ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2005-4-78-83ssmu-3699Research ArticleНАУЧНЫЙ И УЧЕБНЫЙ ПРОЦЕСС: МЕТОДИЧЕСКИЙ СЕМИНАРSCIENTIFIC AND STUDYING PROCESS: METHODIC SEMINARВирусиндуцированная модуляция программы апоптотической гибели клеткиVirus-induced modulation of apoptotic cell death programЧечинаО. Е.ChechinaO. Ye.

Томск

ЖуковаО. Б.ZhoukovaO. B.

Томск

РязанцеваН. В.RyazantsevaN. V.

Томск

НовицкийВ. В.NovitskyV. V.

Томск

НасыроваР. Ф.NasyrovaR. F.

Томск

МихеевС. Л.MikheyevS. L.

Томск

ЛитвакМ. М.LitvakM. M.

Томск

Сибирский государственный медицинский университетRussian Federation200530122005447883Copyright © Чечина О.Е., Жукова О.Б., Рязанцева Н.В., Новицкий В.В., Насырова Р.Ф., Михеев С.Л., Литвак М.М., 20052005Чечина О.Е., Жукова О.Б., Рязанцева Н.В., Новицкий В.В., Насырова Р.Ф., Михеев С.Л., Литвак М.М.Chechina O.Y., Zhoukova O.B., Ryazantseva N.V., Novitsky V.V., Nasyrova R.F., Mikheyev S.L., Litvak M.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/3699

В статье представлены данные исследований отечественных и зарубежных авторов о наличии у вирусов разнообразных приспособительных механизмов, позволяющих им воздействовать на те или иные ключевые моменты процесса апоптоза. От вирусиндуцированной модуляции программированной гибели клетки зависит его цитопатическое действие, интенсивность и эффективность иммунных реакций, а значит, и клинические проявления инфекционного процесса. Вмешательство вирусов в программу апоптоза является основополагающим при формировании вирусной персистенции.

Data of native and foreign authors concerning presence of several adaptive mechanisms in viruses which allow them to influence on key moments of apoptosis process are presented in the paper. Viral destructive action, intensity and efficacy of immune reactions and hence clinical manifestations of infectious process depend on virus-induced modulation of programmed cellular death. Influence of viruses on the program of apoptosis is established to be the basic one in forming viral persistence.

