Revealing the particularities of the ischemic stroke course in patients with different types of cardiac pathology, with disturbances of the rhythm first of all, can play the certain role in forecast and tactic of the treatment of this disease. Analysis of the clinical particularities of the cardioembolic stroke course, depending on infarction localizations and type accompanying heart pathology was made. Examination of 61 patients, with determination degree of stroke gravity using American Scale (NIH-NINDS) on 1-st, 3-d and 10-th day of the disease was performed. The positive correlation was revealed between patients age and cardioembolic stroke frequency, cardiac rhythm disturbances and primary localization of the ischemia in pool of the left middle cerebral artery. The permanent form of the precordial twinkling is the most disadvantage prognosis factor and associated with forming the more severe neurological deficit.