ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2002-1-57-62ssmu-3855Research ArticleФУНДАМЕНТАЛЬНЫЕ КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯФУНДАМЕНТАЛЬНЫЕ КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯКлеточный иммунитет у беременных с аутоиммунным тиреоидитом и гестозомCell immunity at pregnant women with autoimmune thyroiditis and gestosisМахмутходжаевА. Ш.MakhmuthodzhayevA. Sh.

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ОгородоваЛ. М.OgorodovaL. M.

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ЕвтушенкоИ. Д.EvtushenkoI. D.

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ХолоповА. В.HolopovA. V.

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ТимошинаЕ. Л.TimoshinaE. L.

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МахмутходжаеваЕ. В.MakhmuthodzhayevaE. V.

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Сибирский государственный медицинский университет; Роддом 4Russian Federation200230032002115762Copyright © Махмутходжаев А.Ш., Огородова Л.М., Евтушенко И.Д., Холопов А.В., Тимошина Е.Л., Махмутходжаева Е.В., 20022002Махмутходжаев А.Ш., Огородова Л.М., Евтушенко И.Д., Холопов А.В., Тимошина Е.Л., Махмутходжаева Е.В.Makhmuthodzhayev A.S., Ogorodova L.M., Evtushenko I.D., Holopov A.V., Timoshina E.L., Makhmuthodzhayeva E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/3855

Проведено проспективное исследование 60 беременных с хроническим аутоиммунным тиреоидитом (АИТ) и 30 сопоставимых по возрасту и паритету пациенток без патологии щитовидной железы. При сроке беременности 12 и 32 нед проводилась оценка процентного содержания в периферической крови субпопуляций лимфоцитов (CD3, CD4, CD8, CD16, HLA-DR антигена главного комплекса гистосовместимости класса 2), уровней ИЛ-2, ИФН-гамма, тиреопероксидазных антител, тиреотропного гормона (ТТГ) и тироксина. У 25 беременных с АИТ (41,7%) развился гестоз (при 16,7% в контроле). Обусловленные беременностью изменения клеточного иммунитета при сроке гестации 12 нед включали снижение уровня CD16+ NK-клеток и всех субпопуляций Т-лимфоцитов. Развитие гестоза у пациенток с АИТ сопровождалось увеличением процентного содержания HLA-DR+ Т-лимфоцитов. Высокий уровень тиреопероксидазных аутоантител и активных Т-лимфоцитов у беременных с АИТ может рассматриваться в качестве прогностического фактора развития у этих пациенток гестоза.

In a prospective study the group of 60 women with AIT and thyroidological uneventful control women, matched for age and parity (n = 30) were tested at 12 and 32 weeks gestation for percentages of peripheral blood lymphocyte subsets (CD3, CD4, CD8, CD16, HLA-DR major histocompatibility complex (MHC)-class II), IL-2, IFN-gamma, TPO-Abs, TSH and thyroxin. Twenty five pregnant women with AIT (41,7%) developed preeclampsia (against 16,7% in control). Pregnancyrelated CMI alterations consisted of low percentages of CD16+ NK cells and all subpopulations of T-cells at 12 weeks gestation. The development of preeclampsia in women with AIT was accompanied with increasing percentage of HLADR+ T- lymphocytes. The high levels of TPO-Abs and activated T-lymphocytes in pregnant women with autoimmune thyroiditis has been suggested as a predictor for later preeclampsia development.

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The authors declare that there are no conflicts of interest present.