ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2013-6-144-153ssmu-324Research ArticleОБЗОР ЛИТЕРАТУРЫLITERATURE REVIEWНАРУШЕНИЯ МЕЖКЛЕТОЧНЫХ ВЗАИМОДЕЙСТВИЙ В ПАТОГЕНЕЗЕ ВОСПАЛЕНИЯ ЖИРОВОЙ ТКАНИ ПРИ МЕТАБОЛИЧЕСКОМ СИНДРОМЕDISORDER OF INTERCELLULAR CORRELATIONS IN PATHOGENESIS OF FATTY TISSUE INFLAMMATION IN METABOLIC SYNDROMEОсиховИ. А.OsikhovI. A.innadave@mail2000.ruБеспаловаИ. Д.BespalovaI. D.innadave@mail2000.ruБычковВ. А.BychkovV. A.innadave@mail2000.ruРязанцеваН. В.RyazantsevaN. V.innadave@mail2000.ruКалюжинВ. В.KalyuzhinV. V.

Доктор медицинских наук, профессор кафедры госпитальной терапии с курсом физической реабилитации и спортивной медицины

innadave@mail2000.ruАфанасьеваС. Д.AfanasyevaD. S.innadave@mail2000.ruМурашевБ. Ю.MurashevB. Yu.innadave@mail2000.ruСибирский государственный медицинский университет,. ТомскРоссияSiberian State Medical University, TomskRussian FederationСибирский государственный медицинский университет,. ТомскРоссияSiberian State Medical University, TomskRussian Federation201328122013126144153Copyright © Осихов И.А., Беспалова И.Д., Бычков В.А., Рязанцева Н.В., Калюжин В.В., Афанасьева С.Д., Мурашев Б.Ю., 20132013Осихов И.А., Беспалова И.Д., Бычков В.А., Рязанцева Н.В., Калюжин В.В., Афанасьева С.Д., Мурашев Б.Ю.Osikhov I.A., Bespalova I.D., Bychkov V.A., Ryazantseva N.V., Kalyuzhin V.V., Afanasyeva D.S., Murashev B.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/324

Ввиду того что в настоящее время остаются недостаточно ясными механизмы синтропии патологических состояний и нозологических единиц, объединенных рамками метаболического синдрома, в научном обзоре предпринята попытка обобщить данные о роли воспаления жировой ткани в патогенезе этого симптомокомплекса. Проанализированы результаты крупных зарубежных исследований последних лет, посвященных оценке провоспалительной активности адипоцитов и макрофагов жировой ткани, а также данные, касающиеся особенностей их взаимодействия при абдоминальном ожирении – основном компоненте метаболического синдрома. Изучение патогенеза воспаления жировой ткани с позиций оценки нарушений кооперации клеток позволит глубже понять клеточные и молекулярные механизмы этого процесса и открывает перспективы для разработки новых патогенетически обоснованных подходов к лечению метаболического синдрома

Due to the fact that nowadays mechanisms of syntropy of pathological conditions and nosological units, united within the metabolic syndrome, remain unclear, the scientific review attempts to summarize data on the role of fatty tissue inflammation in pathogenesis of this symptom complex. The results of recent major foreign studies on evaluation of pro-inflammatory activity of adipocytes and macrophages of the fatty tissue, as well as the data on peculiarities of their interactions in abdominal obesity, which is the main component of the metabolic syndrome, were analyzed. Studing pathogenesis of fatty tissue inflammation from the perspective of evaluation of disorders in cell cooperation will allow to more deeply understand cellular and molecular mechanisms of this process as well as open new avenues for developing new pathogenetically justified approaches to metabolic syndrome treatment.

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The authors declare that there are no conflicts of interest present.