ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2009-2-45-49ssmu-1813Research ArticleЭКСПЕРИМЕНТАЛЬНЫЕ И КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯEXPERIMENTAL AND CLINICAL INVESTIGATIONSАнализ ассоциации полиморфных вариантов генов GSTP1 и GSTM1 с выживаемостью больных циррозом печени вирусной и алкогольной этиологииAnalysis of association of polymorphic variants of genes GSTP1 and GSTM1 with survival rate sick of liver cirrhosis of a virus and alcoholic etiologyРачковскийМ. И.RachkovskiyM. I.

Рачковский Максим Игоревич, канд. мед. наук, доцент кафедры госпитальной терапии с курсом физической реабилитации и спортивной медицины

тел.: 8-903-950-3802

rachkovskii@rambler.ruГончароваИ. А.GoncharovaI. A.

канд биол наук научный сотрудник

БелобородоваЭ. И.BeloborodovaE. I.

д р мед наук профессор зав кафедрой терапии ФПК и ППС

БелобородоваЕ. В.BeloborodovaYe. V.

д р мед наук профессор кафедры терапии ФПК и ППС

ГруздеваЕ. Г.GruzdevaYe. G.

врач гастроэнтеролог

АлексееваА. С.AlekseyevaA. S.

канд мед наук врач гастроэнтеролог зам главного врача по лечебной работе

ПузырёвВ. П.PuzyryovV. P.

д р мед наук профессор академик РАМН зав кафедрой медицинской генетики 

директор 

Сибирский государственный медицинский университетRussian FederationНИИ медицинской генетики СО РАМНRussian FederationОГУЗ «Томская областная клиническая больница»Russian Federation200928042009824549Copyright © Рачковский М.И., Гончарова И.А., Белобородова Э.И., Белобородова Е.В., Груздева Е.Г., Алексеева А.С., Пузырёв В.П., 20092009Рачковский М.И., Гончарова И.А., Белобородова Э.И., Белобородова Е.В., Груздева Е.Г., Алексеева А.С., Пузырёв В.П.Rachkovskiy M.I., Goncharova I.A., Beloborodova E.I., Beloborodova Y.V., Gruzdeva Y.G., Alekseyeva A.S., Puzyryov V.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/1813

With the purpose of studying of association of polymorphic variants of genes glutathione S-transferases pi and mu (GSTP1 and GSTM1) with survival rate sick of liver cirrhosis (LC), it is lead uniinstantly research of 189 sick of LC of a virus (HBV, HCV, H V+H V) and an alcoholic etiology. Have been В С compared a frequencies of allocation of polymorphic variants of genes GSTP1 and GSTM1 between the died and persisted patients for the season 4 years. With greater survival rate of sick of LC associated: presence of genotype АА of gene GSTP1 (χ 2 Pearson, р = 0,008) and «null» genotype GSTM1 (χ 2 Pearson, р = 0,027). Chances of development of a lethal outcome at sick of LC with presence of genotypes GG and AG on gene GSTP1 in 2,5 times above, than at patients with genotype АА. Presence of active gene replica GSTM1 enlarges chances of development of a lethal outcome in 2 times. The received results testify to necessity of the count of genetical factors for the forecast of LC.