апоптозвирусыперсистенциямодуляция апоптозаapoptosisvirusespersistencemodulation of apoptosisReferencesЖукова О.Б., Рязанцева Н.В., Новицкий В.В. Вирусная персистенция: иммунологические и молекулярно-генетические аспекты патогенеза//Бюл. сиб. медицины. 2003. № 4. С. 113-119.Жукова О.Б., Рязанцева Н.В., Новицкий В.В. Вирусная персистенция: иммунологические и молекулярно-генетические аспекты патогенеза//Бюл. сиб. медицины. 2003. № 4. С. 113-119.Жукова О.Б., Рязанцева Н.В., Новицкий В.В. и др. Модуляция апоптоза лимфоцитов крови как способ выживания вируса гепатита С//Иммунология. 2005. Т. 26. № 2. С. 79-83.Жукова О.Б., Рязанцева Н.В., Новицкий В.В. и др. Модуляция апоптоза лимфоцитов крови как способ выживания вируса гепатита С//Иммунология. 2005. Т. 26. № 2. С. 79-83.Рязанцева Н.В., Жукова О.Б., Новицкий В.В. и др. Роль иммунофенотипических и цитогенетических изменений лимфоцитов крови в механизмах хронизации вирусной инфекции//Эпидимиология и вакцинопрофилактика. 2003. № 6. С. 23-27.Рязанцева Н.В., Жукова О.Б., Новицкий В.В. и др. Роль иммунофенотипических и цитогенетических изменений лимфоцитов крови в механизмах хронизации вирусной инфекции//Эпидимиология и вакцинопрофилактика. 2003. № 6. С. 23-27.Рязанцева Н.В., Жукова О.Б., Новицкий В.В. и др. Структурные и функциональные особенности лимфоцитов у пациентов с хроническим носительством антигена вируса клещевого энцефалита//Бюл. эксперим. Биологии и медицины. 2002. № 11. С. 547-550.Рязанцева Н.В., Жукова О.Б., Новицкий В.В. и др. Структурные и функциональные особенности лимфоцитов у пациентов с хроническим носительством антигена вируса клещевого энцефалита//Бюл. эксперим. Биологии и медицины. 2002. № 11. С. 547-550.Рязанцева Н.В., Наследникова И.О., Зима А.П. и др. Молекулярные механизмы изменения продукции ФНО-α мононуклеарами крови при хроническом вирусном гепатите С//Бюл. эксперим. биологии и медицины. 2005. Т. 139. № 2. С. 191-195.Рязанцева Н.В., Наследникова И.О., Зима А.П. и др. Молекулярные механизмы изменения продукции ФНО-α мононуклеарами крови при хроническом вирусном гепатите С//Бюл. эксперим. биологии и медицины. 2005. Т. 139. № 2. С. 191-195.Рязанцева Н.В., Новицкий В.В., Жукова О.Б. и др. Программируемая клеточная гибель при персистентных вирусных инфекциях//Успехи физиол. наук. 2005. № 3. С. 33-44.Рязанцева Н.В., Новицкий В.В., Жукова О.Б. и др. Программируемая клеточная гибель при персистентных вирусных инфекциях//Успехи физиол. наук. 2005. № 3. С. 33-44.Новицкий В.В., Жукова О.Б., Рязанцева Н.В. и др. Цитогенетика лимфоцитов периферической крови при хронической персистенции вируса клещевого энцефалита//Бюл. СО РАМН. 2003. № 4. С. 34-37.Новицкий В.В., Жукова О.Б., Рязанцева Н.В. и др. Цитогенетика лимфоцитов периферической крови при хронической персистенции вируса клещевого энцефалита//Бюл. СО РАМН. 2003. № 4. С. 34-37.Ярилин А.А. Апоптоз. Природа феномена и его роль в целостном организме//Патолог, физиология и эксперим. терапия. 1998. № 2. С. 38-48.Ярилин А.А. Апоптоз. Природа феномена и его роль в целостном организме//Патолог, физиология и эксперим. терапия. 1998. № 2. С. 38-48.Barry М., McFadden G. Apoptosis regulators from DNA viruses//Current Opinion in Immunol. 1998. V. 10. P. 422-430.Barry М., McFadden G. Apoptosis regulators from DNA viruses//Current Opinion in Immunol. 1998. V. 10. P. 422-430.Chao D.T., Korsmeyer S.J. Bcl-2 family: regulators of cell death//Annual Review of Immunology. 1998. V. 16. P. 395-419.Chao D.T., Korsmeyer S.J. Bcl-2 family: regulators of cell death//Annual Review of Immunology. 1998. V. 16. P. 395-419.Desaintes C., Demeret C., Goyat S. et al. Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis//EMBO J. 1997. V. 16. P. 504-514.Desaintes C., Demeret C., Goyat S. et al. Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis//EMBO J. 1997. V. 16. P. 504-514.Deveraux Q.L., Reed J.C. IAP family proteins: suppressors of apoptosis//Genes & Development. 1999. V. 13. P. 239-252.Deveraux Q.L., Reed J.C. IAP family proteins: suppressors of apoptosis//Genes & Development. 1999. V. 13. P. 239-252.Dimitrov Т., Krajcsi P., Hermiston T.W. et al. Adenovirus E3-10.4K/14.5K protein complex inhibits tumor necrosis factor-induced translocation of cytosolic phospholipase A2 to membranes//J. of Virology. 1997. V. 71. P. 2830-2837.Dimitrov Т., Krajcsi P., Hermiston T.W. et al. Adenovirus E3-10.4K/14.5K protein complex inhibits tumor necrosis factor-induced translocation of cytosolic phospholipase A2 to membranes//J. of Virology. 