ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2013-6-167-174ssmu-326Research ArticleОБЗОР ЛИТЕРАТУРЫLITERATURE REVIEWБЕЛКИ, ПЕПТИДЫ И АМИНОКИСЛОТЫ ВЫДЫХАЕМОГО ВОЗДУХА КАК МАРКЕРЫ БРОНХО-ЛЕГОЧНЫХ ЗАБОЛЕВАНИЙPROTEINS, PEPTIDES AND AMINO ACIDS AS MARKERS OF BRONCHOPULMONARY DISEASESФёдоровВ. И.FyodorovV. I.vif41@mail.ruКарапузиковА. А.KarapuzikovA. A.vif41@mail.ruСтариковаМ. К.StarikovaM. K.vif41@mail.ruСпециальные технологии, ООО, НовосибирскРоссияSpecial Technologies Ltd., NovosibirskRussian Federation201328122013126167174Copyright © Фёдоров В.И., Карапузиков А.А., Старикова М.К., 20132013Фёдоров В.И., Карапузиков А.А., Старикова М.К.Fyodorov V.I., Karapuzikov A.A., Starikova M.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/326

Представлен обзор современной литературы о содержании в выдыхаемом воздухе человека белков, пептидов и аминокислот. Описываются результаты применения методов протеомики и метаболомики для селективного детектирования отдельных белков, пептидов и аминокислот. Рассматриваются результаты исследования конденсата выдыхаемого воздуха и малых нелетучих эндогенных частиц. Описываются особенности содержания в выдыхаемом воздухе белков, пептидов и аминокислот при различных заболеваниях дыхательной системы. Показано, что обнаруживаемые вещества могут быть специфическими маркерами конкретных заболеваний.

The article is a review of current literature on a content of proteins, peptides and amino acids in human exhaled breath. The results of proteomics and metabolomics applying for selective detection of individual proteins, peptides and amino acids are described. The study of exhaled breath condensate and exhaled endogenous particles contained lung proteins are considered. The peculiarities of protein, peptide and amino acid content in exhaled breath at various respiratory diseases are described. It is shown that the detectable substances may be specific markers of individual diseases.

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The authors declare that there are no conflicts of interest present.