полиморфизм геновцирроз печенипрогнозpolymorphism genesliver cirrhosisforecastReferencesКуценко С.А. Основы токсикологии. СПб.: Фолиант, 2002. 720 с.Куценко С.А. Основы токсикологии. СПб.: Фолиант, 2002. 720 с.Мазур И.А., Волошин Н.А., Чекман И.С. и др. Клиническое применение тиотриазолина в терапии//Сучасна гастроентерологія. 2005. Т. 25. № 5. С. 76-79.Мазур И.А., Волошин Н.А., Чекман И.С. и др. Клиническое применение тиотриазолина в терапии//Сучасна гастроентерологія. 2005. Т. 25. № 5. С. 76-79.Cholongitas E., Papatheodoridis G.V., Vangeli M. et al. Systematic Review: The Model for End-Stage Liver Disease -Should it Replace Child-Pugh's Classification for Assessing Prognosis in Cirrhosis?//Aliment. Pharmacol. Ther. 2005. V. 22. № 11. Р. 1079-1089.Cholongitas E., Papatheodoridis G.V., Vangeli M. et al. Systematic Review: The Model for End-Stage Liver Disease -Should it Replace Child-Pugh's Classification for Assessing Prognosis in Cirrhosis?//Aliment. Pharmacol. Ther. 2005. V. 22. № 11. Р. 1079-1089.Hayes J.D., Strange R.C. Glutathione S-transferase polymorphisms and their biological consequences//Pharmacology. 2000. V. 61. P. 154-166.Hayes J.D., Strange R.C. Glutathione S-transferase polymorphisms and their biological consequences//Pharmacology. 2000. V. 61. P. 154-166.Ishii T., Matsuse T., Teramoto S. et al. Glutathione S-transferase P1 (GSTP1) polymorphism in patients with chronic obstructive pulmonary disease//Thorax. 1999. V. 54. P. 693-696.Ishii T., Matsuse T., Teramoto S. et al. Glutathione S-transferase P1 (GSTP1) polymorphism in patients with chronic obstructive pulmonary disease//Thorax. 1999. V. 54. P. 693-696.Kandemir O., Tamer L., Tasdelen B. Effects of GSTT1, GSTM1 and GSTP1 gene polymorphism on the course of hepatitis B virus infection//Hepatogastroenterology. 2008. V. 55. № 86-87. P. 1729-1733.Kandemir O., Tamer L., Tasdelen B. Effects of GSTT1, GSTM1 and GSTP1 gene polymorphism on the course of hepatitis B virus infection//Hepatogastroenterology. 2008. V. 55. № 86-87. P. 1729-1733.Lahiri D.K., Bye S., Nurnberger J.I. et al. A non-organic and non-enzymatic extraction method gives higher yields of genomic DNA from whole-blood samples than do nine other methods tested//J. Biochem and Biophys. Methods. 1992. V. 25. P.193-205.Lahiri D.K., Bye S., Nurnberger J.I. et al. A non-organic and non-enzymatic extraction method gives higher yields of genomic DNA from whole-blood samples than do nine other methods tested//J. Biochem and Biophys. Methods. 1992. V. 25. P.193-205.Mohammadzadeh Ghobadloo S., Yaghmaei B., Allameh A. et al. Polymorphisms of glutathione S-transferase M1, T1, and P1 in patients with HBV-related liver cirrhosis, chronic hepatitis, and normal carriers//Clin. Biochem. 2006. V. 39. № 1. P. 46-49.Mohammadzadeh Ghobadloo S., Yaghmaei B., Allameh A. et al. Polymorphisms of glutathione S-transferase M1, T1, and P1 in patients with HBV-related liver cirrhosis, chronic hepatitis, and normal carriers//Clin. Biochem. 2006. V. 39. № 1. P. 46-49.Norppa H. Cytogenetic biomarkers and genetic polymorphisms//Toxicol. Lett. 2004. V. 149. P. 309-334.Norppa H. Cytogenetic biomarkers and genetic polymorphisms//Toxicol. Lett. 2004. V. 149. P. 309-334.Spurdle A.B., Webb P.M., Purdie D.M. et al. Polymorphisms at the glutathione S-transfrase GSTM1, GSTT1 and GSTP1 loci: risk of ovarian cancer by histological subtype//Carcinogenesis. 2001. V. 22. P. 67-72.Spurdle A.B., Webb P.M., Purdie D.M. et al. Polymorphisms at the glutathione S-transfrase GSTM1, GSTT1 and GSTP1 loci: risk of ovarian cancer by histological subtype//Carcinogenesis. 2001. V. 22. P. 67-72.Stickel F., Osterreicher C.H. The role of genetic polymorphisms in alcoholic liver disease//Alcohol Alcohol. 2006. V. 41. № 3. P. 209-224.Stickel F., Osterreicher C.H. The role of genetic polymorphisms in alcoholic liver disease//Alcohol Alcohol. 2006. V. 41. № 3. P. 209-224.White D.L., Li D., Nurgalieva Z., El-Serag H.B. Genetic Variants of Glutathione S-Transferase as Possible Risk Factors for Hepatocellular Carcinoma: A HuGE Systematic Review and Meta-Analysis//Am. J. Epidemiol. 2008. V. 167. № 4. Р. 377-389.White D.L., Li D., Nurgalieva Z., El-Serag H.B. Genetic Variants of Glutathione S-Transferase as Possible Risk Factors for Hepatocellular Carcinoma: A HuGE Systematic Review and Meta-Analysis//Am. J. Epidemiol. 2008. V. 167. № 4. Р. 377-389.

The authors declare that there are no conflicts of interest present.