ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2013-3-5-17ssmu-333Research ArticleПЕРЕДОВАЯ СТАТЬЯEDITORIALМИТОХОНДРИАЛЬНЫЙ БЕЛКОВЫЙ ПРОФИЛЬ И ЕГО РОЛЬ В ПАТОЛОГИЧЕСКИХ ПРОЦЕССАХMITOCHONDRIAL PROTEIN PROFILE AND ITS ROLE IN PATHOLOGIC PROCESSESКостеринаЕ. А.KosterinaYe. A.mpatrushev@innopark.kantiana.ruКозенковИ. И.KozenkovI. I.

Младший научны сотрудник лаборатории геномных и протеомных исследований 

mpatrushev@innopark.kantiana.ruКасымовВ. А.KasymovV. A.mpatrushev@innopark.kantiana.ruКаменскийП. А.KamenskyP. A.

Кандидат биологических наук,  старший научный сотрудник лаборатории геномных и протеомных исследований 

mpatrushev@innopark.kantiana.ruДоминоваИ. Н.DominovaI. N.

Младший научныйсотрудник лаборатории геномных и протеомных исследований

mpatrushev@innopark.kantiana.ruКоролёваЮ. А.KorolyovaYu. A.

Младший научныйсотрудник лаборатории геномных и протеомных исследований

mpatrushev@innopark.kantiana.ruПатрушеваВ. Е.PatrushevaV. Ye.mpatrushev@innopark.kantiana.ruБогачевР. С.BogachevR. S.mpatrushev@innopark.kantiana.ruЛитвиноваЛ. С.LitvinovaL. S.mpatrushev@innopark.kantiana.ruБабакС. В.BabakS. V.mpatrushev@innopark.kantiana.ruМоисееваЕ. М.MoiseevaYe. M.mpatrushev@innopark.kantiana.ruБогдановЕ. А.BogdanovYe. A.mpatrushev@innopark.kantiana.ruМухортоваО. А.MukhortovaO. A.mpatrushev@innopark.kantiana.ruВавилинаЯ. С.VavilinaYa. S.mpatrushev@innopark.kantiana.ruМихальченковаТ. А.MikhalchenkovaT. A.mpatrushev@innopark.kantiana.ruПатрушевМ. В.PatrushevM. V.mpatrushev@innopark.kantiana.ruБалтийский федеральный университет имени И. Канта, КалининградРоссияImmanuel Kant Baltic Federal University, KaliningradRussian Federation201328062013123517Copyright © Костерина Е.А., Козенков И.И., Касымов В.А., Каменский П.А., Доминова И.Н., Королёва Ю.А., Патрушева В.Е., Богачев Р.С., Литвинова Л.С., Бабак С.В., Моисеева Е.М., Богданов Е.А., Мухортова О.А., Вавилина Я.С., Михальченкова Т.А., Патрушев М.В., 20132013Костерина Е.А., Козенков И.И., Касымов В.А., Каменский П.А., Доминова И.Н., Королёва Ю.А., Патрушева В.Е., Богачев Р.С., Литвинова Л.С., Бабак С.В., Моисеева Е.М., Богданов Е.А., Мухортова О.А., Вавилина Я.С., Михальченкова Т.А., Патрушев М.В.Kosterina Y.A., Kozenkov I.I., Kasymov V.A., Kamensky P.A., Dominova I.N., Korolyova Y.A., Patrusheva V.Y., Bogachev R.S., Litvinova L.S., Babak S.V., Moiseeva Y.M., Bogdanov Y.A., Mukhortova O.A., Vavilina Y.S., Mikhalchenkova T.A., Patrushev M.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/333

Собственная ДНК митохондрий кодирует лишь 13 полипептидов – субъединиц электронтранспортной цепи. Большинство же белков импортируются в митохондрии посредством различных механизмов. Последние исследования митохондриального протеома продемонстрировали истинные размеры и сложную функциональную организацию митохондриальных белковых профилей. Для протеомного профилирования митохондрий применяются различные технологии, которые в сумме представляют результаты, помогающие понять молекулярные механизмы функционирования органелл и выявить нарушения, приводящие к различным заболеваниям. В данном обзоре рассмотрены и проанализированны последние данные в области протеомики митохондрий и затронуты некоторые аспекты молекулярного патогенеза заболеваний дыхательной цепи.

Mitochondria import hundreds of different precursor proteins from the cytosol, and only 13 proteins are encoded by mtDNA itself. Recent investigations demonstrated real size of mitochondrial proteome and complexity of their functions There are many methods using for mitochondrial proteome profiling, that help to understand a molecular mechanisms of mitochondrial functions and identify the causes of disruptions that lead to different disorders. In this review we discuss a recent data in the field of mitochondrial proteomics.

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The authors declare that there are no conflicts of interest present.