ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2013-2-275-283ssmu-255Research ArticleНА ПУТИ К БИОУПРАВЛЕНИЮПРОГРАММИРОВАНИЕ ГЕНОВ МОЗГА И ПРОБЛЕМА СОЦИАЛЬНОГО ПОВЕДЕНИЯ ЧЕЛОВЕКАPROGRAMMING GENES IN BRAIN AND PROBLEM OF SOCIAL BEHAVIOR ОF MANФуксБ. Б.FuksB. B.

Фукс Борис Борисович – заслуженный деятель науки РФ,  доктор медицинских наук, профессор

borisberel@hotmail.comEnzyme Inc., БостонСоединённые Штаты АмерикиEnzyme Inc., BostonUnited States201328042013122275283Copyright © Фукс Б.Б., 20132013Фукс Б.Б.Fuks B.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/255

Факторы транскрипции программируют гены нейронов. Синтезируемые белки формируют долговременную память. Два гена рецептора гормона вазопрессина – гены альтруизма/эгоизма и один ген рецептора окситоцина определяют social recognition, memory and behavior. Люди делятся на три группы: гомозиготные альтруисты, эгоисты и гетерозиготную группу, содержащую оба гена альтруизма/эгоизма. Программирование генов поведения в этой группе происходит в течение первых двух недель жизни. Неблагоприятное программирование масс людей в этой группе могло быть причиной социальных катастроф ХХ в.

Transcription factors programmed genes of brain cells. Then proteins synthesized form long term memory. Two genes of hormone vasopressin receptor – genes of altruism / selfishnessand one oxytocin receptor gene provide social recognition, memory and behavior. Human population divided into three groups: homozygous altruists, homozygous egoists and heterozygous group containing both vasopressin genes. Behavior genes programming in the last group occurs within the first two weeks of life. Negative programming of masses of people in this group could be the cause of social disasters in the twentieth century.

факторы транскрипциивазопрессинокситоцинпрограммирование геновtranscription factorsvasopressinoxytocinprogramming geneReferencesБерель Б. Откровения Библии и молекулярная генетика альтруизма. СПб.: Ретро, 2010. 239 с.Berel B. The revelation of the Bible and molecular genetics altruism. St. Petersburg, Retro Publ., 2010. 239 p. (in Russian).Лаверычева И.Г. Философские и естественно-научные основания теории эгоизма и альтруизма. Саарбрюккен (Германия): LAP LAMBERT Academic Publishing, 2011. 270 c.Laverycheva I.G. Philosophical and scientific basis of the theory of egoism and altruism. LAP Lambert Academic Publishing, 2011. 270 c. (in Russian).Alberini C.M. Transcription Factors in Long-Term Memory and Synaptic Plasticity // Pysiol. Rev. 2009. V. 89, № 11. P. 21–145.Alberini C.M. Transcription Factors in Long-Term Memory and Synaptic Plasticity. Pysiol. Rev., 2009, vol. 89, no. 11, pp. 21–145.Apicella С.L., Cesarini D. Johannesson M. et al. No association between oxytocin receptor (OXTR) gene polymorphisms and experimentally elicited social preferences // 2010: PLoS Jun 16. 5(6): e11153.Apicella С.L., Cesarini D. Johannesson M. et al. No association between oxytocin receptor (OXTR) gene polymorphisms and experimentally elicited social preferences. 2010. PLoS Jun 16. 5(6): e11153.De Dreu C.K.W. Oxytocin modulates cooperation within and competition between groups: an integrative review and research agenda // Hormones and Behavior. 2012. 61. Р. 419–428.De Dreu C.K.W. Oxytocin modulates cooperation within and competition between groups: an integrative review and research agenda. Hormones and Behavior, 2012, 61, pp. 419–428.Ebstein R., Knafo А., Mankuta D. et al. The contributions of oxytocin and vasopressin pathway genes to human behavior // Hormones and Behavior. 2012. 61. Р. 359–379.Ebstein R., Knafo А., Mankuta D. et al. The contributions of oxytocin and vasopressin pathway genes to human behavior. Hormones and Behavior, 2012, 61, pp. 359–379.Gabor C.S., Phan A., Choleris E., Kavaliers M. et al. Interplay of oxytocin, vasopressin and sex hormones in the regulation of social recognition // Behavioral Neuroscience. 2012. V. 126, № 1. Р. 97–109.Gabor C.S., Phan A., Choleris E., Kavaliers M. et al. Interplay of oxytocin, vasopressin and sex hormones in the regulation of social recognition. Behavioral Neuroscience, 2012, vol. 126, no. 1, pp. 97–109.Guzowski J.F., McGaugh J.L. Antisense oligodeoxynucleotidemediated disruption of hippocampal cAMP response element binding protein levels impairs consolidation of memory for water maze training // Proc. Natl. Acad. Sci. USA. 1997. 18. 94 (6). Р. 2693–2698.Guzowski J.F., McGaugh J.L. Antisense oligodeoxynucleotidemediated disruption of hippocampal cAMP response element binding protein levels impairs consolidation of memory for water maze training. Proc. Natl. Acad. Sci. USA, 1997, 18, 94(6), pp. 2693–2698.Knafo A., Israel S., Darvasi A. et al. Individual differences in allocation of funds in the dictator game associated with length of the arginine vasopressin 1a receptor RS3 promoter region and correlation between RS3 length and hippocampal mRNA // Genes Brain Behav. 2008. 7. Р. 266–275.Knafo A., Israel S., Darvasi A. et al. Individual differences in allocation of funds in the dictator game associated with length of the arginine vasopressin 1a receptor RS3 promoter region and correlation between RS3 length and hippocampal mRNA. Genes Brain Behav., 2008, 7, pp. 266–275.Loup F., Tribollet E., Dubois-Dauphin M., Dreifuss J.J. Localization of high-affinity binding sites for oxytocin and vasopressin in the human brain. An autoradiographic study // Brain Res. 1991. Aug. 2. 555 (2). Р. 220–232.Loup F., Tribollet E., Dubois-Dauphin M., Dreifuss J.J. Localization of high-affinity binding sites for oxytocin and vasopressin in the human brain. An autoradiographic study. Brain Res., 1991, Aug. 2, 555 (2), pp. 220–232.Veenema A.H. Toward understanding how early-life experiences alter oxytocinand vasopressin-regulated social behaviors // Hormones and Behavior. 2012. 61. Р. 304–312.Veenema A.H. Toward understanding how early-life experiences alter oxytocinand vasopressin-regulated social behaviors. Hormones and Behavior, 2012, 61, pp. 304–312.Young L.J., Huot B., Nilsen R. et al. Species Differences in Central Oxytocin Gene Expression: Comparative Analysis of Promoter Sequenses // J. of Neuroendocrin. 1996. V. 8. P. 777–783.Young L.J., Huot B., Nilsen R. et al. Species Differences in Central Oxytocin Gene Expression: Comparative Analysis of Promoter Sequenses. J. of Neuroendocrin., 1996, vol. 8, pp. 777–783.

The authors declare that there are no conflicts of interest present.