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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ssmu</journal-id><journal-title-group><journal-title xml:lang="ru">Бюллетень сибирской медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of Siberian Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-0363</issn><issn pub-type="epub">1819-3684</issn><publisher><publisher-name>Siberian State Medical University, the Ministry of Healthcare of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20538/1682-0363-2006-1-38-45</article-id><article-id custom-type="elpub" pub-id-type="custom">ssmu-3040</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЭКСПЕРИМЕНТАЛЬНЫЕ И КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>EXPERIMENTAL AND CLINICAL INVESTIGATIONS</subject></subj-group></article-categories><title-group><article-title>Структурная неоднородность левого желудочка и ремоделирование миокарда</article-title><trans-title-group xml:lang="en"><trans-title>Left ventricular structural heterogeneity and myocardial remodelling</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Найдич</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Naidich</surname><given-names>A. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Уральский государственный университет им. А.М. Горького; &#13;
НИИ трансплантологии и искусственных органов</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2006</year></pub-date><pub-date pub-type="epub"><day>30</day><month>03</month><year>2006</year></pub-date><volume>5</volume><issue>1</issue><fpage>38</fpage><lpage>45</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Найдич А.М., 2006</copyright-statement><copyright-year>2006</copyright-year><copyright-holder xml:lang="ru">Найдич А.М.</copyright-holder><copyright-holder xml:lang="en">Naidich A.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://bulletin.ssmu.ru/jour/article/view/3040">https://bulletin.ssmu.ru/jour/article/view/3040</self-uri><abstract><p>С целью изучения взаимосвязи между структурной неоднородностью левого желудочка (ЛЖ) и ремоделированием миокарда была обследована группа лиц с ишемической болезнью сердца (ИБС) различной степени тяжести. На основе трехмерной реконструкции ЛЖ с использованием оригинальных методов обработки и анализа данных чреспищеводного ультразвукового обследования пациентов были вычислены стандартные параметры ремоделирования миокарда (средние значения толщины стенки и радиуса по короткой оси ЛЖ, соотношение длинной и короткой полуосей, объем камеры, масса миокарда и ее соотношение с толщиной стенки). Оценка неоднородности структуры в регионах ЛЖ была проведена с пространственным разрешением 4 × 4 мм с использованием параметров, характеризующих степень неодинаковости толщины и кривизны сердечной стенки, а также масштаб замещения сократительного материала соединительной тканью. Корреляционный анализ между показателями ремоделирования миокарда и структурной неоднородности ЛЖ выявил наличие тесной связи между исследуемыми явлениями в сердце. Оказалось, что чем выше степень ремоделирования миокарда, тем ниже неоднородность ЛЖ. Это означает, что процесс ремоделирования миокарда на фоне прогрессирующего течения ИБС развивается в направлении снижения масштаба структурной неоднородности ЛЖ. Сформулирована гипотеза, что в нормальном сердце неоднородность создает структурный базис для ремоделирования миокарда.</p></abstract><trans-abstract xml:lang="en"><p>Aimed at studying interrelation between left ventricular (LV) structural heterogeneity and myocardial remodeling, we exa- mined a group pf subjects having coronary artery disease (CAD) of several severity degree. Based on three-dimensional reconstruc-tion of LV and using original analysis methods of esophageal ultrasound investigation data, standard parameters of myocardial re-modeling ( mean values of wall thickness and short axis LV radius, interrelations of long and short semi-axes, camera volume, myo-cardial mass and its relation to the wall thickness) were scored. The assessment of heterogeneity in LV regions was performed with space resolution 4x4 mm using parameters which are characteristic of heterogeneity of the wall thickness and curvature degree and also, scale of constitution of connective material by connective tissue. Correlation analysis performed between data of LV remodel-ing and its structural heterogeneity revealed strong correlation events studied in the heart. It proved that the higher myocardial re-modeling degree the lower heterogeneity of LV. It means that myocardial remodeling process in the setting of advancing CAD de-velops to decreased scale of LV structural heterogeneity. It is suggested that heterogeneity in normal heart serves as structural basis for myocardial remodeling.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>левый желудочек</kwd><kwd>миокард</kwd><kwd>ишемическая болезнь сердца</kwd></kwd-group><kwd-group xml:lang="en"><kwd>left ventricle</kwd><kwd>myocardium</kwd><kwd>coronary artery disease</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Агеев Ф.Е., Скворцов А.А., Мареев В.Ю., Беленков Ю.Н. Сердечная недостаточность на фоне ишемической болезни сердца: некоторые вопросы эпидемиологии, патогенеза и лечения // Рус. мед. журн. 2000. № 15-16. С. 622-626.</mixed-citation><mixed-citation xml:lang="en">Агеев Ф.Е., Скворцов А.А., Мареев В.Ю., Беленков Ю.Н. Сердечная недостаточность на фоне ишемической болезни сердца: некоторые вопросы эпидемиологии, патогенеза и лечения // Рус. мед. журн. 2000. № 15-16. 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