ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2015-4-60-67ssmu-209Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL PAPERSНОВЫЙ МЕТОДОЛОГИЧЕСКИЙ ПОДХОД К СОЗДАНИЮ ПЕРСОНИФИЦИРОВАННОЙ ЭЛИМИНАЦИОННОЙ ДИЕТЫ ПРИ ПИЩЕВОЙ НЕПЕРЕНОСИМОСТИ, ОБУСЛОВЛЕННОЙ ИММУНОПАТОЛОГИЧЕСКИМИ РЕАКЦИЯМИ III ТИПАNEW METHODOLOGICAL APPROACH TO THE CREATION OF A PERSONALIZED ELIMINATION DIET IN FOOD INTOLERANCE CAUSED BY TYPE III IMMUNOPATHOLOGICAL REACTIONSРозенштейнМ. Ю.RosensteynM. Yu.

Розенштейн Марина Юзефовна – PhD, врач диетолог-эндокринолог

chna@0370.ruРозенштейнА. З.RosensteynA. Z.

Розенштейн Аркадий Зильманович – доктор физико-математических наук, управляющий партнер клиники ImmunoHealth Int.

chna@0370.ruКондаковС. Э.KondakovS. E.chna@0370.ruЧеревкоН. А.CherevkoN. A.chna@0370.ruКлиника ImmunoHealth, Нью-ЙоркСоединённые Штаты АмерикиImmunoHealthInt., New YorkUnited StatesМосковский государственный университет им. М.В. Ломоносова, МоскваРоссияM.V. Lomonosov Moscow State UniversityRussian FederationСибирский государственный медицинский университет, ТомскРоссияSiberian State Medical University, TomskRussian Federation2015280820151446067Copyright © Розенштейн М.Ю., Розенштейн А.З., Кондаков С.Э., Черевко Н.А., 20152015Розенштейн М.Ю., Розенштейн А.З., Кондаков С.Э., Черевко Н.А.Rosensteyn M.Y., Rosensteyn A.Z., Kondakov S.E., Cherevko N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/209

Предложен новый методологический подход к обработке и дана интерпретация данных от много-компонентного иммуносорбентного ферментного анализа ELISA IgG. Показана возможность определения критерия «норма-патология» на основе исследования вида функции распределения плотности вероятности IgG иммунных откликов в интегральном IgG-иммунном ответе. Показана возможность унифицированной диагностики гиперчувствительности III типа у пациентов с раз-личными уровнями пищевой дезадаптации и симптомов патологических реакций на пищевые антигены

A new methodological approach to analysis and interpretation of data from a multifaceted analysis ELISA IgG has been provided. The possibility for identification of a “norma-pathology” criterion, on the basis of research yielding a frequency spectrum (or probability density function-PDF) of IgG-immune responses in the integral IgG-immune reply is shown. The possibility for unified diagnostic of hypersensi-tivity type III in patients with varying levels of food disadaptation and symptoms of pathological reac-tions to food antigens is shown too. 

