ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2019-1-109-118ssmu-2175Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESПреодоление защитных функций макрофагов факторами вирулентности Streptococcus pyogenesOvercoming the protective functions of macrophages by Streptococcus pyogenes virulence factorshttps://orcid.org/0000-0001-6637-3481ФрейдлинИ. С.FreydlinI. S.

Фрейдлин Ирина Соломоновна, докторр медицинских наук, профессор, член-корреспондент РАН, главный научный сотрудник, отдел иммунологии, Институт ýкспериментальной медицины; кафедра иммунологии, ПСПбГМУ имени академика И.П. Павлова

197376, г. Санкт-Петербург, ул. Академика Павлова, 12, 

197022, г. Санкт-Петербург, ул. Льва Толстого, 6-8

Freydlin Irina S., DM, Professor, Corresponding Member RAS, Main Researcher, Department of Immunology, Institute of Experimental Medicine; Department of Immunology, Pavlov First Saint Petersburg State Medical University

12, Akademika Pavlova Str., St. Petersburg, 197376, 

6-8, L’va Tolstogo Str., Saint Petersburg, 197022

irinaf-n@yandex.ruhttps://orcid.org/0000-0002-9687-7434СтариковаЭ. А.StarikovaE. A.

Старикова Элеонора Александровна, кандидат биологических наук, старший научный сотрудник, отдел иммунологии

197376, г. Санкт-Петербург, ул. Академика Павлова, 12

Starikova Eleonora A., PhD, Senior Researcher, Department of Immunology, Institute of Experimental Medicine, St. Petersburg, Russian Federation. Department of Immunology

12, Akademika Pavlova Str., St. Petersburg, 197376

https://orcid.org/0000-0002-4951-8447ЛебедеваА. М.LebedevaA. M.

Лебедева Александра Михайловна кандидат биологических наук, научный сотрудник, отдел иммунологии

197376, г. Санкт-Петербург, ул. Академика Павлова, 12

Lebedeva Aleksandra M., PhD, Researcher, Department of Immunology

12, Akademika Pavlova Str., St. Petersburg, 197376

Институт экспериментальной медицины; Первый Санкт-Петербургский государственный медицинский университет (ПСПбГМУ) имени академика И.П. ПавловаРоссияInstitute of Experimental Medicine; Pavlov First Saint Petersburg State Medical UniversityRussian FederationИнститут экспериментальной медициныРоссияInstitute of Experimental MedicineRussian Federation201916052019181109118Copyright © Фрейдлин И.С., Старикова Э.А., Лебедева А.М., 20192019Фрейдлин И.С., Старикова Э.А., Лебедева А.М.Freydlin I.S., Starikova E.A., Lebedeva A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/2175

Обзор посвящен анализу молекулярных механизмов действия факторов вирулентности S. pyogenes, направленных на преодоление защитных функций макрофагов. Подробно описаны основные защитные функции макрофагов и механизмы их реализации в ходе развития стрептококковой инфекции. Рассмотрены факторы вирулентности S. pyogenes, препятствующие рекрутированию макрофагов в очаг инфекции. Особое внимание уделено анализу молекулярных механизмов подавления патогеном процесса фагоцитоза, внутриклеточной бактерицидности и продукции цитокинов макрофагами. Проведен анализ молекулярно-генетических механизмов регуляции экспрессии факторов вирулентности S. pyogenes, обеспечивающих адаптацию патогена к меняющимся условиям в очаге воспаления.

The review is devoted to the analysis of molecular mechanisms of action of S. pyogenes virulence factors aimed at overcoming the protective functions of macrophages. The review describes in detail the main protective functions of macrophages and the mechanisms of their implementation in the course of streptococcal infection. The virulence factors of S. pyogenes, which prevent the recruitment of macrophages to the site of infection, are examined. Particular attention is paid to the analysis of molecular effects that suppress the pathogen by the process of phagocytosis, intracellular bactericidal activity and the production of cytokines by macrophages. The analysis of molecular genetic mechanisms of regulation of the expression of S. pyogenes virulence factors that provide adaptation of the pathogen to changing conditions in the site of inflammation is carried out.

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The authors declare that there are no conflicts of interest present.