1997. V. 71. P. 2830-2837.Ekert P.G., Si Ike J., Vaux D.L. Caspase inhibitors//Cell Death and Differentiation. 1999. V. 6. P. 108Ы086.Ekert P.G., Si Ike J., Vaux D.L. Caspase inhibitors//Cell Death and Differentiation. 1999. V. 6. P. 108Ы086.Eliopoulos A.G., Blake S.M., Eloettmann J.E. et al. Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme С terminus via a mechanism involving TRADD and TRAF2//J. of Virology. 1999. V. 73. P. 1023-1035.Eliopoulos A.G., Blake S.M., Eloettmann J.E. et al. Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme С terminus via a mechanism involving TRADD and TRAF2//J. of Virology. 1999. V. 73. P. 1023-1035.Fanidi A., Hancock D.C., Littlewood T.D. Suppression of c-Myc-induced apoptosis by the Epstein-Barr virus gene product BHRF1//J. of Virology. 1998. V. 72. P. 8392-8395.Fanidi A., Hancock D.C., Littlewood T.D. Suppression of c-Myc-induced apoptosis by the Epstein-Barr virus gene product BHRF1//J. of Virology. 1998. V. 72. P. 8392-8395.Gires O., Zimber-Strobl U., Gonnella R. et al. Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule//EMBO J. 1997. V. 16. P. 6131-6140.Gires O., Zimber-Strobl U., Gonnella R. et al. Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule//EMBO J. 1997. V. 16. P. 6131-6140.Granville D.J., Carthy C.M., Yang D. et al. Interaction of viral proteins with host cell death machinery//Cell Death and Differentiation. 1998. V. 5. P. 653-659.Granville D.J., Carthy C.M., Yang D. et al. Interaction of viral proteins with host cell death machinery//Cell Death and Differentiation. 1998. V. 5. P. 653-659.Gross A., McDonnell J.M., Korsmeyer S.J. Bcl-2 family members and the mitochondria in apoptosis//Genes & Development. 1999. V. 13. P. 1899-1911.Gross A., McDonnell J.M., Korsmeyer S.J. Bcl-2 family members and the mitochondria in apoptosis//Genes & Development. 1999. V. 13. P. 1899-1911.Hauashi N., Mita E. Fas system and apoptosis in viral hepatitis//J. Gastroenterol. Hepatol. 1997. V. 12. P. 223-226.Hauashi N., Mita E. Fas system and apoptosis in viral hepatitis//J. Gastroenterol. Hepatol. 1997. V. 12. P. 223-226.Izumi K.M., Kieff E.D. The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate В lymphocyte growth transformation and activate NF-B//Proceedings of the National Academy of Sciences, USA. 1997. V. 94. P. 12592-12597.Izumi K.M., Kieff E.D. The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate В lymphocyte growth transformation and activate NF-B//Proceedings of the National Academy of Sciences, USA. 1997. V. 94. P. 12592-12597.Jerome K.R., Fox R., Chen Z. el al. Herpes simplex virus inhibits apoptosis through the action of two genes, Us5 and Us3//J. of Virology. 1999. V. 73. P. 8950-8957.Jerome K.R., Fox R., Chen Z. el al. Herpes simplex virus inhibits apoptosis through the action of two genes, Us5 and Us3//J. of Virology. 1999. V. 73. P. 8950-8957.Jung Y.K., Yuan J. Suppression of interleukin-1 converting enzyme (ICE)-induced apoptosis by SV40 large T antigen//Oncogene. 1997. V. 14. P. 1207-1214.Jung Y.K., Yuan J. Suppression of interleukin-1 converting enzyme (ICE)-induced apoptosis by SV40 large T antigen//Oncogene. 1997. V. 14. P. 1207-1214.Kamada S., Funahasi Y., Tsujimoto Y. Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases//Cell Death and Differentiation. 1997. V. 4. P. 473-478.Kamada S., Funahasi Y., Tsujimoto Y. Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases//Cell Death and Differentiation. 1997. V. 4. P. 473-478.Khanim F., Dawson C., Meseda C.A. et al. BHRF1, a viral homologue of the Bcl-2 oncogene, is conserved at both the sequence and functional level in different Epstein-Barr virus isolates//J. of General Virology. 1997. V. 78. P. 2987-2999.Khanim F., Dawson C., Meseda C.A. et al. BHRF1, a viral homologue of the Bcl-2 oncogene, is conserved at both the sequence and functional level in different Epstein-Barr virus isolates//J. of General Virology. 1997. V. 78. P. 2987-2999.Kluck R.M., Bossy-Wetzel E., Green D.R. et al. The release of cytochrome с from mitochondria: a primary site for bcl-2 regulation of apoptosis//Science. 1997. V. 275. P. 1132-1136.Kluck R.M., Bossy-Wetzel E., Green D.R. et al. The release of cytochrome с from mitochondria: a primary site for bcl-2 regulation of apoptosis//Science. 1997. V. 275. P. 1132-1136.Kolzau Т., Hansen R.S., Zahra D. et al. Inhibition of SV40 large T antigen induced apoptosis by small T antigen//Oncogene. 