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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ssmu</journal-id><journal-title-group><journal-title xml:lang="ru">Бюллетень сибирской медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of Siberian Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-0363</issn><issn pub-type="epub">1819-3684</issn><publisher><publisher-name>Siberian State Medical University, the Ministry of Healthcare of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20538/1682-0363-2014-2-66-73</article-id><article-id custom-type="elpub" pub-id-type="custom">ssmu-32</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LITERATURE REVIEW</subject></subj-group></article-categories><title-group><article-title>СТРУКТУРНО-ФУНКЦИОНАЛЬНЫЕ НАРУШЕНИЯ ЩИТОВИДНОЙ ЖЕЛЕЗЫ ПРИ РАЗЛИЧНЫХ ВИДАХ ЛЕЧЕНИЯ РАКА ГОРТАНИ</article-title><trans-title-group xml:lang="en"><trans-title>STRUCTURAL AND FUNCTIONAL DISORDERS OF THE THYROID GLAND IN DIFFERENT TYPES OF LARYNGEAL CANCER TREATMENT</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ворожцова</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Vorozhtsova</surname><given-names>I. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ворожцова Ирина Николаевна, доктор медицинских наук, профессор, зав. кафедрой эндокринологии и диабетологии</p></bio><bio xml:lang="en"/><email xlink:type="simple">m.cherks@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мухамедов</surname><given-names>М. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Mukhamedov</surname><given-names>M. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мухамедов Марат Рафкатович, доктор медицинских наук, ведущий научный сотрудник отделения опухолей головы и шеи</p></bio><bio xml:lang="en"/><email xlink:type="simple">m.cherks@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черкасова</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Cherkasova</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Черкасова Мария Александровна, аспирант кафедры эндокринологии и диабетологии</p></bio><bio xml:lang="en"/><email xlink:type="simple">m.cherks@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Латыпова</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Latypova</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Латыпова Венера Насхатовна, кандидат медицинских наук, доцент кафедры эндокринологии и диабетологии</p></bio><bio xml:lang="en"/><email xlink:type="simple">m.cherks@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Сибирский государственный медицинский университет, Томск</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Siberian State Medical University, Tomsk</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Научно-исследовательский институт онкологии Сибирского отделения РАМН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk,</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>28</day><month>04</month><year>2014</year></pub-date><volume>13</volume><issue>2</issue><fpage>66</fpage><lpage>73</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ворожцова И.Н., Мухамедов М.Р., Черкасова М.А., Латыпова В.Н., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Ворожцова И.Н., Мухамедов М.Р., Черкасова М.А., Латыпова В.Н.</copyright-holder><copyright-holder xml:lang="en">Vorozhtsova I.N., Mukhamedov M.R., Cherkasova M.A., Latypova V.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://bulletin.ssmu.ru/jour/article/view/32">https://bulletin.ssmu.ru/jour/article/view/32</self-uri><abstract><p>Щитовидная железа (ЩЖ) является важным эндокринным органом, оказывающим значимое воздействие как в перинатальном периоде, так и на протяжении всей жизни человека, участвуя в регуляции метаболизма. Наиболее частый вариант тиреоидной дисфункции – гипотиреоз, который влечет за собой нарушения в работе различных органов и систем, включая психоэмоциональную сферу. Это может усугублять течение сопутствующих заболеваний, в частности – онкологических процессов.Среди опухолей головы и шеи первое место по частоте встречаемости занимает рак гортани. Несмотря на доступность данной локализации для визуализирующих методов диагностики, более 50% случаев выявляются на III и IV стадиях, что влечет за собой необходимость проведения расширенных калечащих операций, которые приводят к нарушению или потере важнейших функций: дыхательной, глотательной, речевой, вызывая длительную или стойкую нетрудоспособность. Это делает рак гортани значимой медико-социальной и экономической проблемой.Одним из ведущих методов лечения рака гортани является дистанционная гамма-терапия на область шеи. При этом в зону облучения неизбежно попадает ЩЖ, которая может принимать на себя более 50% суммарной очаговой дозы. Наиболее частым исходом постлучевого воспаления является фиброз тиреоидной ткани вследствие поражения сосудистого русла и гибели тиреоцитов с развитием гипофункции ЩЖ, что влечет за собой усугубление стрессового состояния, вызванного онкологическим процессом и агрессивной противоопухолевой терапией, неблагоприятно влияет на течение постоперационного периода.Несмотря на то что диагностика гипофункции ЩЖ достаточно проста, а заместительная терапия L-тироксином доступна, многие врачи не проводят определение тиреоидного статуса у онкологических пациентов, либо включают в обследование не весь спектр необходимых показателей.Таким образом, чрезвычайно актуален вопрос своевременного выявления гипотиреоза при лечении рака гортани, что позволит в ранние сроки назначить адекватное лечение и снизить частоту осложнений.</p></abstract><trans-abstract xml:lang="en"><p>The thyroid gland is an important endocrine organ, which has a significant influence on human organism from the perinatal period and throughout the whole life, participating in the regulation of metabolism. The most common variant of thyroid dysfunction is hypothyroidism, which causes different disorders in various organs and systems, including psycho-emotional sphere. This can burden comorbidities and particularly malignant processes.Laryngeal cancer is the most common type of head and neck cancer. Despite the visual availability of this localization for diagnosis, more than 50% of cases stay timely unrecognized. Many cases are found out at stages III and IV, which requires expanded operations and causes traumatization because of disruption or loss of such important functions as breathing, swallowing, speech, causing long-term or permanent disability. This makes laryngeal cancer significant medical and social and economic problem.One of the leading treatments for cancer of the larynx is external beam radiotherapy. Thyroid gland gets into the radiation area and may take more than 50% of the total focal dose. The most common outcome of post-radiation inflammation is fibrosis of thyroid tissue due to lesions of the blood vessels and destruction of thyrocytes. It causes the development of hypothyroidism, which exacerbate stress caused by cancer and by aggressive antitumor therapy. Also, hypothyroidism adversely affects the patients’ condition during the postoperative period.Despite the fact that the diagnosis of hypothyroidism is pretty simple, and replacement therapy with L-thyroxine is cheap and available, many doctors don’t monitorthyroid function in cancer patients at all or don’t make all necessary tests.Thus, timely detection of hypothyroidism is extremely important during and after the treatment of laryngeal cancer. Early prescribing adequate treatment helps to reduce the incidence of complications.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рак гортани</kwd><kwd>щитовидная железа</kwd><kwd>гипотиреоз</kwd><kwd>гемитиреоидэктомия</kwd><kwd>лучевая терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>laryngeal cancer</kwd><kwd>thyroid gland</kwd><kwd>hypothyroidism</kwd><kwd>hemithyroidectomy</kwd><kwd>radiotherapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Эндокринология: руководство для врачей: в 2 т. / под ред. С.Б. Шустова. СПб.: СпецЛит, 2011. Т. 1. 400 с.</mixed-citation><mixed-citation xml:lang="en">Еndocrinology: guide for physicians: in 2 vol. Eds. S.B. Shustov. St. Petersburg, SpecLit Publ., 2011. Vol. 1. 400 p. 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