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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ssmu</journal-id><journal-title-group><journal-title xml:lang="ru">Бюллетень сибирской медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of Siberian Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-0363</issn><issn pub-type="epub">1819-3684</issn><publisher><publisher-name>Siberian State Medical University, the Ministry of Healthcare of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20538/1682-0363-2020-4-215-225</article-id><article-id custom-type="elpub" pub-id-type="custom">ssmu-4171</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ И ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW AND LECTURES</subject></subj-group></article-categories><title-group><article-title>Экстрацеллюлярный матрикс как информационная клеточная микросреда</article-title><trans-title-group xml:lang="en"><trans-title>Еxtracellular matrix as a cellular information microenvironment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1145-3710</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Наумова</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Naumova</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, профессор, кафедра патофизиологии и общей патологии, МИ</p><p>Россия, 628412, Ханты-Мансийский автономный округ – Югра, г. Сургут, ул. Ленина, 1</p></bio><bio xml:lang="en"><p>1, Lenina Str., Surgut, Khanty-Mansiysk Autonomous Area – Yugra, 628412, Russian Federation</p></bio><email xlink:type="simple">naumovala@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8362-0608</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Стародумова</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Starodumova</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант, кафедра патофизиологии и общей патологии, МИ</p><p>Россия, 628412, Ханты-Мансийский автономный округ – Югра, г. Сургут, ул. Ленина, 1</p></bio><bio xml:lang="en"><p>1, Lenina Str., Surgut, Khanty-Mansiysk Autonomous Area – Yugra, 628412, Russian Federation</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Сургутский государственный университет (СурГУ)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Surgut State University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>07</day><month>01</month><year>2021</year></pub-date><volume>19</volume><issue>4</issue><fpage>215</fpage><lpage>225</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Наумова Л.А., Стародумова В.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Наумова Л.А., Стародумова В.А.</copyright-holder><copyright-holder xml:lang="en">Naumova L.A., Starodumova V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://bulletin.ssmu.ru/jour/article/view/4171">https://bulletin.ssmu.ru/jour/article/view/4171</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>экстрацеллюлярный матрикс</kwd><kwd>эпителио-стромальные отношения и канцерогенез</kwd><kwd>фибробласт</kwd><kwd>опухолевое поле</kwd><kwd>преметастатические ниши</kwd></kwd-group><kwd-group xml:lang="en"><kwd>extracellular matrix</kwd><kwd>epithelial-stromal relations and carcinogenesis</kwd><kwd>fibroblast</kwd><kwd>field cancerization</kwd><kwd>premetastatic niches</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Шехтер А.Б., Серов В.В. 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