пищевая непереносимостьиммуносорбентный ферментный анализиммуноглобулины Gиммунопатологические реакции III типапищевая дезадаптациятест ELISA IgGfood intolerancehypersensitivity type IIIELISA IgGimmunoglobulins Gadverse re-actions to foodfooddisadaptationReferencesВоейков В.Л., Розенталь В.М. Методы подбора индивидуального питания // Рос. журн. гастроэнтерологии, гепато-логии, колопроктологии. 2001. Т. ХI, № 4. С. 155–162.Voeykov V.L., Rozental V.M. Metody podbora individual'nogo pitaniya [Methods of selection of individual nutrition]. Rossiyskiy zhurnal gastroenterologii, gepatologii, koloproktologii – Russian Journal of Gastroenterology, Hepatology, Coloproctology, 2001, vol. Х1, no. 4, pp. 155–162 (in Russian).Brostoff J., Challacombe S.J. Food allergy and intolerance. Saunders, 2002. 276 p.Brostoff J., Challacombe S.J. Food allergy and intolerance. Saunders, 2002, 276 p.Барановский А.Ю., Назаренко Л.И., Райхельсон К.Л. Пищевая непереносимость: учеб.-метод. пособие. СПб., 2006. 135 с.Baranovsky A.Yu., Nazarenko L.I., Rayhel'son K.L. Pische-vaya neperenosimost': ucheb.-metod. Posobie [Food intole-rance]. St. Petersburg, 2006. 135 p. (in Russian).Roitt I. Essential immunology. Wiley-Blackwell, 2006. 496 p.Roitt I. Essential immunology. Wiley-Blackwell, 2006. 496 p.Bentz S., Hausmann M., Piberger H. et al. Clinical relevance of IgG antibodies against food antigens in crohn’s disease: a double-blind cross-over diet intervention study // Digestion. 2010. V. 81. P. 252–264.Bentz S., Hausmann M., Piberger H. et al. Clinical relevance of IgG antibodies against food antigens in crohn’s disease: a doubleblind crossover diet intervention study. Digestion, 2010, vol. 81, pp. 252–264.Hong Guo, Tao Jiang, Jinliang Wang et al. The value of eliminating foods according to food-specific immunoglobulin G an-tibodies in irritable bowel syndrome with diarrhea // Journal of International Medical Research. 2012. V. 40. P. 204–210.Hong Guo, Tao Jiang, Jinliang Wang et al. The value of eliminating foods according to food-specific immunoglobu-lin G antibodies in irritable bowel syndrome with diarrhea. Journal of International Medical Research, 2012, vol. 40, pp. 204–210.Alpay K., Ertas M., Orhan E.K. et al. Diet restriction in mi-graine, based on IgG against foods: A clinical double-blind, randomized, cross-over trial // Cephalalgia. 2010. V. 30. P. 829–837.Alpay K., Ertas M., Orhan E.K. et al. Diet restriction in migraine, based on IgG against foods: A clinical double-blind, randomized, crossover trial. Cephalalgia, 2010, vol. 30, pp. 829–837.Elif Ilgaz Aydinlar, Pinar Yalinay Dikmen et al. IgG-based elimination diet in migraine plus irritable bowel syndrome // Headache. 2012. American Headache Society.ElifIlgaz Aydinlar, Pinar Yalinay Dikmen et al. IgG-based elimination diet in migraine plus irritable bowel syndrome. Headache, 2012, American Headache Society.Pelsser L.M., Frankena K., Toorman J., Huub F. at al. Ef-fects of a restricted elimination diet on the behavior of chil-dren with attention-deficit hyperactivity disorder (INCA study): a randomized controlled trial // Lancet. 2011. V. 377. P. 494–503.Pelsser L.M., Frankena K., Toorman J., Huub F. et al. Effects of a restricted elimination diet on the behavior of chil-dren with attention-deficit hyperactivity disorder (INCA study): a randomized controlled trial. Lancet, 2011, vol. 377, pp. 494–503.Lewis J.E., Lopez J., Ganuza A., Judi M. et al. A pilot study eliminating immunologically-reactive foods from the diet and its effect on symptomatology and quality of life in per-sons with chronic migraines and headaches // Open Journal of Internal Medicine. 2013. V. 3. P. 8–14.Lewis J.E., Lopez J., Ganuza A., Judi M. et al. A pilot study eliminating immunologically-reactive foods from the diet and its effect on symptomatology and quality of life in per-sons with chronic migraines and headaches. Open Journal of Internal Medicine, 2013, vol. 3, pp. 8–14.Wilders-Truschnig M., Mangge H., Lieners C. et al. IgG an-tibodies against food antigens are correlated with inflamma-tion and intima media thickness in obese juveniles // Exp. Clin. Endocrinol. Diabetes. 2008. V. 116. P. 241–245.Wilders-Truschnig M., Mangge H., Lieners C. et al. IgG antibodies against food antigens are correlated with inflamma-tion and intima media thickness in obese juveniles. Exp. Clin. Endocrinol. Diabetes, 2008, vol. 116, pp. 241–245.Hicks K., Hart G. Role for food-specific IgG-based elimina-tion diets // Nutrition & Food Science. 