ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2019-4-256-265ssmu-2579Research ArticleСЛУЧАЙ ИЗ КЛИНИЧЕСКОЙ ПРАКТИКИCLINICAL CASESCLIPPERS. Обзор литературы и собственные наблюденияCLIPPERS. Three clinical cases and reviewhttps://orcid.org/0000-0002-4776-2999ПраховаЛ. Н.PrakhovaL. N.

д-р мед. наук, зав. лабораторией нейрореабилитации,

197376, г. Санкт-Петербург, ул. Академика Павлова, 9

DM, Head of the Neurorehabilitation Laboratory,

9, Akademika Pavlova Str., St. Petersburg, 197376

l.n.prakhova@hotmail.comПарфеноваА. С.ParfyonovaA. S.

клинический ординатор, отделение неврологии,

197376, г. Санкт-Петербург, ул. Академика Павлова, 9

Resident, Department of Neurology,

9, Akademika Pavlova Str., St. Petersburg, 197376

https://orcid.org/0000-0001-9306-2101СавинцеваЖ. И.SavintsevaZh. I.

канд. мед. наук, врач-рентгенолог, отделение лучевой диагностики, 

197376, г. Санкт-Петербург, ул. Академика Павлова, 9

PhD, Rentgenologist, Radiology Department,

9, Akademika Pavlova Str., St. Petersburg, 197376

ИльвесА. Г.IlvesA. G.

канд. мед. наук, ст. науч. сотрудник, лаборатория нейроиммунологии,

197376, г. Санкт-Петербург, ул. Академика Павлова, 9

PhD, Senior Researcher, Neuroimmunology Laboratory,

9, Akademika Pavlova Str., St. Petersburg, 197376

https://orcid.org/0000-0002-8193-0116БубноваЕ. В.BubnovaE. V.

канд. мед. наук, доцент, кафедра рентгенологии и радиационной медицины,

197022, г. Санкт-Петербург, ул. Льва Толстого, 6/8

PhD, Associate Professor,

6/8, Lva Tolstogo Str., St. Petersburg, 197022

https://orcid.org/0000-0002-9769-447XКрасновВ. С.KrasnovV. S.

канд. мед. наук, доцент, кафедра неврологии,

197022, г. Санкт-Петербург, ул. Льва Толстого, 6/8

PhD, Associate Professor, Department of Neurology,

6/8, Lva Tolstogo Str., St. Petersburg, 197022

https://orcid.org/0000-0002-2085-9205ТарасоваА. М.TarasovaA. M.

врач-невролог, неврологическое отделение № 1,

197022, г. Санкт-Петербург, ул. Льва Толстого, 6/8

Neurologist,

6/8, Lva Tolstogo Str., St. Petersburg, 197022

https://orcid.org/0000-0002-6715-8203ТотолянН. А.TotolyanN. A.

д-р мед. наук, профессор, кафедра неврологии,

197022, г. Санкт-Петербург, ул. Льва Толстого, 6/8

DM, Professor, Department of Neurology,

6/8, Lva Tolstogo Str., St. Petersburg, 197022

Институт мозга человека (ИМЧ) им. Н.П. Бехтеревой Российской академии наук (РАН)РоссияN.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences (RAS)Russian FederationПервый Санкт-Петербургский государственный медицинский университет им. И.П. Павлова (ПСПБГМУ)РоссияAcademician I.P. Pavlov First St. Petersburg State Medical UniversityRussian Federation201914012020184256265Copyright © Прахова Л.Н., Парфенова А.С., Савинцева Ж.И., Ильвес А.Г., Бубнова Е.В., Краснов В.С., Тарасова А.М., Тотолян Н.А., 20202020Прахова Л.Н., Парфенова А.С., Савинцева Ж.И., Ильвес А.Г., Бубнова Е.В., Краснов В.С., Тарасова А.М., Тотолян Н.А.Prakhova L.N., Parfyonova A.S., Savintseva Z.I., Ilves A.G., Bubnova E.V., Krasnov V.S., Tarasova A.M., Totolyan N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/2579

CLIPPERS (Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids) is a rare inflammatory disease of the central nervous system, during which the pons of the brain is damaged. This disease was described for the first time in 2010 by S.J. Pittock et.al. At present, there have been around 50 described cases of the disease. Up to the present moment, there are difficulties diagnosing this disease. In the article, a literature review and three clinical cases are presented. Furthermore, the necessity of further research is shown for improving the accuracy and specificity of the diagnostic criteria, as well as for defining biomarkers and developing algorithms of effective therapy.

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The authors declare that there are no conflicts of interest present.