ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2002-4-65-74ssmu-4012Research ArticleСТРАНИЧКА ПРАКТИЧЕСКОГО ВРАЧАTHE PAGE OF PRACTICAL DOCTORГиперреактивность дыхательных путей при бронхиальной астме: основы патогенезаAirway hyperresponsiveness in bronchial asthma: pathogenesis basicsДеевИ. А.DeyevI. A.

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ПетроваИ. В.PetrovaI. V.

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КармалитаЕ. Г.KarmalitaE. G.

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ПетровскийФ. И.PetrovskyF. I.

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ОгородоваЛ. М.OgorodovaL. M.

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Сибирский государственный медицинский университетRussian Federation200230122002146574Copyright © Деев И.А., Петрова И.В., Кармалита Е.Г., Петровский Ф.И., Огородова Л.М., 20022002Деев И.А., Петрова И.В., Кармалита Е.Г., Петровский Ф.И., Огородова Л.М.Deyev I.A., Petrova I.V., Karmalita E.G., Petrovsky F.I., Ogorodova L.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/4012

Известно, что бронхиальная астма характеризуется наличием двух основных патогенетических составляющих — это персистирующее хроническое воспаление в бронхах и бронхиальная гиперреактивность к различным неспецифическим триггерам. Формирование бронхиальной гиперреактивности при бронхиальной астме взаимосвязано с персистирующим воспалением стенки бронхиального дерева, высоким уровенем IgE в сыворотке крови, изменением функции гладкой мускулатуры бронхов, наличием структурных изменений стенки бронхиального дерева, а также нарушением нейрорегуляции бронхомоторного тонуса.

Bronchial asthma has three main components: persistent bronchial inflammation, reversible bronchial obstruction and bronchial hyperresponsiveness to nonspecific triggers. Airway hyperresponsiveness is a complex phenomenon that develops upon the influence of chronic inflammation, high total IgE, changes in bronchial smooth muscle cells functioning, structural changes in bronchial wall and disturbances in neural regulation of bronchial tone.

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The authors declare that there are no conflicts of interest present.