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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ssmu</journal-id><journal-title-group><journal-title xml:lang="ru">Бюллетень сибирской медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of Siberian Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-0363</issn><issn pub-type="epub">1819-3684</issn><publisher><publisher-name>Siberian State Medical University, the Ministry of Healthcare of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20538/1682-0363-2002-2-71-77</article-id><article-id custom-type="elpub" pub-id-type="custom">ssmu-3967</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СТРАНИЧКА ПРАКТИЧЕСКОГО ВРАЧА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>THE PAGE OF PRACTICAL DOCTOR</subject></subj-group></article-categories><title-group><article-title>Рак печени, желчных путей и поджелудочной железы при хроническом описторхозе</article-title><trans-title-group xml:lang="en"><trans-title>Cancer of liver, biliary tracts and pancreas at chronic opisthorchosis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бражникова</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Brazhnikova</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Томск</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Толкаева</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tolkaeva</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Томск</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Сибирский государственный медицинский университет;&#13;
Городская клиническая больница ‹ 3</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2002</year></pub-date><pub-date pub-type="epub"><day>30</day><month>06</month><year>2002</year></pub-date><volume>1</volume><issue>2</issue><fpage>71</fpage><lpage>77</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бражникова Н.А., Толкаева М.В., 2002</copyright-statement><copyright-year>2002</copyright-year><copyright-holder xml:lang="ru">Бражникова Н.А., Толкаева М.В.</copyright-holder><copyright-holder xml:lang="en">Brazhnikova N.A., Tolkaeva M.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://bulletin.ssmu.ru/jour/article/view/3967">https://bulletin.ssmu.ru/jour/article/view/3967</self-uri><abstract><p>Длительная описторхозная инвазия может сопровождаться развитием осложненных форм заболевания, требующих оперативных способов лечения. Среди 1170 больных описторхозом, оперированных в Томском гепатологическом центре, в 13% случаев выявлен рак печени, желчевыводящих путей и поджелудочной железы. Клинические признаки рака длительное время маскируются проявлениями описторхоза, что приводит к III—IV стадии процесса. Значимыми в диагностике являются ультразвуковое исследование и эндоскопические методы: ЭГДС, РХПГ, лапароскопия. Операции носят преимущественно паллиативный (57,4%) или эксплоративный (13%) характер. Лишь в 10,6% случаев удалось выполнить радикальные операции, а в 19% была нецелесообразной даже лапаротомия. Рекомендуется диспансеризация больных хроническим описторхозом с обязательным проведением УЗИ и ЭГДС не реже одного раза в год, своевременная адекватная дегельминтизация.</p></abstract><trans-abstract xml:lang="en"><p>The long-term opisthorchiasis invasion leads to serious complications followed by surgery. Between 1170 patients with O.felineus, undergone an operation at the Tomsk hepatologic center, carcinoma of the liver, bile ducts and pancreas was revealed in 13% of cases. Clinical manifestations of carcinoma are masked by signs of opisthorchiasis for a long time, that leads to the process of a disease of stage III—IV. Ultrasonography and endoscopic methods of examination such fibrogastroscopy, pancreatography, laparoscopy seem to be of great importance in diagnosis. All operations are, mainly, of palliative (57,4%) or explorative (13%) character. Radical operations were made in 10,6% of cases only, laparotomy was of no use in 19% of patients. It is recommended to make a prophylactic medical examination of patients with opisthorchiasis including obligatory ultrasound and endoscopic methods once a year at least, an adequate timely dehelminthization.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>осложнения описторхоза</kwd><kwd>холангиокарцинома</kwd><kwd>рак поджелудочной железы</kwd><kwd>ультразвуковое исследование</kwd></kwd-group><kwd-group xml:lang="en"><kwd>complications of opisthorchiasis</kwd><kwd>cholangiocarcinoma</kwd><kwd>cancer of pancreas</kwd><kwd>ultrasonography</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Бражникова Н.А. Хирургические осложнения хронического описторхоза//Анналы хирург. гепатологии. 1997. Т. 2. С. 88-93.</mixed-citation><mixed-citation xml:lang="en">Бражникова Н.А. Хирургические осложнения хронического описторхоза//Анналы хирург. гепатологии. 1997. Т. 2. С. 88-93.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Бычков В.Г. Описторхоз и рак печени у населения гиперэндемичного очага. Новосибирск: Наука, 1992. 175 с.</mixed-citation><mixed-citation xml:lang="en">Бычков В.Г. Описторхоз и рак печени у населения гиперэндемичного очага. Новосибирск: Наука, 1992. 175 с.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Глумов В.Я., Котриков В.В., Третьякова Н.А. Патогенез и морфология первичного рака печени, развившегося на фоне описторхоза//Вопросы онкологии. 1974. № 9. С. 46-49.</mixed-citation><mixed-citation xml:lang="en">Глумов В.Я., Котриков В.В., Третьякова Н.А. Патогенез и морфология первичного рака печени, развившегося на фоне описторхоза//Вопросы онкологии. 1974. № 9. С. 46-49.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Зубов Н.