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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ssmu</journal-id><journal-title-group><journal-title xml:lang="ru">Бюллетень сибирской медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of Siberian Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-0363</issn><issn pub-type="epub">1819-3684</issn><publisher><publisher-name>Siberian State Medical University, the Ministry of Healthcare of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20538/1682-0363-2020-3-137-143</article-id><article-id custom-type="elpub" pub-id-type="custom">ssmu-2998</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ И ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW AND LECTURES</subject></subj-group></article-categories><title-group><article-title>Аллергический ринит и феномен энтопии</article-title><trans-title-group xml:lang="en"><trans-title>Allergic rhinitis and the phenomenon of entopy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Климов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Klimov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, ассистент, кафедра оториноларингологии</p><p>Россия, 634050, г. Toмск, Московский тракт, 2</p></bio><bio xml:lang="en"><p>2, Moscow Тrаkt, Tomsk, 634050, Russian Federation</p></bio><email xlink:type="simple">klimov.lor@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Kaлюжин</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kalyughin</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, профессор, кафедра клинической иммунологии и аллергологии</p><p>Россия, 119991, г. Moсква, ул. Трубецкая, 8/2</p></bio><bio xml:lang="en"><p>8/2, Trubetskaya Str., Moscow, 119991, Russian Federation</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Kлимов</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Klimov</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, профессор, зав. кафедрой иммунологии и аллергологии</p><p>Россия, 634050, г. Toмск, Московский тракт, 2</p></bio><bio xml:lang="en"><p>2, Moscow Тrаkt, Tomsk, 634050, Russian Federation</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Свиридова</surname><given-names>В. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Sviridova</surname><given-names>V. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, доцент, кафедра иммунологии и аллергологии</p><p>Россия, 634050, г. Toмск, Московский тракт, 2</p></bio><bio xml:lang="en"><p>2, Moscow Тrаkt, Tomsk, 634050, Russian Federation</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Сибирский государственный медицинский университет (СибГМУ)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Siberian State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Первый Московский медицинский государственный университет им. И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>07</day><month>10</month><year>2020</year></pub-date><volume>19</volume><issue>3</issue><fpage>137</fpage><lpage>143</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Климов А.В., Kaлюжин О.В., Kлимов В.В., Свиридова В.С., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Климов А.В., Kaлюжин О.В., Kлимов В.В., Свиридова В.С.</copyright-holder><copyright-holder xml:lang="en">Klimov A.V., Kalyughin O.V., Klimov V.V., Sviridova V.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://bulletin.ssmu.ru/jour/article/view/2998">https://bulletin.ssmu.ru/jour/article/view/2998</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>aллергены</kwd><kwd>aтопия</kwd><kwd>энтопия</kwd><kwd>толерантность к аллергенам</kwd><kwd>aллергический ринит</kwd><kwd>локальный аллергический ринит</kwd><kwd>фенотипы</kwd><kwd>эндотипы</kwd><kwd>биомаркеры</kwd><kwd>Т-хелперы 2-го типа</kwd><kwd>T-регуляторные клетки</kwd></kwd-group><kwd-group xml:lang="en"><kwd>allergens</kwd><kwd>atopy</kwd><kwd>entopy</kwd><kwd>allergen tolerance</kwd><kwd>allergic rhinitis</kwd><kwd>local allergic rhinitis</kwd><kwd>phenotypes</kwd><kwd>endotypes</kwd><kwd>biomarkers</kwd><kwd>type 2 helper T cells</kwd><kwd>T regulatory cells</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Coca A.F., Cooke R.A. 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