ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2009-2-85-90ssmu-1795Research ArticleНАУЧНЫЙ И УЧЕБНЫЙ ПРОЦЕСС: МЕТОДИЧЕСКИЙ СЕМИНАРSCIENTIFIC AND STUDYING PROCESS: METHODIC SEMINARРоль лизосомальных цистеиновых протеиназ в опухолевой прогрессииThe role of lysosomal cysteine proteases in tumor progressionКоровинМ. С.KorovinM. S.

Коровин Матвей Сергеевич, аспирант кафедры патофизиологии 

8-913-825-6977

matvei@academ.tsk.ruНовицкийВ. В.NovitskyV. V.

д р мед наук профессор академик РАМН зав кафедрой патофизиологии

ВасильеваО. С.VasiliyevaO. S.

канд мед наук

Сибирский государственный медицинский университетRussian FederationИнститут имени И. СтефанаSlovenia200928042009828590Copyright © Коровин М.С., Новицкий В.В., Васильева О.С., 20092009Коровин М.С., Новицкий В.В., Васильева О.С.Korovin M.S., Novitsky V.V., Vasiliyeva O.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/1795

Cysteine cathepsins have been known for a long time to play an important role in cancer progression. Here we summarize their impact to the hallmark processes of malignant growth such as cell proliferation, apoptosis, angiogenesis, invasion and metastasis. We discuss the molecular mechanisms where cysteine cathepsins are participating through the degradation of the extracellular matrix, initiation of the proteolytic cascade by activating serine proteases and urokinase plasminogen precursors. Moreover, in addition to the tumorigenic and pro-metastatic functions of lysosomal cysteine proteases in the cancer cells, cathepsins originating from cells of the tumour microenvironment has been shown to participate in the processes leading to the tumor progression and metastasis. Taken together, that data support the concept of cysteine cathepsins as promising molecular targets for cancer therapy.

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The authors declare that there are no conflicts of interest present.