. vol. 12. № 4. P. 42.Hoffmann E.K., Lambert I.H., Pedersen S.F. Physiology of cell volume regulation in vertebrates // Physiol. Rev. 2009. № 89. P. 193–277.Hoffmann E.K., Lambert I.H., Pedersen S.F. Physiology of cell volume regulation in vertebrates // Physiol. Rev. 2009. № 89. P. 193–277.Orlov S.N., Platonova A.A., Hamet P., Grygorczyk R. Cell volume and monovalent ion transporters: their role in the triggereing and progression of the cell death machinery // Am. J. Physiol. Cell Physiol. 2013. № 305. P. C361–C372.Orlov S.N., Platonova A.A., Hamet P., Grygorczyk R. Cell volume and monovalent ion transporters: their role in the triggereing and progression of the cell death machinery // Am. J. Physiol. Cell Physiol. 2013. № 305. P. C361–C372.O'Shaughnessy K.M., Karet F.E. Salt handling in hypertension // Annu. Rev. Nutr. 2006. № 26. P. 343–365.O'Shaughnessy K.M., Karet F.E. Salt handling in hypertension // Annu. Rev. Nutr. 2006. № 26. P. 343–365.Guyton A.C. Arterial pressure and hypertension. Philadelphia, WB Saunders Co, 1980.Guyton A.C. Arterial pressure and hypertension. Philadelphia, WB Saunders Co, 1980.Postnov Y.V., Orlov S.N. Primary hypertension as a cell membrane pathology. М.: Медицина, 1987.Postnov Y.V., Orlov S.N. Primary hypertension as a cell membrane pathology. М.: Медицина, 1987.Lifton R.P., Gharavi A.G., Geller D.S. Molecular mecha-nisms of human hypertension // Cell. 2001. № 104. P. 545–556.Lifton R.P., Gharavi A.G., Geller D.S. Molecular mecha-nisms of human hypertension // Cell. 2001. № 104. P. 545–556.Lifton R.P. Genetic dissection of human blood pressure variation: common pathways from rare phenotypes // Harvey Lect. 2005. № 100. P. 71–101.Lifton R.P. Genetic dissection of human blood pressure variation: common pathways from rare phenotypes // Harvey Lect. 2005. № 100. P. 71–101.Simon D.B., Karet F.E., Hamdan J.M., Di Pietro A., San-jad S.A., Lifton R.P. Bartter's syndrome, hypokalemic alka-losis with hypercalciuria, is caused by mutation of Na-K-2Cl cotransporter NKCC2 // Nature Genetics. 1996. № 13. P. 183–188.Simon D.B., Karet F.E., Hamdan J.M., Di Pietro A., San-jad S.A., Lifton R.P. Bartter's syndrome, hypokalemic alka-losis with hypercalciuria, is caused by mutation of Na-K-2Cl cotransporter NKCC2 // Nature Genetics. 1996. № 13. P. 183–188.Simon D.B., Nelson-Williams C., Bia J., Ellison D., Karet F.E., Molina A.M., Vaara I., Iwata F., Cushner M., Koolen M., Gainza F.J., Gitelman H.J., Lifton R.P. Gitelman's varaint of Bartter's syndrome, inhereted hypokalemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter // Nature Genetics. 1996. № 12. P. 24–30.Simon D.B., Nelson-Williams C., Bia J., Ellison D., Karet F.E., Molina A.M., Vaara I., Iwata F., Cushner M., Koolen M., Gainza F.J., Gitelman H.J., Lifton R.P. Gitelman's varaint of Bartter's syndrome, inhereted hypokalemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter // Nature Genetics. 1996. № 12. P. 24–30.Jones A.W. Altered ion transport in vascular smooth muscle from spontaneously hypertensive rats. Influence of aldosterone, norepinephrine and angiotensin // Circ. Res. 1973. № 33. P. 563–572.Jones A.W. Altered ion transport in vascular smooth muscle from spontaneously hypertensive rats. Influence of aldosterone, norepinephrine and angiotensin // Circ. Res. 1973. № 33. P. 563–572.Postnov Yu.V., Orlov S.N., Shevchenko A.S., Adler A.M. Altered sodium permeability, calcium binding and Na-K-ATPase activity in the red blood cell membrane in essential hypertension // Pflugers Archiv. 1977. № 371. P. 263–269.Postnov Yu.V., Orlov S.N., Shevchenko A.S., Adler A.M. Altered sodium permeability, calcium binding and Na-K-ATPase activity in the red blood cell membrane in essential hypertension // Pflugers Archiv. 1977. № 371. P. 263–269.Lee H.-A., Baek I., Seok Y.M., Yang E., Cho H.-M., Lee D.-Y., Hong S.H., Kim I.K. Promoter hypomethylation upregulates Na+-K+-2Cl– cotransporyter 1 in spontaneously hypertensive rats // Biochem. Biophys. Res. Commun. 