ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2014-5-149-159ssmu-234Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESПАЛЬМИТИНОВАЯ, ОЛЕИНОВАЯ КИСЛОТЫ И ИХ РОЛЬ В ПАТОГЕНЕЗЕ АТЕРОСКЛЕРОЗАPALMITIC AND OLEIC ACIDS AND THEIR ROLE IN PATHOGENESIS OF ATHEROSCLEROSISТитовВ. Н.TitovV. N.bolshakova_e_v@mail.ruДыгайА. М.DygaiA. M.bolshakova_e_v@mail.ruКотловскийМ. Ю.KotlovskiyM. Yu.bolshakova_e_v@mail.ruКурдоякЕ. В.KurdoyakYe. V.

Kurdoyak Yevgeniya V.

bolshakova_e_v@mail.ruЯкименкоА. В.YakimenkoA. V.bolshakova_e_v@mail.ruЯкимовичИ. Ю.YakimovichI. Yu.bolshakova_e_v@mail.ruАксютинаН. В.AksyutinaN. V.bolshakova_e_v@mail.ruКотловскийЮ. В.KotlovskiyYu. V.bolshakova_e_v@mail.ruРоссийский кардиологический научно-производственный комплекс Министерства здравоохранения РФ, МоскваРоссияResearch Institute of Pharmacology, Siberian Branch of the Russian Academy of Medical Sciences, TomskRussian FederationНИИ фармакологии СО РАМН, ТомскРоссияResearch Institute of Pharmacology, Siberian Branch of the Russian Academy of Medical Sciences, TomskRussian FederationКрасноярский государственный медицинский университет им. профессора В.Ф. Войно-Ясенецкого, КрасноярскРоссияV.F. Voino-Yasenetsky Krasnoyarsk State Medical University, KrasnoyarskRussian FederationСибирский государственный медицинский университет, ТомскРоссияV.F. Voino-Yasenetsky Krasnoyarsk State Medical University, KrasnoyarskRussian Federation201428102014135149159Copyright © Титов В.Н., Дыгай А.М., Котловский М.Ю., Курдояк Е.В., Якименко А.В., Якимович И.Ю., Аксютина Н.В., Котловский Ю.В., 20142014Титов В.Н., Дыгай А.М., Котловский М.Ю., Курдояк Е.В., Якименко А.В., Якимович И.Ю., Аксютина Н.В., Котловский Ю.В.Titov V.N., Dygai A.M., Kotlovskiy M.Y., Kurdoyak Y.V., Yakimenko A.V., Yakimovich I.Y., Aksyutina N.V., Kotlovskiy Y.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/234

С позиций филогенетической теории общей патологии, если частота неинфекционного заболевания в популяции превышает 5–7%, причина кроется в нарушении биологических функций и биологических реакций in vivo в ответ на воздействие внешней среды. С позиций общей биологии высокий уровень смертности от сердечно-сосудистой патологии, атеросклероза (дефицита в клетках полиеновых жирных кислот (ПНЖК)) – это не более, чем вымирание части популяции Homo sapiens при адаптации к новым воздействиям внешней среды. Факторов нарушения биологической функции трофологии (питания), биологической реакции внешнего питания (экзотрофии) много, основным является афизиологично высокое содержание в пище насыщенных жирных кислот (ЖК), в первую очередь пальмитиновой. Образованная на ранних ступенях филогенеза система липопротеинов (ЛП) не в состоянии переносить к клеткам и физиологично депонировать столь большое количество пальмитиновой насыщенной ЖК; постепенно формируется болезнь адаптации (компенсации) и болезнь накопления. Это влечет за собой гиперлипидемию, нарушение биодоступности для клеток ПНЖК; компенсаторный синтез гуморальных медиаторов из ω-9 эйкозатриеновой мидовой ЖК; нарушение физиологичных параметров мембраны клеток, функции интегральных протеинов; афизиологичную конформацию апоВ-100 в ЛП, формирование безлигандных ЛП (биологического «мусора») и нарушение биологической функции эндоэкологии; утилизацию безлигандных ЛП в интиме артерий филогенетически ранними макрофагами, которые не гидролизуют полиеновые эфиры холестерина; повышение активности биологической реакции воспаления и деструктивно-воспалительное поражение интимы артерий по типу атероматоза или атеротромбоза. Атероматозные массы – катаболиты тех ПНЖК, которые не смогли рецепторным путем поглотить филогенетически более поздние клетки.

On the basis of phylogenetic theory of general pathology, the cause of a noninfectious disease whose occurrence in a population is more than 5–7% is an impaired biological function or reaction to the environment. From the general biology viewpoint, high mortality rate related to cardio-vascular diseases and atherosclerosis (intercellular deficiency of polyenic fatty acids (PFA)) is just extinction of the Homo sapiens population upon adaptation to new environmental factors. The biological function of throphology (feeding) and biological reaction of exotrophy (external feeding) are impaired in several aspects, the major of which is nonphysiologically high dietary content of saturated fatty acids, primarily, of palmitic fatty acid (FA). The lipoprotein system formed at early stages of phylogenesis cannot transport and provide physiological deposition of great amounts of palmitic FA, which leads to the development of an adaption (compensatory) and accumulation disease. This results in hypermipidemia, impaired bioavailability of PFA to cells, compesatory production of humoral mediators from ω-9 eicosatrienoic mead FA, disorders in physiological parameters of cell plasma membrane and integral proteins, nonphysiological conformation of apoВ-100 in lipoproteins, formation of ligandless lipoproteins (biological litter) and impairments in the biological function of endoecology, utilization of ligandless lipoproteins in arterial intima by phylogenetically early macrophages that do not hydrolyze polyenic cholesterol esters, increase in the intensity of the biological reaction of inflammation, and destructive and inflammatory lesions in arterial intima of an atheromatosis or atherothrombosis type. Atheromatous masses are catabolites of PFA which were not internalized by phylogenetically late cells via receptor-mediated pathway.

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The authors declare that there are no conflicts of interest present.