А., Чернова А.С. Морфология холангиоцеллюлярного рака, развившегося на фоне описторхоза//Описторхоз человека: Матер. межобл. науч.-практ. конф. Томск, 1979. С. 75-77.</mixed-citation><mixed-citation xml:lang="en">Зубов Н.А., Чернова А.С. Морфология холангиоцеллюлярного рака, развившегося на фоне описторхоза//Описторхоз человека: Матер. межобл. науч.-практ. конф. Томск, 1979. С. 75-77.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Толкаева М.В. Ультразвуковая диагностика хирургических осложнений описторхоза: Автореф. дис.... канд. мед. наук. Томск, 1999. 23 с.</mixed-citation><mixed-citation xml:lang="en">Толкаева М.В. Ультразвуковая диагностика хирургических осложнений описторхоза: Автореф. дис.... канд. мед. наук. Томск, 1999. 23 с.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Шайн А.А. Описторхоз как предрак гепатопанкреатодуоденальной зоны//Матер, межобл. научно-практ. конф. по пробл. «Описторхоз человека». Томск, 1979. С. 202-203.</mixed-citation><mixed-citation xml:lang="en">Шайн А.А. Описторхоз как предрак гепатопанкреатодуоденальной зоны//Матер, межобл. научно-практ. конф. по пробл. «Описторхоз человека». Томск, 1979. С. 202-203.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Bhudhisawasdi V. Place of surgery in opisthorchiasis associated cholangiocarcinoma.//Southeast. Asian. J. Trop. Med. Public. Health. 1997. V. 28. № 1. P. 85-90.</mixed-citation><mixed-citation xml:lang="en">Bhudhisawasdi V. Place of surgery in opisthorchiasis associated cholangiocarcinoma.//Southeast. Asian. J. Trop. Med. Public. Health. 1997. V. 28. № 1. P. 85-90.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Chiu A., Neff M., Garcia G. Late complications of infection with Opisthorchis viverrini//West J. Med. 1996. V. 164. № 2. P. 174-176.</mixed-citation><mixed-citation xml:lang="en">Chiu A., Neff M., Garcia G. Late complications of infection with Opisthorchis viverrini//West J. Med. 1996. V. 164. № 2. P. 174-176.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Cholangiocarcinoma: a spectrum of intrahepatic, perihilar and distal tumors/A. Nakeeb, A. Henry, A. Teylor et al.//Annals of Surgery. 1996. V. 224. № 4. P. 463-475.</mixed-citation><mixed-citation xml:lang="en">Cholangiocarcinoma: a spectrum of intrahepatic, perihilar and distal tumors/A. Nakeeb, A. Henry, A. Teylor et al.//Annals of Surgery. 1996. V. 224. № 4. P. 463-475.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Cross-sectional patterns of hepatobiliary abnormalities and possible precursor conditions of cholangiocarcinoma associated with Opisthorchis viverrini infection in humans/D.B. Elkins, E. Mairiang, P. Sithithaworn et al.//Am J. Trop. Med. Hug. 1996. V. 55. № 3. P. 295-301.</mixed-citation><mixed-citation xml:lang="en">Cross-sectional patterns of hepatobiliary abnormalities and possible precursor conditions of cholangiocarcinoma associated with Opisthorchis viverrini infection in humans/D.B. Elkins, E. Mairiang, P. Sithithaworn et al.//Am J. Trop. Med. Hug. 1996. V. 55. № 3. P. 295-301.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Enhancement of DHPN induced hepatocellular, cholangiocellular and pancreatic carcinogenesis by Opisthorchis viverrini infestation in Syrian golden hamsters./W.Thamavit, M.A. Moore, Y.Hiasa, Ito N.//Carcinogenesis. 1988. V. 9. № 6. P. 1095-1098.</mixed-citation><mixed-citation xml:lang="en">Enhancement of DHPN induced hepatocellular, cholangiocellular and pancreatic carcinogenesis by Opisthorchis viverrini infestation in Syrian golden hamsters./W.Thamavit, M.A. Moore, Y.Hiasa, Ito N.//Carcinogenesis. 1988. V. 9. № 6. P. 1095-1098.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Precancerous lesions of the biliary tree/F.Callea, C.Sergi, G.Fabbretti et al.//J. Surg. Oncol. Suppl. 1993. V. 3. P. 131-133.</mixed-citation><mixed-citation xml:lang="en">Precancerous lesions of the biliary tree/F.Callea, C.Sergi, G.Fabbretti et al.//J. Surg. Oncol. Suppl. 1993. V. 3. P. 131-133.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Schwartz D.A. Revico: Helmints in the induction of cancers. Opisthorchis felineus, cholangiocarcinoma//Tropical and Geograph. Med. 1990. V. 32. P. 95-100.</mixed-citation><mixed-citation xml:lang="en">Schwartz D.A. Revico: Helmints in the induction of cancers. Opisthorchis felineus, cholangiocarcinoma//Tropical and Geograph. Med. 1990. V. 32. P. 95-100.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Sinawat P., Hemsrichart V. A histopathologic study of 61 cases of peripheral intrahepatic cholangiocarcinoma//J. Med. Assoc. Thai. 1991. V. 74. № 10. P. 448-453.</mixed-citation><mixed-citation xml:lang="en">Sinawat P., Hemsrichart V. A histopathologic study of 61 cases of peripheral intrahepatic cholangiocarcinoma//J. Med. Assoc. Thai. 1991. V. 74. № 10. P. 448-453.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Sriamporn S. Epidemiologic study of liver cancer using a population-based cancer registry as a guide in Khon Kaen, Thailand//Health Rep. 1993. V. 5. № 1. P. 51-58.</mixed-citation><mixed-citation xml:lang="en">Sriamporn S. Epidemiologic study of liver cancer using a population-based cancer registry as a guide in Khon Kaen, Thailand//Health Rep. 1993. V. 5. № 1. P. 51-58.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Watanapa P. Cholangiocarcinoma in patients with Opisthorchiasis//Br. J. Surgery. 1996. V. 38. № 8. P. 1062-1064.</mixed-citation><mixed-citation xml:lang="en">Watanapa P. Cholangiocarcinoma in patients with Opisthorchiasis//Br. J. Surgery. 1996. V. 38. № 8. P. 1062-1064.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