2008. V. 38, № 5. P. 404–416.Hicks K., Hart G. Role for food-specific IgG-based elimination diets. Nutrition & Food Science, 2008, vol. 38, no. 5, pp. 404–416.Drisko J., Bischoff B., Hall M., McCallum R. Treating irritable bowel syndrome with a food elimination diet followed by food challenge and probiotics // J. Am. Coll. Nutr. 2006. V. 25. P. 514–522.Drisko J., Bischoff B., Hall M., McCallum R. Treating irri-table bowel syndrome with a food elimination diet followed by food challenge and probiotics. J. Am. Coll. Nutr., 2006, vol. 25, pp. 514–522.Arroyave Hernandez C.M., Echavarria Pinto M., Hernandez Montiel H.L. Food allergy mediated by IgG antibodies asso-ciated with migraine in adults // Rev. Allerg. Mex. 2007. V. 54. P. 162–168.Arroyave Hernandez C.M., Echavarria Pinto M., Hernandez Montiel H.L. Food allergy mediated by IgG antibodies asso-ciated with migraine in adults. Rev. Allerg. Mex., 2007, vol. 54, pp. 162–168.Atkinson W., Sheldon T.A., Shaath N., Whorwell P.J. Food elimination based on IgG antibodies in irritable bowel syn-drome: A randomized controlled trial // Gut. 2004. V. 53. P. 1459–1464.Atkinson W., Sheldon T.A., Shaath N., Whorwell P.J. Food elimination based on IgG antibodies in irritable bowel syndrome: A randomized controlled trial. Gut, 2004, vol. 53, pp. 1459–1464.Yang C.M., Li Y.Q. The therapeutic effects of eliminating allergy foods according to food-specific IgG antibodies in irri-table bowelsyndrome // Zhonghua Nei Ke Za Zhi. 2007. V. 46. P. 641–643.Yang C.M., Li Y.Q. The therapeutic effects of eliminating allergy foods according to food-specific IgG antibodies in irritable bowelsyndrome. Zhonghua Nei Ke Za Zhi, 2007, vol. 46, pp. 641–643.Zavik J.S. The case for testing a chronically ill patient's ad-verse reactions to foods // Original Internist. 2004. V. 11, № 1. P. 5–11.Zavik J.S. The case for testing a chronically ill patient's adverse reactions to foods. Original Internist, 2004, vol. 11, no. 1, pp. 5–11.Розенштейн М.Ю., Розенштейн А.З., Кондаков С.Э., Черевко Н.А. Динамика специфических IgG к пищевым антигенам, как персонифицированный маркер состояния иммунной системы человека» // Медикус. 2015. № 4 (4). С. 31–34.Rozenshteyn M.Yu., Rozenshteyn A.Z., Kondakov S.E., Cherevko N.A. Dinamika specificheskih IgG k pishhevym antigenam kak personificirovannyj marker sostoyaniya immunnoy sistemy cheloveka [Dynamics of specific IgE to food antigens as a personified marker of the human immune system]. Medikus – Medicus, 2015, no. 4 (4), pp. 31–34 (in Russian).Rozeshteyn A.Z., Rozenshteyn M.Y., Volkov A.V. Method of analysis, detection and correction of food intolerance in humans: patent WO 2009/035529 A1, US Patent Appl. 20100227340.Rozeshteyn A.Z., Rozenshteyn M.Y., Volkov A.V. Method of analysis, detection and correction of food intolerance in Humans: patent WO 2009/035529 A1, US Patent Appl. 20100227340.Розенштейн М.Ю., Ихалайнен Е.С., Кондаков С.Э., Прокопцева О.С., Розенштейн А.З. Применение методологии неспецифических биосенсоров в иммунологии на примере интерпретации титров специфических IgG человека // Вестник Мос. ун-та. Сер. 2, Химия. 2011. Т. 52, № 3. С. 230–236.Rozenshteyn M.Yu., Ihalainen E.S., Kondakov S.E., Prokop-zeva O.S., Rozenshteyn A.Z. Primenenie metodologii nespecificheskih biosensorov v immunologii na primere interpretacii titrov specificheskih IgG cheloveka [Application of nonspecific biosensors methodology forright choice of diag-nostic criteria for food allergy andintolerance on the basis specific human IgG determination]. Vestnik Moskovskogo universiteta. Seriya 2, Himiya – MSU Vestnik. Series 2. Chemistry, 2011, vol. 52, no. 3, pp. 230–236 (in Russian).Розенштейн А.З., Розенштейн М.Ю., Кондаков С.Э., Черевко Н.А. Диагностика пищевой гиперчувствительности, опосредованной иммунопатологическими реакция-ми III типа // Рос. иммунол. журнал. 2015. Т. 9 (18), № 2. С. 150–153.Rozenshteyn A.Z., Rozenshteyn M.Yu., Kondakov S.Ye., Cherevko N.A. Diagnostika pishhevoy giperchuvstvitel'nosti, oposredovannoy immunopatologicheskimi reakciyami III tipa [Diagnosis of food hypersensitivity, mediated immunopathological reactions type III]. Rossijskiy immunologicheskiy zhurnal – Russian Journal of Immunology, 2015, vol. 9 (18), no. 2, pp. 150–153 (in Russian).Dehmeratall M. Applied statistics for network biology: methods in systems biology. Wiley-Blackwell, 2011. 478 р.Dehmeratall M. Applied statistics for network biology: Methods in systems biology. Wiley-Blackwell, 2011. 478 р.Егоров А.М., Осипов А.П., Дзантиев Б.Б., Гаврилов Е.М. Теория и практика иммуноферментного анализа. М.: Высшая школа, 1991. 288 с.Yegorov A.M., Osipov A.P., Dzantiev B.B., Gavrilov Ye.M. Teoriya i praktika immunnofermentnogo analiza [Theory and practice of immune enzyme analysis]. Moscow, Vysshaya shkola Publ., 1991. 288 p. (in Russian).Свежова Н.В., Шаркова В.Е., Громов Д.Б., Головаченко В.А., Полынцев Д. Методы математической обра-ботки данных в иммуноферментном анализе. I. Теоретические основы // Клиническая лабораторная диагности-ка. 2008. № 1. С. 3–10.Svezhova N.V., Sharkova V.Ye., Gromov D.B., Golovachenko V.A., Polyntsev D.G. Metody matematicheskoy obrabotki dannyh v immunofermentnom analize. I. Teoreticheskie osnovy [Methods for mathematical data processing in enzyme immunoassay. I. Theoretical bases]. Klinicheskaya Laboratornaya Diagnostika, 2008, no. 1, pp. 3–10 (in Russian).Бендат Дж., Пирсол А. Прикладной анализ случайных данных. М.: Мир, 1989. 540 с.Bendat J., Pirsol A. Prikladnoy analiz sluchainyh dannyh [Applied analysis of random data]. Moscow, Mir Publ., 1989. 540 p. (in Russian).

The authors declare that there are no conflicts of interest present.