ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2019-1-18-29ssmu-2167Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESИндуцированная иммуносупрессия в критических состояниях: диагностические возможности в клинической практикеInduced immunosuppression in critical care: diagnostic opportunities in clinical practicehttps://orcid.org/0000-0002-3898-0740ГригорьевЕ. В.GrigoryevE. V.

Григорьев Евгений Валерьевич, доктор медицинских наук, профессор, заместитель директора по научной и лечебной работе, ведущий научный сотрудник, НИИ КПССЗ; заведующий кафедрой анестезиологии и реаниматологии, КемГМУ

650002, г. Кемерово, Сосновый бульвар, 6,

650000, г. Кемерово, ул. Ворошилова, 22

Grigoryev Evgeny V., DM, Рrofessor, Deputy Director for Scientific and Clinical Affairs, RICICD; Нead of the Аnesthesiology and Сritical Сare Department, KemSMU

6, Sosnovy Blv., Kemerovo, 650002, 

22, Voroshilov Str., Kemerovo, 650000

grigorievev@hotmail.comhttps://orcid.org/0000-0002-4146-3373МатвееваВ. Г.MatveevaV. G.

Матвеева Вера Геннадьевна, кандидат медицинских наук, старший научный сотрудник, лаборатория клеточных технологий, НИИ КПССЗ

650002, г. Кемерово, Сосновый бульвар, 6

Matveeva Vera G., PhD, Senior Rresearcher, Laboratory for Cell Technologies

6, Sosnovy Blv., Kemerovo, 650002

https://orcid.org/0000-0001-5708-2463ШукевичД. Л.ShukevichD. L.

Шукевич Дмитрий Леонидович, доктор медицинских наук, заведующий лабораторией критических состояний, НИИ КПССЗ; профессор кафедры анестезиологии и реаниматологии, КемГМУ

650002, г. Кемерово, Сосновый бульвар, 6,

650000, г. Кемерово, ул. Ворошилова, 22

Shukevich Dmitriy L., DM, Нead of Laboratory for Сritical Сare, RICICD; Рrofessor, Аnesthesiology and Сritical Сare Department, KemSMU

6, Sosnovy Blv., Kemerovo, 650002, 

22, Voroshilov Str., Kemerovo, 650000

https://orcid.org/0000-0001-8743-4466РадивилкоА. С.RadivilkoA. S.

Радивилко Артем Сергеевич, кандидат медицинских наук, старший научный сотрудник, лаборатория критических состояний

650002, г. Кемерово, Сосновый бульвар, 6

Radivilko Artem S., PhD, Senior Rresearcher, Laboratory for Сritical Сare

6, Sosnovy Blv., Kemerovo, 650002

https://orcid.org/0000-0002-1079-1956ВеликановаЕ. А.VelikanovaE. A.

Великанова Елена Анатольевна, кандидат биологических наук, научный сотрудник, лаборатория клеточных технологий

650002, г. Кемерово, Сосновый бульвар, 6

Velikanova Elena A., PhD, Researcher, Laboratory for Cell Technologies

6, Sosnovy Blv., Kemerovo, 650002

https://orcid.org/0000-0002-8826-9244ХановаМ. Ю.KhanovaM. Yu.

Ханова Марьям Юрисовна, лаборант-исследователь, лаборатория клеточных технологий

650002, г. Кемерово, Сосновый бульвар, 6

Khanova Maryam Yu., Researcher, Laboratory for Cell Technologies

6, Sosnovy Blv., Kemerovo, 650002

Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний (НИИ КПССЗ); Кемеровский государственный медицинский университет (КемГМУ)РоссияResearch Institute for Complex Issues in Cardiovascular Diseases (RICICD); Kemerovo State Medical University (KemSTU)Russian FederationНаучно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний (НИИ КПССЗ)РоссияResearch Institute for Complex Issues in Cardiovascular Diseases (RICICD)Russian Federation2019160520191811829Copyright © Григорьев Е.В., Матвеева В.Г., Шукевич Д.Л., Радивилко А.С., Великанова Е.А., Ханова М.Ю., 20192019Григорьев Е.В., Матвеева В.Г., Шукевич Д.Л., Радивилко А.С., Великанова Е.А., Ханова М.Ю.Grigoryev E.V., Matveeva V.G., Shukevich D.L., Radivilko A.S., Velikanova E.A., Khanova M.Y.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/2167

Иммунная система в критических состояниях инициирует локальное воспаление в области повреждения, при дисбалансе местных и системных реакций воспаления инфекционного или неинфекционного генеза развивается системный воспалительный ответ, который характеризуется стадийностью «гипервоспаление – компенсаторная антивоспалительная реакция» с вероятным исходом в полиорганную недостаточность. Финальная стадия критического состояния, следовательно, будет характеризоваться индуцированной иммуносупрессией с нарушением функции нейтрофилов, моноцитов и макрофагов, дендритных клеток, выбросом супрессорных клеток миелоидного происхождения. Цель обзора – оценка вклада различных компонентов иммунной реакции в формирование индуцированной иммунной супрессии с позиции кандидатных диагностических маркеров.

The immune system in critical illnesses initiates local inflammation in the damaged area. In the absence of a balance between local and systemic inflammations, an infectious or non-infectious systemic inflammatory response follows, which has a stage of "hyper inflammation - compensatory anti-inflammatory response", that may result in multi-organ failure. The final stage of critical ill-nesses, therefore, will be characterized by induced immunosuppression with the impaired function of neutrophils, monocytes, macrophages and dendritic cells and release of myeloid-derived suppres-sor cells. The aim of the review is to evaluate the contribution of various components of the im-mune response to the formation of induced immune suppression from the perspective of candidate diagnostic markers.

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The authors declare that there are no conflicts of interest present.