ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2014-5-169-178ssmu-236Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESЭНДОТЕЛИАЛЬНАЯ ДИСФУНКЦИЯ У МУЖЧИН: ВЗГЛЯД КЛИНИЦИСТАENDOTHELIAL DYSFUNCTION IN MEN - A CLINICAL VIEWХрипунИ. А.KhripunI. A.

Хрипун Ирина Алексеевна — кандидат медицинских наук

Khripun Irina A.

khripun.irina@gmail.comГусоваЗ. Р.GtisovaZ. R.

Гусова Залина Руслановна — кандидат медицинских наук

khripun.irina@gmail.comИбишевХ. С.IbishevH. S.

Ибишев Халид Сулейманович — доктор медицинских наук, профессор

khripun.irina@gmail.comСултанмурадоваА. С.SultanmuradovaA. S.

Султанмурадова Асият Сулеймановна — аспирант

khripun.irina@gmail.comВоробьевС. В.VorobievS. V.

Воробьев Сергей Владиславович — доктор медицинских наук, профессор

khripun.irina@gmail.comКоганМ. И.KoganM. I.

Коган Михаил Иосифович — доктор медицинских наук, профессор

khripun.irina@gmail.comРостовский государственный медицинский университет, Ростов-на-ДонуРоссияRostov State Medical University, Rostov-on-DonRussian Federation201428102014135169178Copyright © Хрипун И.А., Гусова З.Р., Ибишев Х.С., Султанмурадова А.С., Воробьев С.В., Коган М.И., 20142014Хрипун И.А., Гусова З.Р., Ибишев Х.С., Султанмурадова А.С., Воробьев С.В., Коган М.И.Khripun I.A., Gtisova Z.R., Ibishev H.S., Sultanmuradova A.S., Vorobiev S.V., Kogan M.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/236

Дисфункция эндотелия является ранним маркером развития и прогрессии сердечно-сосудистых заболеваний. Научные исследования последних лет доказали необходимость изучения функции эндотелия у разных категорий больных в широкой клинической практике. Данная статья представляет возможности и перспективы клинического использования лабораторных и инструментальных методик исследования функции эндотелия. Одним из факторов, провоцирующих развитие сосудистой патологии у мужчин, является дефицит тестостерона. В обзоре отражены наиболее важные механизмы действия половых гормонов на эндотелий сосудов и его функцию у мужчин. Проведен критический анализ данных о влиянии заместительной гормональной терапии тестостероном на функцию эндотелия у лиц с возрастным гипогонадизмом.

Endothelial dysfunction is an early marker for the development and progression of cardiovascular diseases. Scientific studies in recent years have shown the necessity to study the endothelial function in different groups of patients in clinical practice. This article is focused on the possibilities and perspectives for clinical use of laboratory and instrumental methods for the study of endothelial function. One of the factors causing the development of vascular disease in men is testosterone deficiency. The review highlights the most important mechanisms of action of sex hormones on the vascular endothelium and its function in men. The data about the effects of hormone replacement therapy with testosterone on endothelial function in patients with late onset hypogonadism were critically analyzed.

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The authors declare that there are no conflicts of interest present.