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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ssmu</journal-id><journal-title-group><journal-title xml:lang="ru">Бюллетень сибирской медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of Siberian Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-0363</issn><issn pub-type="epub">1819-3684</issn><publisher><publisher-name>Siberian State Medical University, the Ministry of Healthcare of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20538/1682-0363-2019-3-37-45</article-id><article-id custom-type="elpub" pub-id-type="custom">ssmu-2397</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL PAPERS</subject></subj-group></article-categories><title-group><article-title>Вентиляция и механика дыхания у больных хронической обструктивной болезнью легких при разном положении тела</article-title><trans-title-group xml:lang="en"><trans-title>Ventilation and respiration mechanics in patients with chronic obstructive pulmonary disease in different body positions</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1574-5243</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Диш</surname><given-names>Ал. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Dish</surname><given-names>Al. Ju.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, доцент, кафедра пропедевтики внутренних болезней с курсом терапии,</p><p>634050, г. Томск, Московский тракт, 2</p></bio><bio xml:lang="en"><p>PhD, Associate Professor, Department of Рropaedeutics of Internal Diseases with a Course of Therapy,</p><p>2, Moscow Trakt, Tomsk, 634050</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3741-1706</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Диш</surname><given-names>Ан. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Dish</surname><given-names>An. Ju.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач анестезиолог-реаниматолог, отделение анестезиологии и реанимации, факультетские клиники,</p><p>634050, г. Томск, Московский тракт, 2</p></bio><bio xml:lang="en"><p>Anesthesiologist-resuscitationist, Department of Anesthesiology and Resuscitation, Faculty Clinics,</p><p>2, Moscow Trakt, Tomsk, 634050</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2788-6668</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Агеева</surname><given-names>Т. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Ageeva</surname><given-names>T. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, профессор, зав. кафедрой пропедевтики внутренних болезней с курсом терапии,</p><p> </p></bio><bio xml:lang="en"><p>DM, Professor, Нead of the Department of Рropaedeutics of Internal Diseases with a Course of Therapy,</p><p>2, Moscow Trakt, Tomsk, 634050</p></bio><email xlink:type="simple">ageeva.ts@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карзилов</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Karzilov</surname><given-names>A. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, профессор, кафедра пропедевтики внутренних болезней с курсом терапии,</p><p>634050, г. Томск, Московский тракт, 2</p></bio><bio xml:lang="en"><p>DM, Professor, Department of Рropaedeutics of Internal Diseases with a Course of Therapy,</p><p>2, Moscow Trakt, Tomsk, 634050</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4323-2798</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тетенева</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Teteneva</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, зам. главного врача по медицинской части, 634040, г. Томск, ул. Бела Куна, 3 ;</p><p>доцент, кафедра пропедевтики внутренних болезней с курсом терапии, 634050, г. Томск, Московский тракт, 2</p></bio><bio xml:lang="en"><p>DM, Deputy Chief Medical Officer, 3, Bela Kuna Str., Tomsk, 634040;</p><p>Associate Professor, Department of Рropaedeutics of Internal Diseases with a Course of Therapy, 2, Moscow Trakt, Tomsk, 634050</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4292-7723</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Калачева</surname><given-names>Т. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Kalacheva</surname><given-names>T. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, доцент, кафедра общей врачебной практики и поликлинической терапии,</p><p>634050, г. Томск, Московский тракт, 2</p></bio><bio xml:lang="en"><p>PhD, Associate Professor, Department of General Practice and Outpatient Therapy, </p><p>2, Moscow Trakt, Tomsk, 634050</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2183-4402</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Месько</surname><given-names>П. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Mesko</surname><given-names>P. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, доцент, кафедра пропедевтики внутренних болезней с курсом терапии,</p><p>634050, г. Томск, Московский тракт, 2</p></bio><bio xml:lang="en"><p>PhD, Associate Professor, Department of Рropaedeutics of Internal Diseases with a Course of Therapy,</p><p>2, Moscow Trakt, Tomsk, 634050</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мишустина</surname><given-names>Е. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Mishustina</surname><given-names>E. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, доцент, кафедра пропедевтики внутренних болезней с курсом терапии,</p><p>634050, г. Томск, Московский тракт, 2</p></bio><bio xml:lang="en"><p>PhD, Associate Professor, Department of Рropaedeutics of Internal Diseases with a Course of Therapy,</p><p>2, Moscow Trakt, Tomsk, 634050</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9762-6365</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зайцева</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zaytseva</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант, кафедра пропедевтики внутренних болезней с курсом терапии,</p><p>634050, г. Томск, Московский тракт, 2</p></bio><bio xml:lang="en"><p>PhD Student, Department of Рropaedeutics of Internal Diseases with a Course of Therapy,</p><p>2, Moscow Trakt, Tomsk, 634050</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5919-5098</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Параева</surname><given-names>О. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Paraeva</surname><given-names>O. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>пульмонолог,</p><p>656045, г. Барнаул, Змеиногорский тракт, 75</p></bio><bio xml:lang="en"><p>Pulmonologist,</p><p>75, Zmeinogorsky Trakt, Barnaul, 656045</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4513-6329</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Беспалова</surname><given-names>И. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Bespalova</surname><given-names>I. