ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2019-1-131-141ssmu-2177Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESГенетические факторы, влияющие на проникновение ВИЧ в клетку-мишеньGenetic factors influencing HIV entry into target cellshttps://orcid.org/0000-0003-3064-8871ХаитовР. М.KhaitovR. M.

Хаитов Рахим Мусаевич, доктор медицинских наук, профессор, академик РАН, научный руководитель Института иммунологии

115478, г. Москва, Каширское шоссе, 24

Khaitov Rahim M., DM, Professor, Academician of the RAS, Scientific Director of the Institute of Immunology

24, Kashirskoye Sh., Moscow, 115478

https://orcid.org/0000-0003-0432-9439АлексеевЛ. П.AlexeevL. P.

Алексеев Леонид Петрович, доктор медицинских наук, профессор, член-корреспондент РАН, зав. отделом, Институт иммунологии

115478, г. Москва, Каширское шоссе, 24

Alekseev Leonid P., DM, Professor, Corresponding Мember of the RAS, Head of the Department, Institute of Immunology

24, Kashirskoye Sh., Moscow, 115478

https://orcid.org/0000-0001-9280-8282КофиадиИ. А.KofiadiI. A.

Кофиади Илья Андреевич, доктор биологических наук, заведующий лабораторией

115478, г. Москва, Каширское шоссе, 24

Kofiadi Ilya A., DBSc, Head of the Laboratory, Institute of Immunology

24, Kashirskoye Sh., Moscow, 115478

https://orcid.org/0000-0003-2864-6949ГудимаГ. О.GudimaG. O.

Гудима Георгий Олегович, доктор биологических наук, заведующий лабораторией

115478, г. Москва, Каширское шоссе, 24

Gudima Georgy O., DBSc, Head of the Laboratory, Institute of Immunology

24, Kashirskoye Sh., Moscow, 115478

goudima@mail.ruИнститут иммунологииРоссияInstitute of ImmunologyRussian Federation201916052019181131141Copyright © Хаитов Р.М., Алексеев Л.П., Кофиади И.А., Гудима Г.О., 20192019Хаитов Р.М., Алексеев Л.П., Кофиади И.А., Гудима Г.О.Khaitov R.M., Alexeev L.P., Kofiadi I.A., Gudima G.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/2177

Восприимчивость к ВИЧ-инфекции, а также динамика развития заболевания носят индивидуальный характер. Раскрытие генетических основ естественной резистентности к ВИЧ чрезвычайно важно для выработки эффективных стратегий контроля заболевания. Обзор посвящен анализу аллельных вариантов генов хозяина, которые кодируют рецепторы и их лиганды, участвующие в процессе проникновения вируса в клетку-мишень. Эти аллельные варианты и их сочетания способны оказывать значимое влияние на устойчивость либо чувствительность индивидуума к ВИЧ-инфекции, а также могут быть ассоциированы со скоростью прогрессии ВИЧ-инфекции в СПИД.

Succeptibility to HIV and the dynamics of HIV infection progression to AIDS are dependent on unique individual factors. Revealing genetic features of natural resistance to HIV infection is of great importance for the development of effective strategies for disease control. This review presents an analysis of host gene alleles coding receptors and their ligands participating in viral entrance to target cell. These allelic variants and their combinations can have a significant influence on the individual resistance/sensitivity to HIV infection and may be associated with the HIV infection progression to AIDS.

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The authors declare that there are no conflicts of interest present.