ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2018-4-254-263ssmu-1998Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESЭпикардиальная жировая ткань: патофизиология и роль в развитии сердечно-сосудистых заболеванийEpicardial adipose tissue: pathophysiology and role in the development of cardiovascular diseaseshttps://orcid.org/0000-0003-4321-8977УчасоваЕ. Г.UchasovaE. G.

Учасова Евгения Геннадьевна, кандидат медицинских наук, старший научный сотрудник, лаборатория исследований гомеостаза отдела диагностики сердечно-сосудистых заболеваний

650002, г. Кемерово, Сосновый бульвар, 6

Uchasova Eveniya G., PhD, Senior Researcher, Laboratory Research Homeostasis

 6, Sosnovy Blv., Kemerovo, 650002

evg.uchasova@yandex.ruhttps://orcid.org/0000-0002-7780-829XГруздеваО. В.GruzdevaO. V.

Груздева Ольга Викторовна, доктор медицинских наук, заведующая лабораторией исследований гомеостаза отдела диагностики сердечно-сосудистых заболеваний, НИИ КПССЗ, г. Кемерово; доцент, кафедра паталогической физиологии, медицинской и клинической биохимии, КГМУ

650002, г. Кемерово, Сосновый бульвар, 6, 

650056, г. Кемерово, ул. Ворошилова, 22а

Gruzdeva Olgа V., DM, Нead of the Laboratory Research Homeostasis, SIRICICD; Аssociate Рrofessor, Department of Pathological Physiology, Medical and Clinical Biochemistry, KSMU

 6, Sosnovy Blv., Kemerovo, 650002, 

22, Vorocshilov Str., Kemerovo, 650056

https://orcid.org/0000-0002-6890-3287ДылеваЮ. А.DylevaYu. A.

Дылева Юлия Александровна, кандидат медицинских наук, старший научный сотрудник, лаборатория исследований гомеостаза отдела диагностики сердечно-сосудистых заболеваний

650002, г. Кемерово, Сосновый бульвар, 6

Dyleva Yuliya A., PhD, Senior Researcher, Laboratory Research Homeostasis

 6, Sosnovy Blv., Kemerovo, 650002

https://orcid.org/0000-0003-0680-8249АкбашеваО. Е.AkbashevaO. E.

Акбашева Ольга Евгеньевна, доктор медицинских наук, профессор, кафедра биохимии и молекулярной биологии с курсом клинической лабораторной диагностики

634050, г. Томск, Московский тракт, 2

Akbasheva Olga E., DM, Professor, Department of Biochemistry and Molecular Biology with Course of Clinical Laboratory Diagnostic

2, Mosсow Trakt, Tomsk, 634050

Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний (НИИ КПССЗ)РоссияScientific Institution Research Institute for Complex Issues of Cardiovascular Diseases (SIRICICD)Russian FederationНаучно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний (НИИ КПССЗ); Кемеровский государственный медицинский университет (КГМУ)РоссияScientific Institution Research Institute for Complex Issues of Cardiovascular Diseases (SIRICICD); Kemerovo State Medical University (КSМU)Russian FederationСибирский государственный медицинский университет (СибГМУ)РоссияSiberian State Medical University (SSMU)Russian Federation201824122018174254263Copyright © Учасова Е.Г., Груздева О.В., Дылева Ю.А., Акбашева О.Е., 20182018Учасова Е.Г., Груздева О.В., Дылева Ю.А., Акбашева О.Е.Uchasova E.G., Gruzdeva O.V., Dyleva Y.A., Akbasheva O.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/1998

Висцеральная жировая ткань является важным предиктором сердечно-метаболических заболеваний, несущих больше риска, чем общее накопление жира. Эпикардиальный жир, особая форма висцерального жира, депонированная вокруг сердца, считается важным предиктором риска сердечнососудистых заболеваний с учетом производства и высвобождения адипоцитокинов. В последнее время увеличивается количество экспериментальных и клинических данных, доказывающих физиологическую и метаболическую значимости эпикардиального жира. Толщина и объем эпикардиальной жировой ткани (ЭЖТ) имеют сильную корреляцию с ожирением, нарушением уровня глюкозы натощак, инсулинорезистентностью, метаболическим синдромом и атеросклерозом. Более того, теперь понятно, что связь между ЭЖТ и сердцем регулируется сложными двунаправленными путями, поскольку не только адипокины регулируют сердечную функцию, но и сердце влияет на ЭЖТ через паракринную «обратную» сигнализацию. Дальнейшее изучение молекулярных механизмов, регулирующих взаимодействие между сердцем и ЭЖТ, улучшит наше понимание роли последнего в сердечной физиологии и развитии соответствующих механизмов заболевания.

Visceral adipose tissue is an important predictor of cardiovascular diseases, which carry more risk than total fat accumulation. Epicardial fat, a special form of visceral fat deposited around the heart, is considered an important predictor of the risk of cardiovascular disease, taking into account the production and release of adipocytokines. Recently, the number of experimental and clinical data proving the physiological and metabolic significance of epicardial fat is increasing. The thickness and volume of epicardial adipose tissue (EAT) have a strong correlation with obesity, impaired fasting glucose, insulin resistance, metabolic syndrome and atherosclerosis. Moreover, it is now clear that the connection between EAT and the heart is regulated by complex two directional pathways, since not only adipokines regulate cardiac function, but the heart affects EAT via paracrine signaling. Further study of the molecular mechanisms regulating the interaction between the heart and EAT will improve our understanding of the role of the latter in cardiac physiology and the development of disease mechanisms.

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The authors declare that there are no conflicts of interest present.