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, профессор, кафедра госпитальной терапии с курсом реабилитации, физиотерапии и спортивной медицины,</p><p>634050, г. Томск, Московский тракт, 2</p></bio><bio xml:lang="en"><p>DM, Professor, Department of Hospital Therapy with a Course of Rehabilitation, Physiotherapy and Sports Medicine,</p><p>2, Moscow Trakt, Tomsk, 634050</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5780-6660</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черногорюк</surname><given-names>Г. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernogoryuk</surname><given-names>G. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, профессор, кафедра госпитальной терапии с курсом реабилитации, физиотерапии и спортивной медицины,</p><p>634050, г. Томск, Московский тракт, 2</p></bio><bio xml:lang="en"><p>DM, Professor, Department of Hospital Therapy with a Course of Rehabilitation, Physiotherapy and Sports Medicine,</p><p>2, Moscow Trakt, Tomsk, 634050</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Сибирский государственный медицинский университет (СибГМУ)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Siberian State Medical University (SSMU)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Сибирский государственный медицинский университет (СибГМУ)&#13;
634050, г. Томск, Московский тракт, 2</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Siberian State Medical University (SSMU)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Медико-санитарная часть № 2;&#13;
Сибирский государственный медицинский университет (СибГМУ)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Medical and Sanitary Hospital № 2;&#13;
Siberian State Medical University (SSMU)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Городская больница № 5</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Сity Hospital 5</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>27</day><month>10</month><year>2019</year></pub-date><volume>18</volume><issue>3</issue><fpage>37</fpage><lpage>45</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Диш А.Ю., Диш А.Ю., Агеева Т.С., Карзилов А.И., Тетенева А.В., Калачева Т.П., Месько П.Е., Мишустина Е.Л., Зайцева А.А., Параева О.С., Беспалова И.Д., Черногорюк Г.Э., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Диш А.Ю., Диш А.Ю., Агеева Т.С., Карзилов А.И., Тетенева А.В., Калачева Т.П., Месько П.Е., Мишустина Е.Л., Зайцева А.А., Параева О.С., Беспалова И.Д., Черногорюк Г.Э.</copyright-holder><copyright-holder xml:lang="en">Dish A.J., Dish A.J., Ageeva T.S., Karzilov A.L., Teteneva A.V., Kalacheva T.P., Mesko P.E., Mishustina E.L., Zaytseva A.A., Paraeva O.S., Bespalova I.D., Chernogoryuk G.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://bulletin.ssmu.ru/jour/article/view/2397">https://bulletin.ssmu.ru/jour/article/view/2397</self-uri><abstract><p>Целью данной работы являлось изучение особенностей изменения механических свойств легких при хронической обструктивной болезни легких (ХОБЛ) в целом и по зонам в зависимости от положения тела.</p><sec><title>Материалы и методы</title><p>Материалы и методы. Исследование выполнено у 37 пациентов с ХОБЛ в вертикальном и горизонтальном положениях (ВП и ГП).</p></sec><sec><title>Результаты</title><p>Результаты. При исследовании интегральной механики дыхания было установлено снижение динамической растяжимости и повышение общего неэластического сопротивления легких на выдохе в ГП по сравнению с ВП. При этом, несмотря на повышение значений общего неэластического сопротивления на выдохе (ОНСвыд) в горизонтальном положении, не отмечалось увеличения общей работы дыхания. У пациентов с ХОБЛ, в отличие от здоровых лиц, регистрировалось исчезновение различий регионарных механических характеристик как в ВП, так и ГП тела. Отсутствовали различия в механике дыхания верхних, средних и нижних регионов левого легкого, зоны правого легкого различались лишь по показателям регионарной неэластической работы дыхания (НРДр ), которые увеличивались по направлению сверху вниз. В нижней зоне по сравнению с верхней большие значения показателей НРДр на вдохе (НРДвдр ) и НРДр на выдохе (НРДвыдр ) отмечены при ВП и ГП тела.</p></sec><sec><title>Заключение</title><p>Заключение. Полученные данные противоречат доминирующему мнению об усугублении регионарных различий вентиляции и механики дыхания под влиянием развивающихся в легких очаговых и диффузных воспалительно-склеротических патологических изменений и эмфиземы. </p></sec></abstract><trans-abstract xml:lang="en"><p>The aim of this work was to study changes in mechanical lung properties in cases of COPD in general and in different zones depending on the body position.</p><sec><title>Materials and methods</title><p>Materials and methods. The research was performed in 37 patients with chronic obstructive pulmonary disease (COPD) in the vertical and horizontal positions (VP and HP).</p></sec><sec><title>Results</title><p>Results. The analysis of integral respiration mechanics has revealed a reduction in dynamic lung compliance and an increase in total non-elastic lung resistance during expiration (TNRexp) in HP vs. VP. At the same time, despite the increase in TNRexp in HP, the total work of breathing did not increase. Unlike healthy individuals, the COPD patients were characterized by the absence of differences in regional mechanical properties in both VP and HP. There were no differences in the respiration mechanics of the left lung, and the zones of the right lung only differed in the parameters of regional non-elastic work of breathing (NWBr ) that was increasing from top downwards: the indicators of NWBr during expiration and NWBr in the lower zone were higher as opposed to those of the upper zone in VP. As for HP, NWBr during inspiration, NWBr during expiration and NWBr were higher.</p></sec><sec><title>Conclusion</title><p>Conclusion. The data obtained contradict the prevailing opinion about an escalation in regional differences in ventilation and respiration mechanics under the influence of emerging focal and diffuse inflammatorysclerotic pathological changes in lungs and emphysema. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>хроническая обструктивная болезнь легких</kwd><kwd>регионарная механика дыхания</kwd><kwd>интегральная механика дыхания</kwd><kwd>вертикальное положение тела</kwd><kwd>горизонтальное положение тела</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic obstructive pulmonary disease</kwd><kwd>regional respiration mechanics</kwd><kwd>integral respiration mechanics</kwd><kwd>vertical body position</kwd><kwd>horizontal body position</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Banzett R.B., Loring S.H. Heavy breathing. J. Appl. Physiol. 2007; 102 (6): 2090–2091. 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