To study influence of therapy Biltritsid and Ursosan on existence of cholelithiasis at opisthorchosis. Are inspected 87 patients with the cholelithiasis and chronic opisthorchosis. There were carried out in the investigating groups the analysis of the clinical, laboratory and instrument criterias of biliar and gastrointestinal disfunction. In patients with the cholelithiasis, in combination with opisthorchosis is revealed the low effect from conducting of litolithic therapy, which comprises not more than 20%. Conducting litolithic therapy after the preliminary antihelminthic therapy by Biltritsid makes it possible to achieve the significant litolithic effect, to the larger degree at the early stages of cholelithiasis, that composes 72,3% and 53,8% into 2 and 3 stages of cholelithiasis.