ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2019-3-134-143ssmu-2411Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESМитохондриальная ДНК как кандидатный DAMP при критических состоянияхMitochondrial DNA as DAMP in critical conditionshttps://orcid.org/0000-0002-3898-0740ГригорьевЕ. В.GrigorievE. V.

д-р мед. наук, профессор, зам. директора по научной и лечебной работе, вед. науч. сотрудник, 650002, г. Кемерово, Сосновый бульвар, 6;

зав. кафедрой анестезиологии и реаниматологии, 650000, г. Кемерово, ул. Ворошилова, 22а

DM, Professor, Deputy Director for Scientific and Clinical Affairs, 6, Sosnoviy Blvd, Kemerovo, 650002;

Head of the Department of Anesthesiology and Critical Care, 22a, Voroshilov Str., Kemerovo, 650000

grigorievev@hotmail.comhttps://orcid.org/0000-0002-9789-9555СалаховР. Р.SalakhovR. R.

канд. мед. наук, науч. сотрудник, лаборатория популяционной генетики, 

634050, г. Томск, ул. Набережная реки Ушайки, 10

PhD, Researcher, Laboratory of Population Genetics, 

10, Naberezhnaya Ushaiki Str., Tomsk, 634050

https://orcid.org/0000-0002-7692-9954ГолубенкоМ. В.GolubenkoM. V.

канд. биол. наук, ст. науч. сотрудник, лаборатория популяционной генетики, 650002, г. Кемерово, Сосновый бульвар, 6;

вед. науч. сотрудник, лаборатория геномной медицины, 634050, г. Томск, ул. Набережная реки Ушайки, 10

Leading Researcher, Laboratory for Genomic Medicine, 6, Sosnoviy Blvd, Kemerovo, 650002;

PhD, Senior Researcher, Laboratory of Population Genetics, 10, Naberezhnaya Ushaiki Str., Tomsk, 634050

https://orcid.org/0000-0002-3002-2863ПонасенкоА. В.PonasenkoA. V.

канд. мед. наук, зав. лабораторией геномной медицины,

650002, г. Кемерово, Сосновый бульвар, 6

PhD, Head of the Laboratory for Genomic Medicine, 

6, Sosnoviy Blvd, Kemerovo, 650002

https://orcid.org/0000-0001-5708-2463ШукевичД. Л.ShukevichD. L.

д-р мед. наук, зав. лабораторией критических состояний, профессор, 650002, г. Кемерово, Сосновый бульвар, 6;

кафедра анестезиологии и реаниматологии, 650000, г. Кемерово, ул. Ворошилова, 22а

DM, Head of the Laboratory for Critical Care, 6, Sosnoviy Blvd, Kemerovo, 650002;

Professor, Department of Anaesthesiology and Critical Care, 22a, Voroshilov Str., Kemerovo, 650000

https://orcid.org/0000-0002-4146-3373МатвееваВ. Г.MatveevaV. G.

канд. мед. наук, ст. науч. сотрудник, лаборатория клеточных технологий,

650002, г. Кемерово, Сосновый бульвар, 6

PhD, Senior Researcher, Laboratory for Cell Technologies,

6, Sosnoviy Blvd, Kemerovo, 650002

https://orcid.org/0000-0001-8743-4466РадивилкоА. С.RadivilkoA. S.

канд. мед. наук, ст. науч. сотрудник, лаборатория критических состояний,

650002, г. Кемерово, Сосновый бульвар, 6

PhD, Senior Researcher, Laboratory for Critical Care,

6, Sosnoviy Blvd, Kemerovo, 650002

https://orcid.org/0000-0002-4467-8732ЦепокинаА. В.TsepokinaA. V.

науч. сотрудник, лаборатория геномной медицины,

650002, г. Кемерово, Сосновый бульвар, 6

Researcher, Laboratory for Genomic Medicine,

6, Sosnoviy Blvd, Kemerovo, 650002

https://orcid.org/0000-0002-1079-1956ВеликановаЕ. А.VelikanovaE. A.

канд. биол. наук, науч. сотрудник, лаборатория клеточных технологий,

650002, г. Кемерово, Сосновый бульвар, 6

PhD, Researcher, Laboratory for Cell Technologies,

6, Sosnoviy Blvd, Kemerovo, 650002

https://orcid.org/0000-0002-2654-2727КорнелюкР. А.KornelyukR. S.

