ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2009-4-41-46ssmu-1885Research ArticleЭКСПЕРИМЕНТАЛЬНЫЕ И КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯEXPERIMENTAL AND CLINICAL INVESTIGATIONSВлияние перекиси водорода на сократительную активность гладкомышечных клеток: роль цитоскелетаHydrogen peroxide influence on contractile activity smooth muscle cells: the role of cytoskeletonКовалевИ. В.KovalyevI. V.

Ковалев Игорь Викторович, д р мед наук профессор профессор кафедры биофизики и функциональной диагностики

(3822) 42-09-54

Kovalew@mail.ruГусаковаС. В.GusakovaS. V.

канд мед наук доцент кафедры биофизики и функциональной диагностики

МельникО. С.MelnikO. S.

аспирант кафедры биофизики и функциональной диагностики

БаскаковМ. Б.BaskakovM. B.

д р мед наук профессор зав кафедрой биофизики и функциональной диагностики

КапилевичЛ. В.KapilevichL. V.

д р мед наук профессор кафедры биофизики и функциональной диагностики

МедведевМ. А.MedvedevM. A.

д р мед наук профессор академик РАМН зав кафедрой нормальной физиологии

СтудницкийВ. Б.StudnitskyV. B.

канд биол наук доцент кафедры нормальной физиологии

АнтоновО. И.AntonovO. I.

аспирант кафедры нормальной физиологии

Сибирский государственный медицинский университетRussian Federation200928082009844146Copyright © Ковалев И.В., Гусакова С.В., Мельник О.С., Баскаков М.Б., Капилевич Л.В., Медведев М.А., Студницкий В.Б., Антонов О.И., 20092009Ковалев И.В., Гусакова С.В., Мельник О.С., Баскаков М.Б., Капилевич Л.В., Медведев М.А., Студницкий В.Б., Антонов О.И.Kovalyev I.V., Gusakova S.V., Melnik O.S., Baskakov M.B., Kapilevich L.V., Medvedev M.A., Studnitsky V.B., Antonov O.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/1885

The influence of of hydrogen peroxide on the contractile reactions of smooth muscle cells caused by hyperpotassium solution end phenylephrine in modulation a potassium conductance the membrane and the state of cytoskeleton elements has been investigated by the mechanographical method. It has multidirectional influence of hydrogen peroxide in the reduction of smooth muscles of rat aorta with the membrane depolarization hyperpotassium solution and action phenylephrine: phenylephrine decline in value and increase strength hyperpotassium contractures. We show that the cytoskeleton components involved in the mechanisms of action of hydrogen peroxide in the contractile reactions of smooth muscles of rat aorta caused by phenylephrine.

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The authors declare that there are no conflicts of interest present.