ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2013-5-39-45ssmu-251Research ArticleМЕЖДИСЦИПЛИНАРНЫЕ ФУНДАМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ В МЕДИЦИНЕNTERDISCIPLINARY BASIC RESEARCH IN MEDICINEКЛИНИЧЕСКОЕ, НЕЙРОФИЗИОЛОГИЧЕСКОЕ И ИММУНОЛОГИЧЕСКОЕ ОБСЛЕДОВАНИЕ ОНКОЛОГИЧЕСКИХ ПАЦИЕНТОВ С ПОРАЖЕНИЕМ ПЕРИФЕРИЧЕСКИХ НЕРВОВCLINICAL, NEUROPHYSIOLOGICAL AND IMMUNOLOGICAL STUDIES OF CANCER PATIENTS WITH LESIONS OF THE PERIPHERAL NERVESКоролёваЕ. С.KorolyovaYe. S.

Королёва Екатерина Сергеевна – аспирант кафедры неврологии и нейрохирургии

kattorina@list.ruАлифироваВ. М.AlifirovaV. M.

Алифирова Валентина Михайловна – доктор медицинских наук, профессор, зав. кафедрой неврологии и нейрохирургии

kattorina@list.ruГольдбергВ. Е.GoldbergV. Ye.

Гольдберг Виктор Евгеньевич – заслуженный деятель науки РФ, доктор медицинских наук, профессор, руководитель отделения химиотерапии

kattorina@list.ruНовиковаН. С.NovikovaN. S.

Новикова Наталья Сергеевна – кандидат медицинских наук, ассистент кафедры неврологии и нейрохирургии

kattorina@list.ruЖуковаИ. А.ZhukovaI. A.

Жукова Ирина Александровна – кандидат медицинских наук, доцент кафедры неврологии и нейрохирургии

kattorina@list.ruСибирский государственный медицинский университет, ТомскРоссияSiberian State Medical University, TomskRussian FederationНИИ онкологии СО РАМН, ТомскРоссияInstitute of oncology SB RAMS, TomskRussian Federation2013281020131253945Copyright © Королёва Е.С., Алифирова В.М., Гольдберг В.Е., Новикова Н.С., Жукова И.А., 20132013Королёва Е.С., Алифирова В.М., Гольдберг В.Е., Новикова Н.С., Жукова И.А.Korolyova Y.S., Alifirova V.M., Goldberg V.Y., Novikova N.S., Zhukova I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/251

Клиническое, электрофизиологическое и иммунологическое обследование 88 онкологических больных показало, что при раке молочной железы и мелкоклеточном раке легкого имеет место симметричная, дистальная, сенсорно-моторная, аксонально-демиелинизирующая полиневропатия. Аутоиммунную природу заболевания подтверждают онконевральные антитела, обнаруженные в сыворотке крови половины участников исследования. 

Clinical electrophysiological and immunological studies of 88 cancer patients showed that in breast cancer and small lung cancer takes place symmetric, distal, sensory-motor, axonal-demyelinating polyneuropathy. Autoimmune nature of the disease confirmed onconeural antigens detected in the serum of more than half of the study participants. 

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The authors declare that there are no conflicts of interest present.