Genotypes and haplotypes frequencies for VDR polymorphisms in case-control studies of multiple sclerosis (MS) were investigated. Results show an association of VDR T/t variant with diseases (p < 0,05). This marker was also associated with amount of eosinophils in MS patients (p < 0,05). Polymorphisms B/b and F/f was associated with ESR level, IgG level and amount of the CD16+ cell (p < 0,05). We demonstrate that the Bft haplotype significantly higher observed at MS patients and btT — at healthy person Received data allow suggests that the allele t VDR and Bft haplotype of VDR gene could increase susceptibility to MS and have influence on clinical manifestation of diseases.