лаборант-исследователь, лаборатория критических состояний, 650002, г. Кемерово, Сосновый бульвар, 6;

ассистент, кафедра анестезиологии и реаниматологии, 650000, г. Кемерово, ул. Ворошилова, 22а

Researcher, Laboratory for Critical Care, 6, Sosnoviy Blvd, Kemerovo, 650002;

Assistant, Department of Anaesthesiology and Critical Care, 22a, Voroshilov Str., Kemerovo, 650000

https://orcid.org/0000-0002-3899-1642ИвкинА. А.IvkinA. S.

лаборант-исследователь, лаборатория критических состояний, 650002, г. Кемерово, Сосновый бульвар, 6;

клинический ординатор, кафедра анестезиологии и реаниматологии, 650000, г. Кемерово, ул. Ворошилова, 22а

Researcher, Laboratory for Genomic Medicine, 6, Sosnoviy Blvd, Kemerovo, 650002;

Resident, Department of Anaesthesiology and Critical Care, 22a, Voroshilov Str., Kemerovo, 650000

Научно-исследовательский институт (НИИ) комплексных проблем сердечно-сосудистых заболеваний; Кемеровский государственный медицинский университет (КГМУ)РоссияFederal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases; Kemerovo State Medical University (KSMU)Russian FederationНаучно-исследовательский институт (НИИ) медицинской генетики, Томский национальный исследовательский медицинский центр (НИМЦ) Российской академии наукРоссияResearch Institute of Medical Genetics, Tomsk National Research Medical Center (NRMC) of the Russian Academy of SciencesRussian FederationНаучно-исследовательский институт (НИИ) комплексных проблем сердечно-сосудистых заболеваний; Научно-исследовательский институт (НИИ) медицинской генетики, Томский национальный исследовательский медицинский центр (НИМЦ) Российской академии наукРоссияFederal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases; Research Institute of Medical Genetics, Tomsk National Research Medical Center (NRMC) of the Russian Academy of SciencesRussian FederationНаучно-исследовательский институт (НИИ) комплексных проблем сердечно-сосудистых заболеванийРоссияFederal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular DiseasesRussian Federation201927102019183134143Copyright © Григорьев Е.В., Салахов Р.Р., Голубенко М.В., Понасенко А.В., Шукевич Д.Л., Матвеева В.Г., Радивилко А.С., Цепокина А.В., Великанова Е.А., Корнелюк Р.А., Ивкин А.А., 20192019Григорьев Е.В., Салахов Р.Р., Голубенко М.В., Понасенко А.В., Шукевич Д.Л., Матвеева В.Г., Радивилко А.С., Цепокина А.В., Великанова Е.А., Корнелюк Р.А., Ивкин А.А.Grigoriev E.V., Salakhov R.R., Golubenko M.V., Ponasenko A.V., Shukevich D.L., Matveeva V.G., Radivilko A.S., Tsepokina A.V., Velikanova E.A., Kornelyuk R.S., Ivkin A.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/2411

Недавно открытая роль митохондрий и митохондриальной ДНК в развитии иммунного ответа находится в фокусе внимания современных исследований. Растет число доказательств того, что митохондриальная ДНК, сохранившая некоторые характеристики генома древних α-протеобактерий, является иммунным стимулом для воспалительных реакций. Системный воспалительный ответ является частым осложнением при оперативных вмешательствах и различных травмах, и причины его развития не могут быть объяснены обычными подходами. В обзоре представлена информация о современном понимании механизмов развития воспаления, опосредованного мтДНК, в том числе системного воспалительного ответа, а также о факторах, регулирующих гомеостаз митохондрий и высвобождение мтДНК при различных патологических состояниях.

The focus of the researchers’ attention today includes the recently discovered role of mitochondria in the immune response. Increasing evidence shows that mitochondrial DNA, in retaining some of their characteristics of the ancient α-proteobacteria’s genome, is a potent immune stimulus for inflammatory reactions. Systemic inflammatory response is a frequent complication in surgical interventions and various traumas, and its development cannot be explained using common conceptions. This review provides information on the current understanding of the development of inflammation mediated by mtDNA, including systemic inflammatory response, and on the mechanisms regulating mitochondrial homeostasis and mtDNA release in various pathological conditions.

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The authors declare that there are no conflicts of interest present.