References

ssmu

Бюллетень сибирской медицины

Bulletin of Siberian Medicine

1682-03631819-3684

Siberian State Medical University, the Ministry of Healthcare of the Russian Federation

10.20538/1682-0363-2019-2-234-247

ssmu-2322

Research Article

ОБЗОРЫ И ЛЕКЦИИ

REVIEW AND LECTURES

Мембранная теория патогенеза артериальной гипертензии: что мы знаем об этом полвека спустя?

Membrane theory of the pathogenesis of arterial hypertension: What do we know about this, half a century later?

Орлов

С. Н.

Orlov

S. N.

Орлов Сергей Николаевич, д-р биол наук, профессор119991, г. Москва, ул. Ленинские Горы, 1

634050, г. Томск, пр. Ленина, 36

634050, г. Томск, Московский тракт, 2

Orlov Sergey N., DBSc, Professor1, Leninskie Gory Str., Moscow, 119991

36, Lenina Av., Tomsk, 634050

2, Mosсow Trakt, Tomsk, 634050

sergeiorlov@yandex.ru

Московский государственный университет (МГУ) им. М.В. Ломоносова; Национальный исследовательский Томский государственный университет (НИ ТПУ); Сибирский государственный медицинский университет (СибГМУ)РоссияLomonosov Moscow State University; National Research Tomsk State University; Siberian State Medical UniversityRussian Federation

2019

11082019

182234247

2019

Орлов С.Н.

Orlov S.N.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://bulletin.ssmu.ru/jour/article/view/2322

В обзоре кратко изложена история открытия в середине 1970-х гг. нарушений ионного транспорта через плазматические мембраны клеток при первичной артериальной гипертензии. Анализируется полувековая история исследований молекулярной природы ионных транспортеров, лежащих в основе этих нарушений, и опосредованных ими механизмов, приводящих к развитию гипертонической болезни и осложнений, обусловленных долгосрочным повышением артериального давления.

The review summarizes the history of the discovery in the mid-70s of the impaired ion transport across the plasma membrane of cells during primary arterial hypertension. A half-century’s history of studies on the molecular nature of the ionic transporters underlying these disorders and the mechanisms mediated by them leading to the development of hypertension and complications caused by a long-term increase in blood pressure is analyzed.

ионные транспортерыплазматические мембраны клеток.

ion transportersplasma membrane of cells

Работа была поддержана грантами Канадского института исследований в области здравоохранения (MOP-81392), Обществ по изучению сердца и почек Канады, Федераль- ной целевой программой 2009–2013 гг. «Научно-исследовательские кадры инновационной России», Российским фондом фундаментальных исследований (09-0073/04; 15-04-08832; 18-04-00063) и Российским научным фондом (14-15-00006 и 16-15-10026).

This work was supported by grants from the Canadian Institute of Health Research (MOP-81392), Canadian scientific societies of the heart and kidneys, and the 2009–2013 Federal Targeted Program “Scientific and Scientific-Pedagogical Human Resources of Innovation-Driven Russia”, the Russian Foundation for Basic Research (09-0073 / 04; 15-04-08832; 18-04-00063) and the Russian Science Foundation (14-15-00006 and 16-15-10026)

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The authors declare that there are no conflicts of interest present.