1999. V. 18. P. 5598-5603.Kolzau Т., Hansen R.S., Zahra D. et al. Inhibition of SV40 large T antigen induced apoptosis by small T antigen//Oncogene. 1999. V. 18. P. 5598-5603.Lama J., Ware C.F. Human immunodeficiency virus type 1 Nef mediates sustained membrane expression of tumor necrosis factor and the related cytokine LIGHT on activated T cells//J. of Virology. 2000. V. 74. P. 9396-9402.Lama J., Ware C.F. Human immunodeficiency virus type 1 Nef mediates sustained membrane expression of tumor necrosis factor and the related cytokine LIGHT on activated T cells//J. of Virology. 2000. V. 74. P. 9396-9402.Leopardi R., Van Sant C, Roizman B. The herpes simplex virus 1 protein kinase US3 is required for protection from apoptosis induced by the virus//Proceedings of the National Academy of Sciences, USA. 1997. V. 94. P. 7891-7896.Leopardi R., Van Sant C, Roizman B. The herpes simplex virus 1 protein kinase US3 is required for protection from apoptosis induced by the virus//Proceedings of the National Academy of Sciences, USA. 1997. V. 94. P. 7891-7896.Li-Weber M., LaurO., DernK. et al. T-cell activation-induced and HIV tat-enhanced CD95(APO-l/Fas) ligand transcription involves NF-B//Eur. J. of Immunology. 2000. V. 30. P. 661-670.Li-Weber M., LaurO., DernK. et al. T-cell activation-induced and HIV tat-enhanced CD95(APO-l/Fas) ligand transcription involves NF-B//Eur. J. of Immunology. 2000. V. 30. P. 661-670.Marshall W.L., YimC, Gustafson E. et al. Epstein-Barr virus encodes a novel homolog of the bcl-2 oncogene that inhibits apoptosis and associates with Bax and Bak//J. of Virology. 1999. V. 73. P. 5181-5185.Marshall W.L., YimC, Gustafson E. et al. Epstein-Barr virus encodes a novel homolog of the bcl-2 oncogene that inhibits apoptosis and associates with Bax and Bak//J. of Virology. 1999. V. 73. P. 5181-5185.Muzio M., Chinnaiyan A.M., Kischkel F.C. et al. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex//Cell. 1996. V. 85. P. 817-827.Muzio M., Chinnaiyan A.M., Kischkel F.C. et al. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex//Cell. 1996. V. 85. P. 817-827.Niedobitek G., Young L.S., Lau R. et al. Epstein-Barr virus infection in oral hairy leukoplakia: virus replication in the absence of a detectable latent phase//J. of General Virology. 1991. V. 72. P. 3035-3046.Niedobitek G., Young L.S., Lau R. et al. Epstein-Barr virus infection in oral hairy leukoplakia: virus replication in the absence of a detectable latent phase//J. of General Virology. 1991. V. 72. P. 3035-3046.Nogal M.L., Gonzalez de Buitrago G., Rodriguez C. et al. African swine fever virus IAP homologue inhibits caspase activation and promotes cell survival in mammalian cells//J. of Virology. 2001. V. 75. P. 2535-2543.Nogal M.L., Gonzalez de Buitrago G., Rodriguez C. et al. African swine fever virus IAP homologue inhibits caspase activation and promotes cell survival in mammalian cells//J. of Virology. 2001. V. 75. P. 2535-2543.Perez D., White E. TNF-signals apoptosis through a biddependent conformational change in Bax that is inhibited by E1B 19K//Molecular Cell. 2000. V. 6. P. 53-63.Perez D., White E. TNF-signals apoptosis through a biddependent conformational change in Bax that is inhibited by E1B 19K//Molecular Cell. 2000. V. 6. P. 53-63.Pollicino Т., Terradillos O., Lecoeur H. et al. Proapoptotic effect of the hepatitis В virus X gene//Biomed. Phamacoter. 1998. V. 52. № 9. P. 363-368.Pollicino Т., Terradillos O., Lecoeur H. et al. Proapoptotic effect of the hepatitis В virus X gene//Biomed. Phamacoter. 1998. V. 52. № 9. P. 363-368.Rao L., Modha D., White E. The E1B 19K protein associates with lamins in vivo and its proper localization is required for inhibition of apoptosis//Oncogene. 1997. V. 15. P. 1587-1597.Rao L., Modha D., White E. The E1B 19K protein associates with lamins in vivo and its proper localization is required for inhibition of apoptosis//Oncogene. 1997. V. 15. P. 1587-1597.Roulston A., Marcellus R.C., Branton P.E. Viruses and apoptosis//Annual Review of Microbiology. 1999. V. 53. P. 577-628.Roulston A., Marcellus R.C., Branton P.E. Viruses and apoptosis//Annual Review of Microbiology. 1999. V. 53. P. 577-628.Solary E., Dubrez L., Eymin B. The role of apoptosis in the pathogenesis and treatment of diseases//Eur. Respir. J. 1996. V. 9. P. 1293-1305.Solary E., Dubrez L., Eymin B. The role of apoptosis in the pathogenesis and treatment of diseases//Eur. Respir. J. 1996. V. 9. P. 1293-1305.

The authors declare that there are no conflicts of interest present.