ssmuБюллетень сибирской медициныBulletin of Siberian Medicine1682-03631819-3684Siberian State Medical University, the Ministry of Healthcare of the Russian Federation10.20538/1682-0363-2021-1-119-128ssmu-4286Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEW AND LECTURESЭкспрессия иммуноглобулинов в эпителиальных опухолях человека и их потенциальная роль в канцерогенезеExpression of immunoglobulins in human epithelial tumors and their potential role in carcinogenesishttps://orcid.org/0000-0002-1014-752XАртемьеваК. А.ArtemyevaK. A.

  канд. мед. наук, науч. сотрудник, лаборатория патологии репродукции

Россия, 117418, г. Москва, ул. Цурюпы, 3 

 3, Tsuryupy Str., Moscow, 117418, Russian Federation 

artemjeva_ksenia@mail.ruБогдановаИ. М.BogdanovaI. M.

 канд. биол. наук, вед. науч. сотрудник, лаборатория патологии репродукции

 Россия, 117418, г. Москва, ул. Цурюпы, 3 

 3, Tsuryupy Str., Moscow, 117418, Russian Federation 

https://orcid.org/0000-0002-9751-2066БолтовскаяМ. Н.BoltovskayaM. N.

 д-р биол. наук, зав. лабораторией патологии репродукции

 Россия, 117418, г. Москва, ул. Цурюпы, 3 

 3, Tsuryupy Str., Moscow, 117418, Russian Federation 

https://orcid.org/0000-0003-3628-2436КалюжинО. В.KalyuzhinO. V.

  д-р мед. наук, профессор, кафедра клинической иммунологии и аллергологии

Россия, 119991, г. Москва, ул. Большая Пироговская, 2, стр. 4 

Bld. 4, 2, Bolshaya Pirogovskaya Str., Moscow, 119991, Russian Federation 

Научно-исследовательский институт (НИИ) морфологии человекаРоссияResearch Institute of Human MorphologyRussian FederationПервый Московский государственный медицинский университет им. И.М. Сеченова (Первый МГМУ им. И.М. Сеченова)РоссияI.M. Sechenov First Moscow State Medical University (I.M. Sechenov First MSMU)Russian Federation202109042021201119128Copyright © Артемьева К.А., Богданова И.М., Болтовская М.Н., Калюжин О.В., 20212021Артемьева К.А., Богданова И.М., Болтовская М.Н., Калюжин О.В.Artemyeva K.A., Bogdanova I.M., Boltovskaya M.N., Kalyuzhin O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://bulletin.ssmu.ru/jour/article/view/4286

 Традиционное представление о продукции  иммуноглобулинов (Ig) только В-лимфоцитами и плазматическими клетками в последнее время подвергается  ревизии. Клетки нелимфоидных опухолей также могут синтезировать и секретировать Ig  неидентифицированной специфичности. Экспрессия генов  Ig выявлена в клетках злокачественных новообразований эпителиального происхождения, таких как карцинома молочной железы, колоректальный рак, рак предстательной  железы, а также в эпителиальных опухолевых линиях. В линиях раковых клеток и резецированных тканях карцином были обнаружены мРНК константной области тяжелых (Н) цепей IgG1, стерильный транскрипт Iɣ-Cɣ, H- и легкие (L)  цепи IgG, V(D)J-рекомбинация генных сегментов H- и L- цепей, а также ферменты RAG1 (recombination-activating  gene 1) и RAG2, необходимые для V(D)J-рекомбинации. Продуцируемый раковыми клетками IgG может быть вовлечен в инвазию и метастазирование этих клеток через взаимодействие с Е-кадгерином, а также с белком-1,  ассоциированным с метастазированием (MTA1). Опухолевые  IgG играют важную роль в злокачественном прогрессировании, активируя тромбоциты путем  взаимодействия с их рецепторами FcγRIIa и индуцируя выработку низких уровней активных форм кислорода.  Уровень IgG в злокачественных новообразованиях положительно коррелирует с маркерами пролиферации,  стадией развития, ростом и выживаемостью опухоли. Эти данные модернизируют представления о механизмах  канцерогенеза и создают фундамент для поиска новых критериев диагностики и прогноза течения злокачественных  новообразований, а также методов их таргетной терапии. Необходимы дальнейшие углубленные  исследования феномена продукции Ig опухолевыми клетками для более эффективного практического  использования накопленных в этой области знаний. 

 The traditional view of immunoglobulin (Ig) production only by B-lymphocytes and plasma cells has been revisited. Non-lymphoid tumor cells can also synthesize and secrete Ig with unidentified specificity. Expression of Ig genes was detected in the cells of malignant neoplasms of epithelial origin, such as breast carcinoma, colorectal cancer, prostate cancer, as well as in epithelial tumor cell lines. mRNA of the IgG1 heavy (H) chain constant region, sterile Iɣ-Cɣ transcript, H and light (L) chains of IgG, V(D)J recombination of H and L chain gene segments, as well as RAG1 (recombination-activating gene 1) and RAG2 enzymes, which are required for V(D)J recombination, were found in cancer cell lines and resected carcinoma tissues. IgG produced by cancer cells can be involved in the invasion and metastasis of these cells through interaction with E-cadherin, as well as with the metastasis-associated protein MTA1. Tumor-derived IgG plays an important role in malignant progression via activation of platelets by interacting with their FcγRIIa receptors and inducing the production of low levels of reactive oxygen species. The level of IgG in malignant neoplasms is positively correlated with proliferation markers, stage of progression, growth and survival of the tumor. These data modernize the current views on the mechanisms of carcinogenesis and create the basis for the search for new diagnostic and prognostic markers in malignant neoplasms, as well as methods of their target therapy. Further in-depth studies of the  phenomenon of Ig production by tumor cells will contribute to more effective practical application of the accumulated knowledge in this field. 

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The authors declare that there are no conflicts of interest present.