ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2013-2-266-274ssmu-254Research ArticleНА ПУТИ К БИОУПРАВЛЕНИЮОБОБЩЕННАЯ МОДЕЛЬ ТРЕХ ПРОЦЕССОВ ЦИКЛИЧЕСКОЙ РЕГУЛЯЦИИ СНА-БОДРСТВОВАНИЯA GENERAL MODEL FOR UNIFICATION OF THE THREE PROCESSES OF SLEEP-WAKE REGULATIONПутиловА. А.PutilovA. A.

Путилов Аркадий Александрович – доктор биологических наук, главыйнаучный сотрудник лаборатории математического моделирования биомедицинских систем

Putilov Arkady A. - Laboratory of Mathematical Modeling of Biomedical Systems

ewer@ngs.ruВеревкинЕ. Г.VerevkinYe. G.

Веревкин Евгений Георгиевич –  кандидат биологических наук, руководитель лаборатории математического моделирования биомедицинских систем

Verevkin Yevgeny G. - Laboratory of Mathematical Modeling of Biomedical Systems

ewer@ngs.ruНаучно-исследовательский институт молекулярной биологии и биофизики Сибирского отделения РАМН, НовосибирскРоссияInstitute of Molecular Biology and Biophysics SB RAMS, NovosibirskRussian Federation201328042013122266274Copyright © Путилов А.А., Веревкин Е.Г., 20132013Путилов А.А., Веревкин Е.Г.Putilov A.A., Verevkin Y.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/254

Самая известная модель цикла «сон-бодрствование» включает три различные формулы для описания динамики трех регуляторных процессов – гомеостатического, циркадианного и ультрадианного. Предложена модель, позволяющая применять одну простую формулу для описания всех трех процессов. Электроэнцефалографические записи обычного ночного сна были использованы для определения параметров модели и предсказания эффектов экспериментальных манипуляций режимом сна-бодрствования.

The most-known model of sleep-wake regulation includes different formulae describing the kinetics of three separate processes, i.e., homeostatic, circadian, and ultradian. We tried to explain all these processes within a more parsimonious modeling framework and to use the EEG recordings of baseline night sleep for derivation of the model’s parameters and for prediction of the effects of experimental manipulations with sleep-wake regimen.

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The authors declare that there are no conflicts of interest present.