ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2008-5-1-208-213ssmu-3477Research ArticleМАТЕРИАЛЫ 5-й МЕЖРЕГИОНАЛЬНОЙ НАУЧНО-ПРАКТИЧЕСКОЙ КОНФЕРЕНЦИИ «АКТУАЛЬНЫЕ ВОПРОСЫ НЕВРОЛОГИИ»Окислительный стресс — характерная особенность патогенеза рассеянного склерозаThe oxidative stress is typical peculiarity by multiple sclerosisКротенкоН. В.KrotenkoN. V.

г. Томск

АлифироваВ. М.AlifirovaV. M.

г. Томск

ИвановаС. А.IvanovaS. A.

г. Томск

Сибирский государственный медицинский университетRussian FederationНИИ психического здоровья ТНЦ СО РАМНRussian Federation20083012200875-1208213Copyright © Кротенко Н.В., Алифирова В.М., Иванова С.А., 20082008Кротенко Н.В., Алифирова В.М., Иванова С.А.Krotenko N.V., Alifirova V.M., Ivanova S.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/3477

The problem of pathogenesis of multiple sclerosis is of great importance in modern neurology and its solution allows to determine a pathogenetic approach to treatment of this severe disease. Complex clinical-biochemical investigation has been conducted in 79 patients with multiple sclerosis and 75 mentally and physically healthy persons. Parameters of intensification of lipid peroxidation and indices of the state of enzymatic and non-enzymatic patterns in antioxidant defense system in different clinical forms and at different stages of MS course have been analyzed. The data obtained confirm the presence of oxidant stress in the development of pathological process in MS.

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The authors declare that there are no conflicts of interest present.