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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ssmu</journal-id><journal-title-group><journal-title xml:lang="ru">Бюллетень сибирской медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of Siberian Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-0363</issn><issn pub-type="epub">1819-3684</issn><publisher><publisher-name>Siberian State Medical University, the Ministry of Healthcare of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20538/1682-0363-2013-5-13-17</article-id><article-id custom-type="elpub" pub-id-type="custom">ssmu-247</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕЖДИСЦИПЛИНАРНЫЕ ФУНДАМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ В МЕДИЦИНЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NTERDISCIPLINARY BASIC RESEARCH IN MEDICINE</subject></subj-group></article-categories><title-group><article-title>АТИПИЧНЫЕ ФОРМЫ РАССЕЯННОГО СКЛЕРОЗА В ТОМСКОЙ</article-title><trans-title-group xml:lang="en"><trans-title>ATYPICAL FORMS OF MULTIPLE SCLEROSIS IN THE TOMSK REGION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алифирова</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Alifirova</surname><given-names>V. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук, профессор, зав. кафедрой неврологии и нейрохирургии</p></bio><email xlink:type="simple">ev.terskikh@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Титова</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Titova</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук, ассистент кафедры неврологии и нейрохирургии</p></bio><email xlink:type="simple">ev.terskikh@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Терских</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Terskikh</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Клинический ординатор кафедры неврологии и нейрохирургии</p></bio><email xlink:type="simple">ev.terskikh@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мусина</surname><given-names>Н. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Musina</surname><given-names>N. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук, доцент кафедры неврологии и нейрохирургии</p></bio><email xlink:type="simple">ev.terskikh@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Сибирский государственный медицинский университет, Томск</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Siberian State Medical University, Tomsk</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>28</day><month>10</month><year>2013</year></pub-date><volume>12</volume><issue>5</issue><fpage>13</fpage><lpage>17</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Алифирова В.М., Титова М.А., Терских Е.В., Мусина Н.Ф., 2013</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="ru">Алифирова В.М., Титова М.А., Терских Е.В., Мусина Н.Ф.</copyright-holder><copyright-holder xml:lang="en">Alifirova V.M., Titova M.A., Terskikh E.V., Musina N.F.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://bulletin.ssmu.ru/jour/article/view/247">https://bulletin.ssmu.ru/jour/article/view/247</self-uri><abstract><p>Обследовано 280 пациентов в возрасте от 10 до 70 лет с достоверным диагнозом «рассеянный склероз» (РС) согласно критериям Мак-Доналда. Среди них у 6 (2,1%) больных заболевание впервые  проявило себя в возрасте старше 45; у 18 (6,4%) – ранее 20 лет. У 7 (2,5%) больных диагностировано злокачественное течение РС; у 30 (10,7%) – мягкое течение. </p></abstract><trans-abstract xml:lang="en"><p>The study involved 280 patients aged 10 to 70 years old with a valid diagnosis of multiple sclerosis according to the McDonald criteria. There  are 6 (2.1%) patients had the first manifestation of disease overthe age of 45, 18 (6.4%) – 20 years earlier. In 7 (2.5%) of patients diagnosed with malignant progressof the MS, in 30 (10.7%) – soft progress.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рассеянный склероз</kwd><kwd>варианты течения</kwd><kwd>атипичные формы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>multiple sclerosis</kwd><kwd>variants of the course</kwd><kwd>atypical forms</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Шмидт Т.Е., Яхно Н.Н. Рассеянный склероз: руководство для врачей. М.: МЕДпресс-информ, 2010. 272 с.</mixed-citation><mixed-citation xml:lang="en">Schmidt T.Ye., Yakhno N.N. Multiple sclerosis: a guide for physicians. Moscow, MEDpress-Inform Publ., 2010. 272 p. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">McDonald W.I., Comston A., Edan G. et al. 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