ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2015-6-54-60ssmu-377Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL PAPERSРОЛЬ НЕОПТЕРИНА КАК ВОЗМОЖНОГО ДИАГНОСТИЧЕСКОГО МАРКЕРА РАСПРОСТРАНЕННОСТИ НАРУЖНОГО ГЕНИТАЛЬНОГО ЭНДОМЕТРИОЗАTHE ROLE OF NEOPTERIN AS A POSSIBLE DIAGNOSTIC MARKER PREVALENCE EXTERNAL GENITAL ENDOMETRIOSISНовиковаЕ. И.NovikovaYe. I.

аспирант кафедры акушерства и гинекологии № 2, ОГМУ, врач БУЗОО «Клиническая медико-санитарная часть № 9» (г. Омск)  тел.: 8-913-673-6456, 8 (3812) 58-22-28

Omsk State Medical University, Clinical Medical Unit no. 9, Omsk, Russian Federation Ph.: +7-913-673-6456, +7 (3812) 58-22-28

Elena.novikova.omsk@gmail.comНовиковД. Г.NovikovD. G.

канд. мед. наук, зав. Центральной научной исследовательской лабораторией ОГМУ (г. Омск)

Omsk State Medical University, Omsk, Russian Federation.

ИндутныйА. В.IndutnyA. V.

д-р мед. наук, зав. кафедрой лабораторной диагностики ОГМУ (г. Омск)

Omsk State Medical University, Omsk, Russian Federation.

Омский государственный медицинский университет, г. Омск БУЗОО «Клиническая медико-санитарная часть № 9», г. ОмскРоссияOmsk State Medical University, Omsk, Russian Federation Clinical Medical Unit no. 9, Omsk, Russian FederationRussian FederationОмский государственный медицинский университет, г. ОмскРоссияOmsk State Medical University, Omsk, Russian FederationRussian Federation2015281220151465460Copyright © Новикова Е.И., Новиков Д.Г., Индутный А.В., 20152015Новикова Е.И., Новиков Д.Г., Индутный А.В.Novikova Y.I., Novikov D.G., Indutny A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/377Цель исследования

Цель исследования: определить диагностическое значение неоптерина как маркера дисфункции перитонеальных факторов иммунной защиты для оценки распространенности наружного генитального эндометриоза (НГЭ).

Материалы и методы

Материалы и методы. Оценивались клинические данные и концентрация неоптерина в перитонеальной жидкости (ПЖ) и венозной крови у 16 пациенток с НГЭ и 10 пациенток с доброкачественными новообразованиями яичников.

Результаты

Результаты. Не было получено статистически значимой взаимосвязи между концентрацией исследуемого маркера в венозной крови и клиническими данными. Выявлена корреляция между концентрацией неоптерина в ПЖ пациенток с НГЭ и болевым синдромом по шкале B’n’B (r = 0,545, р = 0,044) и шкале NRC(r = 0,362 p = 0,203). Обнаружена взаимосвязь между концентрацией неоптерина в ПЖ пациенток с эндометриозом и распространенностью эндометриоза по шкале rAFS (r = 0,598, p = 0,051), распространенностью спаечного процесса при НГЭ по шкале rAFS (r = 0,487, p = 0,128).

Заключение

Заключение. Таким образом, представляется возможным использовать определение концентрации неоптерина в ПЖ пациенток с НГЭ для комплексной оценки тяжести заболевания и прогнозирования распространения и рецидивирования процесса.

Objective

Objective. Todetermine the diagnostic value of neopterin as a marker of dysfunction of peritoneal immune factors for estimating the severity of external genital endometriosis (EGE).

Material and methods

Material and methods. The concentration of neopterin in the peritoneal fluid (PF) and venous blood of 16 patients with EGE and 10 patients with benign ovarian cysts were evaluated.

Results

Results. There wasn’t significant relationship between the concentration of the neopterin in the venous blood and clinical data. There weren't significant relationship between the concentration of the neopterin in the venous blood and clinical data. There were the significant correlation between the concentration of neopterin in the PF of patients with EGE and pain by the B'n'B scale (r = 0.545, p = 0.044) and pain by NRC scale of (r = 0.362 p = 0.203). There were correlation between the concentration of neopterin in the PF of patients with EGE and the severity of endometriosis by rAFS scale (r = 0.598, p = 0.051), and between the neopterin concentration in PF and adhesions (r = 0.487, p = 0.128).

Conclusion

Conclusion. Thus, it is possible to use the the neopterin concentrations in the PF of patients with EGE as a marker of disease severity and as a predictor of recurrence endometriosis.

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The authors declare that there are no conflicts of interest present.