ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2019-1-7-17ssmu-2166Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESИммунная парадигма и иммуносупрессорная доминанта в патогенезе основных заболеваний современного человекаImmune paradigm and immunosuppressive dominance in the pathogenesis of major diseases of the modern manКозловВ. А.KozlovV. A.

Козлов Владимир Александрович, доктор медицинских наук, профессор, академик РАН, вице-президент Российского научного общества иммунологов, научный руководитель НИИФКИ

630099, г. Новосибирск, ул. Ядринцевская, 14

Kozlov Vladimir A., DM, Рrofessor, Аcademician of RAS, Scientific Adviser of RIFCI, Vice-president of the Russian Society for Immunology

14, Yadrintsevskaya Str., Novosibirsk, 630099

vakoz40@yandex.ruНаучно-исследовательский институт фундаментальной и клинической иммунологии (НИИФКИ)РоссияResearch Institute of Fundamental and Clinical Immunology (RIFCI)Russian Federation201916052019181717Copyright © Козлов В.А., 20192019Козлов В.А.Kozlov V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/2166

В статье обсуждается определяющая роль иммунопатогенеза основных заболеваний современного человека (рак, атеросклероз, аутоиммунные, аллергические и инфекционные заболевания). В этом отношении вводится понятие «иммунная парадигма». Представлены доказательства, что любая патология связана с классическим иммунным ответом к антигену, будь то ауто- или ксеноантиген, со всеми стадиями его развития и параллельным изменением состояния иммунной толерантности: ее «полома» (в случаях аутоиммунных и аллергических заболеваний и атеросклероза) и установления (при онкологических и инфекционных заболеваниях). Вместе с тем подчеркивается, что в основе иммунопатогенеза лежит недостаточная или повышенная функция иммунокомпетентных регуляторных клеток с супрессорной активностью. Вводится понятие «иммуносупрессорная доминанта». Обсуждается необходимость принципиальных изменений в терапии указанных заболеваний, где ведущее место должны занять молекулярные и клеточные методы иммунотерапии с разработкой комплексных подходов к их применению.

 

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The authors declare that there are no conflicts of interest present.