2010. № 396. P. 252–257.Lee H.-A., Baek I., Seok Y.M., Yang E., Cho H.-M., Lee D.-Y., Hong S.H., Kim I.K. Promoter hypomethylation upregulates Na+-K+-2Cl– cotransporyter 1 in spontaneously hypertensive rats // Biochem. Biophys. Res. Commun. 2010. № 396. P. 252–257.Cho H.-M., Lee H.-A., Kim H.Y., Han H.S., Kim I.K. Expression of Na+,K+-2Cl– cotransporter is epigenetically regulated during postnatal development of hypertension // Am. J. Hypertens. 2011. № 12. P. 1286–1293.Cho H.-M., Lee H.-A., Kim H.Y., Han H.S., Kim I.K. Expression of Na+,K+-2Cl– cotransporter is epigenetically regulated during postnatal development of hypertension // Am. J. Hypertens. 2011. № 12. P. 1286–1293.Ye Z.-Y., Li D.-P., Byun H.S., Li L., Pan H.-L. NKCC1 upregulation disrupts chloride homeostasis in the hypothalamus and increases neuronal-sympathetic drive in hypertension // J. Neurosci. 2012. № 32. P. 8560–8568.Ye Z.-Y., Li D.-P., Byun H.S., Li L., Pan H.-L. NKCC1 upregulation disrupts chloride homeostasis in the hypothalamus and increases neuronal-sympathetic drive in hypertension // J. Neurosci. 2012. № 32. P. 8560–8568.Mancia G., Grassi G., Giannattasio C., Seravalle G. Sympathetic activation in the pathogenesis of hypertension and progression of organ damage // Hypertension. 1999. № 34. P. 724–728.Mancia G., Grassi G., Giannattasio C., Seravalle G. Sympathetic activation in the pathogenesis of hypertension and progression of organ damage // Hypertension. 1999. № 34. P. 724–728.Schlaich M.P., Lambert E., Kaye D.M., Krozowski Z., Campbell D.J., Lambert G., Hastings J., Aggarwal A., Esler M.D. Sympathetic augmentation in hypertension: role of nerve firing, norepinephrine reuptake, and angiotensin neuromodulation // Hypertension. 2004. № 43. P. 169–175.Schlaich M.P., Lambert E., Kaye D.M., Krozowski Z., Campbell D.J., Lambert G., Hastings J., Aggarwal A., Esler M.D. Sympathetic augmentation in hypertension: role of nerve firing, norepinephrine reuptake, and angiotensin neuromodulation // Hypertension. 2004. № 43. P. 169–175.Huang B.S., Amin M.S., Leenen F.H.H. The central role of the brain in salt-sensitive hypertension // Curr. Opin. Cardiol. 2006. № 21. P. 295–394.Huang B.S., Amin M.S., Leenen F.H.H. The central role of the brain in salt-sensitive hypertension // Curr. Opin. Cardiol. 2006. № 21. P. 295–394.Leenen F.H.H. The central role of the brain aldosterone-"ouabain" pathway in salt-sensitive hypertension // Biochim. Biophys. Acta. 2010. № 1802. P. 1132–1139.Leenen F.H.H. The central role of the brain aldosterone-"ouabain" pathway in salt-sensitive hypertension // Biochim. Biophys. Acta. 2010. № 1802. P. 1132–1139.Judy W.V., Watanabe A.M., Henry P.D., Besch H.R., Mur-phy W.R., Hockel G.M. Sympathetic nerve activity: role in regulation of blood pressure in the spontaneously hypertensive rats // Circ. Res. 1976. № 38. P. 21–29.Judy W.V., Watanabe A.M., Henry P.D., Besch H.R., Mur-phy W.R., Hockel G.M. Sympathetic nerve activity: role in regulation of blood pressure in the spontaneously hypertensive rats // Circ. Res. 1976. № 38. P. 21–29.Pyner S., Coote J.H. Identification of branching paraventricular neurins of the hypothalamus that project to the rostroventrolateral medulla and spinal cord // Neurosci. 2000. № 100. P. 549–556.Pyner S., Coote J.H. Identification of branching paraventricular neurins of the hypothalamus that project to the rostroventrolateral medulla and spinal cord // Neurosci. 2000. № 100. P. 549–556.Allen A.M. Inhibition of the hypothalamic paraventricular nucleus in spontaneousl hypertensive rats dramatically re-duces sympathetic vasomotor tone // Hypertension. 2002. № 39. P. 275–280.Allen A.M. Inhibition of the hypothalamic paraventricular nucleus in spontaneousl hypertensive rats dramatically re-duces sympathetic vasomotor tone // Hypertension. 2002. № 39. P. 275–280.

The authors declare that there are no conflicts of interest present.